bis(4-fluorobenzyl) sulfide | 69719-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(4-fluorobenzyl) sulfide
• 英文别名: bis(4-fluorobenzyl)sulfide；1,1'-[thiobis(methylene)]bis[4-fluorobenzene]；Bis-(p-fluorobenzyl)sulfid；1-Fluoro-4-[(4-fluorophenyl)methylsulfanylmethyl]benzene
• CAS: 69719-54-6
• 化学式: C₁₄H₁₂F₂S
• 分子量: 250.312
• InChiKey: YYMBJIMAVVGTAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对氟苯甲醛 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 indium (III) iodide 、 1,1,3,3-四甲基二硅氧烷 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 10.0h， 以78%的产率得到bis(4-fluorobenzyl) sulfide
  参考文献：
  名称：

  Indium(Iii)-Catalyzed Reductive One-Pot Synthesis of Thioethers from Aromatic Aldehydes and Elemental Sulfur

  摘要：

  Described herein is that a combination of InI3 and 1,1,3,3-tetramethyldisiloxane (TMDS) effectively promotes the reductive thioetherification from aromatic aldehydes with elemental sulfur (S-8).

  DOI：

  10.1080/10426507.2015.1036990

文献信息

• (E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
  申请人：——

  公开号：US20030149109A1

  公开（公告）日：2003-08-07

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

  使用α,β-不饱和芳基磺酮进行预处理可以保护正常细胞免受两类抗癌化疗药物的细胞毒副作用。在患者进行含细胞周期有丝分裂期抑制剂或拓扑异构酶抑制剂的抗癌化疗之前，给予一种细胞保护性磺酮化合物，可以减少或消除抗癌药物对正常细胞的细胞毒副作用。α,β-不饱和芳基磺酮的细胞保护作用使得临床医生可以安全地增加抗癌化疗药物的剂量。
• [EN] 24-SULFOXIMINE VITAMIN D3 COMPOUNDS<br/>[FR] COMPOSES DE TYPE 24-SULFOXIMINE VITAMINE D3
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2003106411A1

  公开（公告）日：2003-12-24

  The present invention provides novel sulfoximine compounds, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1α,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.

  本发明提供了新型亚砜胺化合物，包括这些化合物的组合物以及使用这些化合物作为CYP24抑制剂的方法。特别是，本发明的化合物对于治疗受益于调节1α,25-二羟基维生素D3水平的疾病非常有用，例如细胞增殖性疾病。
• Indium-catalyzed Direct Conversion of Dibenzyl Ethers to Dibenzyl Sulfides Using Elemental Sulfur and a Hydrosilane and Its Application to the Preparation of Benzyl Selenides
  作者：Norio Sakai、Koji Takada、Masahiro Katayama、Yohei Ogiwara

  DOI：10.1246/cl.180242

  日期：2018.6.5

  compound, a hydrosilane and an easily handled form of elemental sulfur (S8) that effectively and directly catalyzes the sulfidation of dibenzyl ethers to produce dibenzyl sulfides. This system could also be applied to selenium in a straightforward conversion to dibenzyl selenides.

  本文描述了由铟(III)化合物、氢硅烷和易于处理的元素硫(S8)形式组成的催化体系，其有效且直接地催化二苄基醚硫化以产生二苄基硫化物。该系统也可以直接转化为二苄基硒化物而应用于硒。
• Indium-catalyzed direct preparation of dibenzyl sulfides from benzyl alcohols and elemental sulfur with a hydrosilane and its application to the preparation of dibenzyl selenide
  作者：Takahiro Miyazaki、Masahiro Katayama、Shunsuke Yoshimoto、Yohei Ogiwara、Norio Sakai

  DOI：10.1016/j.tetlet.2015.12.109

  日期：2016.2

  system composed of InI3 and a hydrosilane efficiently and directly introduce elemental sulfur into the structure of dibenzyl sulfides via a nucleophilic substitution of benzyl alcohols. Also, we describe the application of this reducing system in the direct preparation of a dibenzyl selenide derivative with selenium.

  我们描述了一种由InI 3和氢硅烷组成的还原体系如何有效地通过苄醇的亲核取代将元素硫直接引入二苄硫的结构中。另外，我们描述了该还原体系在直接制备具有硒的二苄基硒化物衍生物中的应用。
• Azaindole derivatives useful as cholesterol biosynthesis inhibitors
  申请人：Sandoz Pharm. Corp.

  公开号：US04939159A1

  公开（公告）日：1990-07-03

  Compounds of the formula I: ##STR1## wherein X is the residue of an unsubstituted 6-membered aromatic ring having 3 carbon atoms and one nitrogen atom; R.sup.1 is C.sub.1-6 primary alkyl (free of asymmetric carbon atoms), or isopropyl; R.sup.2 is substituted or unsubstituted phenyl, primary or secondary C.sub.1-6 alkyl (free of asymmetric carbons), C.sub.3-6 cycloalkyl or phenalkyl as defined in the Specification ##STR2## in which R.sup.8 is hydrogen, R.sup.9 or M, wherein R.sup.9 is a physiologically acceptable and hydrolyzable ester group, and M is a pharmaceutically acceptable cation; are obtained by multi-step processes and are useful as cholesterol biosynthesis inhibitors. 3

  公式I的化合物：##STR1## 其中X是未取代的6元芳环残基，具有3个碳原子和一个氮原子；R1是C1-6一级烷基（不含不对称碳原子），或异丙基；R2是取代或未取代的苯基，一级或二级C1-6烷基（不含不对称碳原子），C3-6环烷基或按规范定义的苯基烷基##STR2## 其中R8是氢，R9或M，其中R9是生理上可接受和水解酯基，M是药理学上可接受的阳离子。这些化合物是多步反应得到的，并且可用作胆固醇生物合成抑制剂。