(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(2-hydroxyethyl)hepta-1,6-diene-3,5-dione | 1111745-10-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(2-hydroxyethyl)hepta-1,6-diene-3,5-dione
• CAS: 1111745-10-8
• 化学式: C₂₅H₂₈O₇
• 分子量: 440.493
• InChiKey: GADYSGAAASKGCK-NXZHAISVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  ASC-J9; 二甲基姜黄素 、 2-溴乙醇 在 四丁基溴化铵 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.17h， 生成 (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(2-hydroxyethyl)hepta-1,6-diene-3,5-dione
  参考文献：
  名称：

  WO2008/85984

  摘要：

  公开号：

文献信息

• Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and use thereof
  申请人：Shih Charles C.Y.

  公开号：US20080188557A1

  公开（公告）日：2008-08-07

  The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, acne, alopecia, hirsutism, a wound, prostate cancer, bladder cancer, liver cancer, breast cancer and Kennedy's disease.

  本发明涉及具有至少一个（取代苯基）-丙烯醛基团的化合物、药物和化妆品。本发明的化合物和组合物在治疗或预防医疗状况方面是有用的，包括与雄激素相关的疾病、雄激素相关的炎症、痤疮、脱发、多毛症、伤口、前列腺癌、膀胱癌、肝癌、乳腺癌和肯尼迪病。
• COMPOUNDS WITH (SUBSTITUTED PHENYL)-PROPENAL MOIETY, THEIR DERIVATIVES, BIOLOGICAL ACTIVITY, AND USE THEREOF
  申请人：Allianz Pharmascience Ltd

  公开号：EP2993165A2

  公开（公告）日：2016-03-09

  The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of many medical conditions such as androgen associated conditions. The present invention also includes methods of treating a medical condition including an androgen associated condition, using at least one of the disclosed compounds.

  本发明包括至少具有一个（取代苯基）-丙烯醛分子的化合物、药品和化妆品。本发明的化合物和组合物可用于治疗或预防多种疾病，如雄激素相关疾病。本发明还包括使用至少一种已公开化合物治疗包括雄激素相关病症在内的病症的方法。
• Compositions including androgen receptor degradation (ARD) enhancers and methods of prophylactic or therapeutic treatment of skin disorders and hair loss
  申请人：Shih Charles C.Y.

  公开号：US20090035362A1

  公开（公告）日：2009-02-05

  The present invention includes methods and compositions useful for treating and preventing skin disorders, hair loss and other skin disorders. The compositions include an ARD enhancer in combination with a second compound or composition. In some embodiments the second compound is at least one of a bactericide, an antibiotic, an anti-microbial peptide, Vitamin A, a Vitamin A derivative, a retinoid, an anti-inflammatory compound, and anti-androgen compounds.
• US8202905B2
  申请人：——

  公开号：US8202905B2

  公开（公告）日：2012-06-19