Phosphoramidic acid, 2,5-xylyl-, diethyl ester (8CI) | 22846-97-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phosphoramidic acid, 2,5-xylyl-, diethyl ester (8CI)
• 英文别名: N-diethoxyphosphoryl-2,5-dimethylaniline
• CAS: 22846-97-5
• 化学式: C₁₂H₂₀NO₃P
• 分子量: 257.269
• InChiKey: ODAYIJXUKBMRIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,5-二甲基硝基苯 、 亚磷酸三乙酯 以 甲苯 为溶剂， 200.0 ℃ 、2.0 MPa 条件下， 反应 0.25h， 以75%的产率得到Phosphoramidic acid, 2,5-xylyl-, diethyl ester (8CI)
  参考文献：
  名称：

  Practical and reliable synthesis of dialkyl N-arylphosphoramidates with nitroarenes as substrates

  摘要：

  A new single-step transformation of readily available nitroarenes with trialkyl phosphites, which can be performed both under thermal and microwave conditions, delivers dialkyl N-arylphosphoramidates in good yields and short reaction times. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.037

文献信息

• Photochemical deoxygenation of aromatic nitro compounds in triethyl phosphite. Substituent effects and evidence for the involvement aryl nitrenes
  作者：Richard J. Sundberg、Bijan P. Das、Richard Holladay Smith

  DOI：10.1021/ja01031a024

  日期：1969.1
• Practical and reliable synthesis of dialkyl N-arylphosphoramidates with nitroarenes as substrates
  作者：Reda Haggam、Jürgen Conrad、Uwe Beifuss

  DOI：10.1016/j.tetlet.2009.09.037

  日期：2009.12

  A new single-step transformation of readily available nitroarenes with trialkyl phosphites, which can be performed both under thermal and microwave conditions, delivers dialkyl N-arylphosphoramidates in good yields and short reaction times. (C) 2009 Elsevier Ltd. All rights reserved.