phenoxy-malonic acid | 2272-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenoxy-malonic acid
• 英文别名: Phenoxy-malonsaeure；Phenoxymalonsaeure；2-Phenoxypropanedioic acid
• CAS: 2272-13-1
• 化学式: C₉H₈O₅
• 分子量: 196.16
• InChiKey: HVQAHNBSEFQMPZ-UHFFFAOYSA-N

物化性质

• 熔点：
  96 °C
• 沸点：
  376.8±27.0 °C(Predicted)
• 密度：
  1.441±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sodium phenoxide 在 氢氧化钾 、 乙醇 作用下， 生成 phenoxy-malonic acid
  参考文献：
  名称：

  Disproportionation in Aryloxymalonic Acid Syntheses

  摘要：

  DOI：

  10.1021/ja01862a046

文献信息

• Polyphenylene ether resin composition
  申请人：MITSUBISHI PETROCHEMICAL CO., LTD.

  公开号：EP0282052A2

  公开（公告）日：1988-09-14

  A polyphenylene ether resin composition comprising (a) a polyphenylene ether resin, (b) a polyester resin, and (c) from 0.1 to 10 parts by weight, per 100 parts by weight of the total of the components (a) and (b), an epoxidized liquid polybutadiene having an oxirane oxygen content of at least 0.07% by weight. The composition is excellent in solvent resistance and mechanical strength.

  一种聚苯醚树脂组合物，由以下组分组成：(a) 聚苯醚树脂；(b) 聚酯树脂；(c) 以每 100 份组分(a)和(b)的总重量计，0.1 至 10 份环氧乙烷化液态聚丁二烯，其环氧乙烷氧含量至少为 0.07%。 该组合物具有优异的耐溶剂性和机械强度。
• Polysaccharide modification in densified fluid
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP0893451A2

  公开（公告）日：1999-01-27

  This invention relates to a process for chemically modifying polysaccharides in a densified fluid. In particular, the modification includes esterification and/or etherification of a starch in supercritical carbon dioxide. The process is advantageous in that it allows for a high degree of substitution without the use of organic solvents or repeated reactions.

  本发明涉及一种在致密流体中对多糖进行化学修饰的工艺。特别是，这种改性包括在超临界二氧化碳中对淀粉进行酯化和/或醚化。该工艺的优点是可以在不使用有机溶剂或重复反应的情况下进行高度置换。
• SURGICAL ADJUNCTS HAVING MEDICANTS CONTROLLABLY RELEASABLE THEREFROM
  申请人：Ethicon Endo-Surgery, LLC

  公开号：EP3138589A1

  公开（公告）日：2017-03-08

  Surgical adjuncts having medicants controllably releasable therefrom are provided. In general, an adjunct retaining at least one medicant controllably releasable therefrom can be configured to be responsive to one or more physiological triggers. The adjunct can be provided with the at least one medicant releasably retained within the adjunct. In general, the one or more physiological triggers can each include an environmental condition to which the adjunct is exposed, such as when the adjunct is positioned within a body, such as by being stapled to tissue. Various physiological triggers can affect the adjunct, causing the adjunct to release the at least one medicant to the surrounding tissue in a selectable elution profile depending on the physiological trigger(s) that affect a particular adjunct.

  提供了具有可控释放药剂的手术辅助器械。一般来说，至少一种药剂可控释放的辅助器械可配置为响应一个或多个生理触发器。该辅助装置可提供可释放地保留在辅助装置内的至少一种药剂。一般来说，一个或多个生理触发器可分别包括附属装置所暴露的环境条件，例如当附属装置被放置在体内时，如被钉在组织上。各种生理触发器都会影响附属装置，导致附属装置根据影响特定附属装置的生理触发器，以可选择的洗脱曲线向周围组织释放至少一种药剂。
• Zwitterionic surfactant containing ethoxylate units
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US10479762B1

  公开（公告）日：2019-11-19

  Zwitterionic surfactants having a sulfonate head group and an ethoxylated alkyl tail. A method for synthesizing the surfactants via amidation of an ethoxylated carboxylic acid and an amine catalyzed by a fluoride salt as well as a sulfonation reaction using a sultone is provided.

  具有磺酸头基和乙氧基化烷基尾基的表面活性剂。本发明提供了一种通过乙氧基化羧酸和胺在氟化盐催化下发生酰胺化反应以及使用一种磺化酮发生磺化反应来合成这种表面活性剂的方法。
• Medicant eluting adjuncts and methods of using medicant eluting adjuncts
  申请人：Ethicon Endo-Surgery, LLC

  公开号：US10569071B2

  公开（公告）日：2020-02-25

  Various exemplary devices and methods are provided for performing surgical procedures. In general, one or more adjuncts can be used in conjunction with surgical instruments. The adjunct(s) can have medicant(s) thereon and/or therein. The medicant(s) can vary depending on the desired effect of the medicant(s) on surrounding tissue. As a non-limiting example, medicant(s) can be provided to influence hemostasis, inflammation, macrophages, and/or fibroblasts. When used in conjunction with a surgical stapler, the adjunct(s) can be disposed between and/or on jaws of the stapler, incorporated into a staple cartridge disposed in the jaws, or otherwise placed in proximity to the staples. When staples are deployed, the adjunct(s) can remain at the treatment site with the staples.

  提供了用于执行外科手术的各种示例设备和方法。一般来说，一种或多种辅助装置可与手术器械配合使用。辅助装置上和/或其中可含有药剂。药剂可根据对周围组织的预期效果而变化。作为一个非限制性的例子，药剂可用于影响止血、炎症、巨噬细胞和/或成纤维细胞。当与手术订书机结合使用时，辅助剂可放置在订书机的钳口之间和/或钳口上，与放置在钳口中的订书针盒结合在一起，或以其他方式放置在订书针附近。订书机展开时，辅助装置可与订书机一起留在治疗部位。