Diethoxyphosphoryl-[2-(dimethylamino)phenyl]methanol | 1253528-68-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Diethoxyphosphoryl-[2-(dimethylamino)phenyl]methanol
• CAS: 1253528-68-5
• 化学式: C₁₃H₂₂NO₄P
• 分子量: 287.296
• InChiKey: CWIWJFDKHGLAOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二乙基亚磷酸氢酯 、 2-(N,N-二甲氨基)苯甲醛 在 [(Me₃Si)₂N]₃La(μ-Cl)Li(THF)₃ 作用下， 以 甲苯 为溶剂， 反应 0.25h， 以92%的产率得到Diethoxyphosphoryl-[2-(dimethylamino)phenyl]methanol
  参考文献：
  名称：

  Lanthanide Amides [(Me₃Si)₂N]₃Ln(μ-Cl)Li(THF)₃ Catalyzed Hydrophosphonylation of Aryl Aldehydes

  摘要：

  A highly efficient method for the synthesis of alpha-hydroxy phosphonates via lanthanide amides [(Me3Si)(2)N](3)Ln(mu-Cl)Li(THF)(3) catalyzed hydrophosphonylation of aromatic aldehydes was developed. The reactions produced the products in excellent yields in the presence 0.1 mol % [(Me3Si)(2)N](3)Ln(mu-Cl)Li(THF)(3) at room temperature within 5 min. The existence of LiCl in the catalyst was a key factor affecting the catalytic activity. The mechanism for the process of high efficiency was proposed.

  DOI：

  10.1021/jo101743e

文献信息

• Lanthanide Amides [(Me₃Si)₂N]₃Ln(μ-Cl)Li(THF)₃ Catalyzed Hydrophosphonylation of Aryl Aldehydes
  作者：Qingmao Wu、Jun Zhou、Zhigang Yao、Fan Xu、Qi Shen

  DOI：10.1021/jo101743e

  日期：2010.11.5

  A highly efficient method for the synthesis of alpha-hydroxy phosphonates via lanthanide amides [(Me3Si)(2)N](3)Ln(mu-Cl)Li(THF)(3) catalyzed hydrophosphonylation of aromatic aldehydes was developed. The reactions produced the products in excellent yields in the presence 0.1 mol % [(Me3Si)(2)N](3)Ln(mu-Cl)Li(THF)(3) at room temperature within 5 min. The existence of LiCl in the catalyst was a key factor affecting the catalytic activity. The mechanism for the process of high efficiency was proposed.