tetramethyl-1,4,5,6 pyrimidinone-2 | 78365-50-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: tetramethyl-1,4,5,6 pyrimidinone-2
• 英文别名: 1,4,5,6-tetramethyl-2-pyrimidone；1,4,5,6-tetramethyl-1H-pyrimidin-2-one；1,4,5,6-Tetramethylpyrimidin-2-on；1,4,5,6-tetramethylpyrimidin-2-one
• CAS: 78365-50-1
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: JGBAGJIFEWOXCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tetramethyl-1,4,5,6 pyrimidinone-2 在 乙酸盐 作用下， 以 重水 为溶剂， 生成 1,4,5-Trimethyl-6-methylene-1,6-dihydro-pyrimidin-2-ol anion
  参考文献：
  名称：

  Effect of neighboring alkyl groups on the rate of proton loss in methylpyrimidine derivatives

  摘要：

  DOI：

  10.1021/jo00132a018
• 作为产物：
  描述：

  3-甲基-2,4-戊烷二酮 、 N-甲基脲 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 85.0h， 以26.5%的产率得到tetramethyl-1,4,5,6 pyrimidinone-2
  参考文献：
  名称：

  Picquenard, Eric; Dizabo, Pierre, Canadian Journal of Chemistry, 1981, vol. 59, p. 1270 - 1276

  摘要：

  DOI：

文献信息

• Compounds and Pharmaceutical Compositions for the Treatment of Viral Infections
  申请人：SOMMADOSSI Jean-Pierre

  公开号：US20090238790A2

  公开（公告）日：2009-09-24

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病，包括HCV和/或HBV感染的化合物、组合物和方法。具体来说，披露了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• Compounds and pharmaceutical compositions for the treatment of viral infections
  申请人：Sommadossi Jean-Pierre

  公开号：US20080286230A1

  公开（公告）日：2008-11-20

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病，包括HCV和/或HBV感染的化合物、组合物和方法。具体地，本文公开了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：SOMMADOSSI Jean-Pierre

  公开号：US20110286962A1

  公开（公告）日：2011-11-24

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了治疗肝脏疾病，包括HCV和/或HBV感染的化合物、组合物和方法。具体地，揭示了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• Compounds and Pharmaceutical compositions for the treatment of Viral infections
  申请人：Sommadossi Jean-Pierre

  公开号：US20090169504A1

  公开（公告）日：2009-07-02

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病，包括HCV和/或HBV感染的化合物，组合物和方法。具体地，公开了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• Modified 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections
  申请人：LaColla Paola

  公开号：US20070027065A1

  公开（公告）日：2007-02-01

  2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.