3-[(3-chloro-4-cyanophenyl) thio]propionic acid | 1310133-34-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(3-chloro-4-cyanophenyl) thio]propionic acid
• 英文别名: 3-(3-Chloro-4-cyanophenyl)sulfanylpropanoic acid
• CAS: 1310133-34-6
• 化学式: C₁₀H₈ClNO₂S
• 分子量: 241.698
• InChiKey: RCLGFXZJPZQNSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氯-4-氟苯腈 、 N,N-二甲基甲酰胺 、 3-巯基丙酸 在 potassium carbonate 作用下， 生成 3-[(3-chloro-4-cyanophenyl) thio]propionic acid
  参考文献：
  名称：

  Triazene-based compound comprising functionalized alkylthio groups, and photopolymerization initiator

  摘要：

  本预设发明涉及一种光敏组合物，并提供了一种三嗪基化合物，其中包括新的功能化烷基硫基团，其在室温下的长期储存特性以及作为光聚合引发剂的光化学活性均优越。

  公开号：

  US06797739B1

文献信息

• Display Panel Including Patterned Spacer
  申请人：Kim Sung Hyun

  公开号：US20080213514A1

  公开（公告）日：2008-09-04

  Disclosed is a display panel including a lower substrate, upper substrate, and a patterned spacer that causes the lower substrate and upper substrate to be spaced apart from each other by a predetermined distance, wherein the patterned spacer is obtained from a photo-sensitive resin composition comprising: (a) a triazine-based photopolymerization initiator represented by the following formula 1; (b) an alkali-soluble photo polymerizable reactive resin binder; and (c) a polymerizable compound: (wherein each of R1-R5 has the same meaning as defined herein). A photosensitive resin composition for use in a patterned spacer is also disclosed, the composition comprising: (a) a triazine-based photopolymerization initiator represented by the following formula 1; (b) an alkali-soluble photopolymerizable reactive resin binder; (c) a polymerizable compound; and (d) a solvent. The photosensitive resin composition shows high sensitivity and excellent properties related with development, and provides a patterned spacer having excellent strength, sensitivity, residue characteristics, film uniformity, residual film ratio, etc.

  本发明公开了一种显示面板，包括下部基板、上部基板和图案间隔器，该图案间隔器使得下部基板和上部基板相互间隔一个预定距离，其中，所述图案间隔器是由以下组分组成的光敏树脂组合物制得：(a)一种由以下公式1表示的三嗪基光聚合引发剂；(b)一种碱溶性光聚合反应树脂粘合剂；以及(c)一种聚合物化合物：(其中，R1-R5中的每一个具有如下所定义的相同含义)。本发明还公开了一种用于图案间隔器的光敏树脂组合物，该组合物包括：(a)一种由以下公式1表示的三嗪基光聚合引发剂；(b)一种碱溶性光聚合反应树脂粘合剂；(c)一种聚合物化合物；以及(d)一种溶剂。所述光敏树脂组合物具有高灵敏度和与显影相关的优异性能，并提供具有优异强度、灵敏度、残留特性、膜均匀性、残留膜比率等特性的图案间隔器。
• Lipid assemblies and uses thereof and some pH and electrostatic modulating lipids to be used in said assemblies
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：US10722599B2

  公开（公告）日：2020-07-28

  Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.

  提供了改性脂质化合物及其在脂质组合物形成中的用途。还提供了脂质组合物，包括(a)与(i)一个或多个酰基链；(ii)一个或多个弱碱分子；(iii)一个或多个弱酸分子共价结合的两性脂质；脂质组合物还包括(b)一个或多个附加脂质，其中至少一个是齐聚物脂质。在某些实施方案中，两性脂质是一种化合物，包括：(a) 三官能团分子；(b) 与所述三官能团分子的两个官能团分子相关联的两条非磷酸脂质链；(c) 与所述三官能团分子的第三个官能团分子相关联的间隔分子；以及(d) 多烷基胺，可选地包括具有一至数个羧酸残基的短肽。此外，还提供了脂质组合物的用途，特别是用于转染或癌症治疗。
• TRIAZINE-BASED COMPOUND COMPRISING FUNCTIONALIZED ALKYLTHIO GROUPS, AND PHOTOPOLYMERIZATION INITIATOR
  申请人：LG Chemical Co. Ltd

  公开号：EP1289967A1

  公开（公告）日：2003-03-12
• Method for preparing liposome formulations with a predefined release profile
  申请人：Barenholz Yechezkel

  公开号：US20080213353A1

  公开（公告）日：2008-09-04

  The present invention provides a novel tool for designing a release profile of an active agent from a liposome in to which it is loaded. According to the invention, a method is provided for preparing a liposomal formulation for delivery of an active agent to a target, the release of said active agent from the liposome being designed to have a release profile in which the release is sustained for a time period to achieve an optimal effect of the active agent at said target, the method comprising preparing a liposomal formulation, wherein the liposome is loaded with said active agent and with a selected counter ion, the counter ion and the active agent interacting together to aggregate and/or to form a precipitate within the liposome, the counter ion being selected such that the release of the active agent from the liposome has said release profile.
• LIPID ASSEMBLIES AND USES THEREOF AND SOME pH AND ELECTROSTATIC MODULATING LIPIDS TO BE USED IN SAID ASSEMBLIES
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：US20180043036A1

  公开（公告）日：2018-02-15

  Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.