diethyl (2-(1-methyl-1H-indazole-3-carbonyl)hydrazinyl)(2-nitrophenyl)methylphosphonate | 1369597-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: diethyl (2-(1-methyl-1H-indazole-3-carbonyl)hydrazinyl)(2-nitrophenyl)methylphosphonate
• 英文别名: N'-[diethoxyphosphoryl-(2-nitrophenyl)methyl]-1-methylindazole-3-carbohydrazide
• CAS: 1369597-42-1
• 化学式: C₂₀H₂₄N₅O₆P
• 分子量: 461.414
• InChiKey: OLIVBDBQOMGWKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-甲基-3-吲唑甲酸 在 三甲基氯硅烷 、 硫酸 、 一水合肼 、 溶剂黄146 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 18.0h， 生成 diethyl (2-(1-methyl-1H-indazole-3-carbonyl)hydrazinyl)(2-nitrophenyl)methylphosphonate
  参考文献：
  名称：

  Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity

  摘要：

  We are reporting herein for the first time the synthesis of alpha-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl-1H-indazole-3-carbohydrazide are synthesized and in the next step it has converted to alpha-aminophosphonates using chlorotrimethylsilane (TMSCI) and triethyl phosphite. Some of the synthesized derivatives are evaluated for antibacterial activity against different bacterial strains. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.024

文献信息

• Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity
  作者：Nasir ali Shafakat Ali、Shaikh Zakir、Muqtadir Patel、Mazahar Farooqui

  DOI：10.1016/j.ejmech.2012.01.024

  日期：2012.4

  We are reporting herein for the first time the synthesis of alpha-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl-1H-indazole-3-carbohydrazide are synthesized and in the next step it has converted to alpha-aminophosphonates using chlorotrimethylsilane (TMSCI) and triethyl phosphite. Some of the synthesized derivatives are evaluated for antibacterial activity against different bacterial strains. (C) 2012 Elsevier Masson SAS. All rights reserved.