N2-(Phenylmethyl)lysine | 911319-77-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N2-(Phenylmethyl)lysine
• 英文别名: 6-amino-2-(benzylamino)hexanoic acid
• CAS: 911319-77-2
• 化学式: C₁₃H₂₀N₂O₂
• 分子量: 236.31
• InChiKey: GFQYFRTWQLDRCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Uses Of Cyclic Peptides For Treating And Preventing Atherosclerosis Uses of Cyclic Peptides for Treating and Preventing Atherosclerosis
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US20160250280A1

  公开（公告）日：2016-09-01

  The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis. Further provided in the invention are methods of screening for anti-atherosclerotic cyclic peptides with improved properties.

  本发明提供了循环化合物，可用于预防或治疗动脉粥样硬化或相关疾病。本发明还提供了治疗各种与动脉粥样硬化相关或介导的疾病或疾病的治疗方法。本发明还提供了筛选具有改进性能的抗动脉粥样硬化循环肽的方法。
• Uses of cyclic peptides for treating and preventing atherosclerosis
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US10092620B2

  公开（公告）日：2018-10-09

  The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis. Further provided in the invention are methods of screening for anti-atherosclerotic cyclic peptides with improved properties.

  本发明提供了可用于预防或治疗动脉粥样硬化或相关疾病的环状化合物。本发明还提供了治疗或预防与动脉粥样硬化相关或由动脉粥样硬化介导的各种疾病或紊乱的治疗方法。本发明还提供了筛选具有改进性质的抗动脉粥样硬化环肽的方法。
• PROCESS FOR THE PREPARATION GLATIRAMER ACETATE (COPOLYMER-1)
  申请人：Natco Pharma Limited

  公开号：EP2173766A1

  公开（公告）日：2010-04-14
• USES OF CYCLIC PEPTIDES FOR TREATING AND PREVENTING ATHEROSCLEROSIS
  申请人：The Scripps Research Institute

  公开号：EP2981277A2

  公开（公告）日：2016-02-10
• Non-natural amino acids and neurotensin analogues
  申请人：Brower Justin O.

  公开号：US20080234202A1

  公开（公告）日：2008-09-25

  This invention relates to methods of synthesis of amino acid analogs contained within peptide sequences that is adapted for preparation of peptides containing analogs of basic amino acids lysine and arginine.