4-(methallyloxy)benzophenone | 112005-08-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(methallyloxy)benzophenone
• 英文别名: 4-methallyloxybenzophenone；[4-(2-methylprop-2-enoxy)phenyl]-phenylmethanone
• CAS: 112005-08-0
• 化学式: C₁₇H₁₆O₂
• 分子量: 252.313
• InChiKey: NSZISQULSNKJQG-UHFFFAOYSA-N

物化性质

• 熔点：
  85-86.5 °C
• 沸点：
  391.9±25.0 °C(Predicted)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(methallyloxy)benzophenone 在 吡啶 、 N,N-二乙基苯胺 作用下， 反应 5.5h， 生成 3-methallyl-4-(pivaloyloxy)benzophenone
  参考文献：
  名称：

  (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase

  摘要：

  A series of 4-(acyloxy)- and 4,4'-bis(acyloxy)benzophenones were synthesized. Some of them, pivalates (trimethylacetates) and isobutyrates in particular, were found to be potent and selective inhibitors of human neutrophil (leukocyte) elastase. A series of 2-[(acyloxy)methyl]-5-(acyloxy)-4-pyrones were synthesized regioselectively from kojic acid. The 4-pyrones bearing a long chain acyl group at the 2-position and either pivaloyloxy or isobutyryloxy at the 5-position were potent and selective inhibitors of the human elastase. A number of analogues and derivatives in both series were synthesized in order to study the structure-activity relationship as summarized in Tables I-VI and in Tables IX and X. The inhibition was selective to human neutrophil elastase. No inhibition of porcine pancreatic elastase or bovine pancreatic chymotrypsin (Tables VII and XI) was observed. The most likely mechanism of inhibition is discussed. The implication of these findings for the treatment of rheumatoid arthritis and emphysema is outlined.

  DOI：

  10.1021/jm00400a030
• 作为产物：
  描述：

  4-羟基-二苯甲酮 、 3-氯-2-甲基丙烯 在 sodium iodide 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 生成 4-(methallyloxy)benzophenone
  参考文献：
  名称：

  Phenolic ester derivatives as elastase inhibitors

  摘要：

  通式I的酚酯##STR1##可用于预防、管理或缓解弹性蛋白酶介导的疾病或症状。

  公开号：

  US04683241A1

文献信息

• Photo-curable reparative material for dental use
  申请人：——

  公开号：US20030162863A1

  公开（公告）日：2003-08-28

  A photocurable dental restorative comprising (i) 100 parts by weight of a polymerizable monomer, (ii) 0.01 to 5 parts by weight of a photopolymerization initiator of acylphosphine oxide, and (iii) 200 to 1900 parts by weight of an inorganic filler, wherein the inorganic filler (iii) is a mixed filler of: (A) irregular-shaped inorganic particles having an average particle size of not smaller than 0.1 &mgr;m but smaller than 1 &mgr;m; (B) spherical inorganic particles having an average primary particle size of not smaller than 0.1 &mgr;m but not larger than 5 &mgr;m; and (C) fine inorganic particles having an average primary particle size of not larger than 0.1 &mgr;m; which are so blended as to satisfy the following mass ratios circle over (1)} to circle over (3)}: mA /( mB+mC )=0.2 to 3  circle over (1)} mB /( mB+mC )=0.5 to 0.99  circle over (2)} mC /( mB+mC )=0.01 to 0.5  circle over (3)} where mA, mB and mC are masses of the inorganic particles (A) to (C). The restorative features excellent handling property, and makes it possible to obtain a cured product having a high fracture toughness and excellently glossy surface.

  一种光固化牙科修复材料，包括（i）100份重量的可聚合单体，（ii）0.01至5份重量的酰基膦氧化物光聚合引发剂，和（iii）200至1900份重量的无机填料，其中无机填料（iii）是以下混合填料：（A）具有平均粒径不小于0.1μm但小于1μm的不规则形状无机颗粒；（B）具有平均初级粒径不小于0.1μm但不大于5μm的球形无机颗粒；和（C）具有平均初级粒径不大于0.1μm的细微无机颗粒；这些颗粒混合以满足以下质量比圆圈1}至圆圈3}：mA/(mB+mC)=0.2至3；mB/(mB+mC)=0.5至0.99；mC/(mB+mC)=0.01至0.5；其中mA、mB和mC分别为无机颗粒（A）至（C）的质量。该修复材料具有出色的操作性能，可以获得具有高断裂韧性和极佳光泽表面的固化产品。
• UV-vernetzbare Massen auf Basis von Isoamyl(meth)acrylatcopolymerisaten
  申请人：BASF Aktiengesellschaft

  公开号：EP0367054A2

  公开（公告）日：1990-05-09

  Unter Luftsauerstoffatmosphäre durch ultraviolette Strahlung vernetzbare Massen auf der Basis von (Meth)acrylsäureester-Copolymerisaten eines K-Wertes von 10 bis 100, erhalten durch radikalische Polymerisation in Substanz oder Lösung von a) 5 bis 97,4 Gew.-% i-Amylacrylat und/oder i-Amylmethacrylat und b) 0 bis 89,9 Gew.-% (Meth)acrylsäureestern, deren Homopolymerisate eine Glasübergangstemperatur von unter -30°C haben und c) 2,5 bis 30 Gew.-% α,β-monoolefinisch ungesättigten Verbindungen, deren Homopolymerisate eine Glastemperatur von über -30°C haben und d) 0 bis 10 Gew.-% monoolefinisch ungesättigten Säuren und/oder deren Anhydriden und e) 0 bis 20 Gew.-% weiteren olefinisch ungesättigten Monomeren mit wenigstens einer der folgenden funktionellen Gruppen: Hydroxi-, Amid-, Epoxid-, Ether-, Ester-, Urethan-, Harnstoff-, prim., sek., tert. Amin und Ether und f) 0,1 bis 5 Gew.-% eines copolymerisierbaren Benzophenon- oder Acetonphenonderivates wobei die Summe der Gewichtsprozente x = a + b + c + d + f jeweils 100 beträgt.

  可在大气含氧环境下通过紫外线辐射交联的组合物，其基础是 K 值在 10 至 100 之间的（甲基）丙烯酸酯共聚物，该共聚物是在下列物质或溶液中通过自由基聚合反应获得的 a) 5 至 97.4%（重量百分比）丙烯酸 i-amyl 酯和/或甲基丙烯酸 i-amyl 酯和 b) 0 至 89.9%（按重量计）的（甲基）丙烯酸酯，其均聚物的玻璃化转变温度低于 -30°C，以及 c) 2.5%至 30%（重量百分比）的α、β-单烯不饱和化合物，其均聚物的玻璃化转变温度高于 -30°C，以及 d) 0 至 10%（按重量计）的单烯烃不饱和酸和/或其酸酐，以及 e) 0 至 20%（按重量计）的其他烯烃不饱和单体，至少具有以下一种官能团：羟基、酰胺、环氧化物、醚、酯、氨基甲酸乙酯、脲、伯、仲、叔、醚、胺和醚。胺和醚，以及 f) 0.1%至 5%（按重量计）可共聚的二苯甲酮或丙酮苯酮衍生物 在每种情况下，重量百分比 x = a + b + c + d + f 的总和为 100。
• PHOTO-CURABLE REPARATIVE MATERIAL FOR DENTAL USE
  申请人：TOKUYAMA CORPORATION

  公开号：EP1236459A1

  公开（公告）日：2002-09-04

  A photocurable dental restorative comprising (i) 100 parts by weight of a polymerizable monomer, (ii) 0.01 to 5 parts by weight of a photopolymerization initiator of acylphosphine oxide, and (iii) 200 to 1900 parts by weight of an inorganic filler, wherein the inorganic filler (iii) is a mixed filler of: (A) irregular-shaped inorganic particles having an average particle size of not smaller than 0.1 µm but smaller than 1 µm; (B) spherical inorganic particles having an average primary particle size of not smaller than 0.1 µm but not larger than 5 µm; and (C) fine inorganic particles having an average primary particle size of not larger than 0.1 µm;    which are so blended as to satisfy the following mass ratios ① to ③: ① mA/ (mB + mC) = 0.2 to 3 ② mB/(mB + mC) = 0.5 to 0.99 ③ mC/(mB + mC) = 0.01 to 0.5    where mA, mB and mC are masses of the inorganic particles (A) to (C). The restorative features excellent handling property, and makes it possible to obtain a cured product having a high fracture toughness and excellently glossy surface.

  一种光固化牙科修复体，包括(i)100 份（按重量计）可聚合单体，(ii)0.01 至 5 份（按重量计）酰基氧化膦光聚合引发剂，以及(iii)200 至 1900 份（按重量计）无机填料，其中无机填料(iii)是以下物质的混合填料： (A) 平均粒径不小于 0.1 微米但小于 1 微米的不规则无机颗粒； (B) 平均主粒径不小于 0.1 微米但不大于 5 微米的球形无机颗粒；以及 (C) 平均主要粒径不大于 0.1 微米的细无机颗粒； 混合后满足以下质量比①至③： ① mA/ (mB + mC) = 0.2 至 3 ② mB/(mB + mC) = 0.5 至 0.99 ③ mC/(mB + mC) = 0.01 至 0.5 其中 mA、mB 和 mC 为无机颗粒（A）至（C）的质量。 该修复剂具有极佳的操作性能，可获得具有高断裂韧性和极佳表面光泽的固化产品。
• Removable pressure-sensitive adhesive composition and pressure-sensitive adhesive tape or sheet
  申请人：NITTO DENKO CORPORATION

  公开号：EP1930386A2

  公开（公告）日：2008-06-11

  The present invention relates to a removable pressure-sensitive adhesive composition containing an acrylic polymer, a photopolymerization initiator and a crosslinking agent, in which the acrylic polymer and the photopolymerization initiator each are chemically bonded to the crosslinking agent. The present invention also relates to a removable pressure-sensitive adhesive composition containing an acrylic polymer and a photopolymerization initiator, the composition further containing a crosslinking agent having a reactive functional group which is capable of reacting with a reactive functional group of the acrylic polymer and a reactive functional group of the photopolymerization initiator.

  本发明涉及一种含有丙烯酸聚合物、光聚合引发剂和交联剂的可移除压敏胶组合物，其中丙烯酸聚合物和光聚合引发剂分别与交联剂化学键合。本发明还涉及一种含有丙烯酸聚合物和光聚合引发剂的可移除压敏胶组合物，该组合物还含有一种具有活性官能团的交联剂，该活性官能团能够与丙烯酸聚合物的活性官能团和光聚合引发剂的活性官能团反应。
• PHOTOPOLYMERIZABLE COMPOSITIONS
  申请人：Tokuyama Dental Corporation

  公开号：EP2280032A1

  公开（公告）日：2011-02-02

  Disclosed are photopolymerizable compositions suitable for uses such as dental composite resins, and that comprise (A) a radical-polymerizable monomer, (B) a photopolymerization initiator that comprises (B1) an α-diketone compound, (B2) a photoacid generating agent, (B3) an aromatic amine compound, and (C) an organic filler containing a phthalate ester fluorescent agent.

  本发明公开了适用于牙科复合树脂等用途的可光聚合组合物，该组合物包括 (A) 可自由基聚合的单体；(B) 光聚合引发剂，该引发剂包括 (B1) α-二酮化合物；(B2) 光酸生成剂；(B3) 芳香族胺化合物；以及 (C) 含有邻苯二甲酸酯类荧光剂的有机填料。