Conjugated trienes are ubiquitous structures in natural products and organic functional molecules. An efficient 1,4-palladium migration/Heck sequence was developed for the highly stereoselective synthesis of trisubstituent 1,3,5-trienes, which were found to undergo easy E/Z isomerization in the presence of light.
共轭
三烯是
天然产物和有机功能分子中的普遍结构。开发了一种高效的1,4-
钯迁移/ Heck序列,用于高度立体选择性地合成三取代1,3,5-
三烯,发现在光的存在下容易进行E / Z异构化。