2,2-dimethyl-6-hydroxy-1,3-benzodioxane | 93134-95-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2,2-dimethyl-6-hydroxy-1,3-benzodioxane
• 英文别名: 4H-1,3-Benzodioxin-6-ol, 2,2-dimethyl-；2,2-dimethyl-4H-1,3-benzodioxin-6-ol
• CAS: 93134-95-3
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: BFUBIUBVFUKOJL-UHFFFAOYSA-N

物化性质

• 熔点：
  78-79 °C
• 沸点：
  322.9±42.0 °C(Predicted)
• 密度：
  1.161±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-6-hydroxy-1,3-benzodioxane 在 potassium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 13.0h， 生成 ethyl <2,3-dichloro-4-<<3-(hydroxymethyl)-4-(benzyloxy)phenoxy>methyl>phenoxy>acetate
  参考文献：
  名称：

  [(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 3. Variation in the bridge between the aromatic rings to complete mapping of the receptor

  摘要：

  Continued structural evaluation of the [(aminomethyl)aryloxy]acetic ester diuretics has produced a series of compounds in which the functional group that bridges the two aromatic rings has been varied. Diuretic screening of these analogues in rats indicates that the keto group can be effectively replaced with an ether or thio ether function with a slight increase in potency, whereas the methylene and sulfoxide linking groups lead to diminished saluretic potency. Replacement with either -SO2-, -COCO-, -CH2O-, -CONH- or direct bond results in a loss of activity. Although the series was designed according to QSAR criteria, the traditional linear free-energy properties of these compounds do not correlate with diuretic potency. However, conformational analysis of the series by potential energy calculations indicates that all active compounds have an accessible conformation that matches the bridge atom-carboxylate distance of the very potent dihydrobenzofuran analogue 56. Conformational calculations of several compounds in which the aminomethyl group was varied suggests that the active conformation is probably a low-energy conformation. Consideration of rotation about the bridge could not distinguish between two possible orientations of the aminomethyl ring in the active conformation. However, there is a quantitative negative linear correlation between diuretic potency and the protrusion into space of the group that bridges the two aromatic rings.

  DOI：

  10.1021/jm00379a016
• 作为产物：
  描述：

  C₁₆H₂₆O₃Si 在 potassium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以75%的产率得到2,2-dimethyl-6-hydroxy-1,3-benzodioxane
  参考文献：
  名称：

  Thienopyrimidines as β3-adrenoceptor agonists: Hit-to-lead optimization

  摘要：

  Resulting from a vHTS based on a pharmacophore alignment on known beta 3-adrenoceptor ligands, an aryloxypropanolamine scaffold comprising a thienopyrimidine moiety was further optimized as a human beta 3-AR agonist, yielding a lead compound with an excellent cellular activity of EC(50) = 20 pM, selectivity over h beta 1- and h beta 2- adrenoceptors and a promising safety profile. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.039

文献信息

• PLATTNER, J. J.;MARTIN, Y. C.;SMITAL, J. R.;LEE, C. -M.;FUNG, A. K. L.;HO+, J. MED. CHEM., 1985, 28, N 1, 79-93
  作者：PLATTNER, J. J.、MARTIN, Y. C.、SMITAL, J. R.、LEE, C. -M.、FUNG, A. K. L.、HO+

  DOI：——

  日期：——
• Thienopyrimidines as β3-adrenoceptor agonists: Hit-to-lead optimization
  作者：Stefan Tasler、Roland Baumgartner、Astrid Ammendola、Josef Schachtner、Tanja Wieber、Marcus Blisse、Sandra Rath、Mirko Zaja、Philipp Klahn、Udo Quotschalla、Peter Ney

  DOI：10.1016/j.bmcl.2010.08.039

  日期：2010.10

  Resulting from a vHTS based on a pharmacophore alignment on known beta 3-adrenoceptor ligands, an aryloxypropanolamine scaffold comprising a thienopyrimidine moiety was further optimized as a human beta 3-AR agonist, yielding a lead compound with an excellent cellular activity of EC(50) = 20 pM, selectivity over h beta 1- and h beta 2- adrenoceptors and a promising safety profile. (C) 2010 Elsevier Ltd. All rights reserved.
• [(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 3. Variation in the bridge between the aromatic rings to complete mapping of the receptor
  作者：Jacob J. Plattner、Yvonne C. Martin、Jill R. Smital、Cheuk Man Lee、Anthony K. L. Fung、Bruce W. Horrom、Steven R. Crowley、Andre G. Pernet、Paul R. Bunnell、Ki H. Kim

  DOI：10.1021/jm00379a016

  日期：1985.1

  Continued structural evaluation of the [(aminomethyl)aryloxy]acetic ester diuretics has produced a series of compounds in which the functional group that bridges the two aromatic rings has been varied. Diuretic screening of these analogues in rats indicates that the keto group can be effectively replaced with an ether or thio ether function with a slight increase in potency, whereas the methylene and sulfoxide linking groups lead to diminished saluretic potency. Replacement with either -SO2-, -COCO-, -CH2O-, -CONH- or direct bond results in a loss of activity. Although the series was designed according to QSAR criteria, the traditional linear free-energy properties of these compounds do not correlate with diuretic potency. However, conformational analysis of the series by potential energy calculations indicates that all active compounds have an accessible conformation that matches the bridge atom-carboxylate distance of the very potent dihydrobenzofuran analogue 56. Conformational calculations of several compounds in which the aminomethyl group was varied suggests that the active conformation is probably a low-energy conformation. Consideration of rotation about the bridge could not distinguish between two possible orientations of the aminomethyl ring in the active conformation. However, there is a quantitative negative linear correlation between diuretic potency and the protrusion into space of the group that bridges the two aromatic rings.