Triphenylphosphine oxide hemihydrate | 127486-94-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Triphenylphosphine oxide hemihydrate
• 英文别名: diphenylphosphorylbenzene;hydrate
• CAS: 127486-94-6
• 化学式: C36H32O3P2
• 分子量: 574.6
• InChiKey: GTEUZTYCMFLEND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0374952A2

  公开（公告）日：1990-06-27

  7-Oxabicycloheptane substituted prostaglandin analogs which are thromboxane A2 (TxA2) receptor antagonists or combined thromboxane A2 receptor antagonists/thromboxane synthase inhibitors useful, for example, in treating thrombotic and vasospastic disease have the structural formula wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4; Z is -(CH2)2- or -CH=CH-, with the proviso when Z is -CH = CH-, n is 1, 2, 3 or 4; R is C02H, CO2lower alkyl, CH2OH, CO2alkali metal, CONHSOR3, CONHR3a or -CH2-5-tetrazolyl, X is 0, S or NH; and where R1, R2, R3 and R3a are as defined herein.

  7-氧杂双环庚烷取代的前列腺素类似物是血栓素 A2（TxA2）受体拮抗剂或血栓素 A2 受体拮抗剂/血栓素合成酶联合抑制剂，可用于治疗血栓性疾病和血管痉挛性疾病等，其结构式为 其中 m 是 1、2 或 3；n 是 0、1、2、3 或 4；Z 是-(CH2)2- 或-CH=CH-，但当 Z 是-CH=CH-时，n 是 1、2、3 或 4；R 是 C02H、 lower 烷基、 OH、CO2 碱金属、CONHSOR3、CONHR3a 或- -5-四唑基，X 是 0、S 或 NH；其中 R1、R2、R3 和 R3a 如本文所定义。
• 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasopastic disease
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0403090A1

  公开（公告）日：1990-12-19

  7-Oxabicycloheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula wherein m is 1, 2 or 3; n is 1, 2 or 3 and p is 1, 2 or 3; R is C02H, CO2lower alkyl, CO2alkali metal, CONHS02 R2 (wherein R2 is lower alkyl or aryl) or 5-tetrazolyl; A is CHOH, C=O, (wherein R3 is H or lower alkyl), or a single bond; R, is lower alkyl, aryl, cycloalkyl or H, R1 can be H only when A is a single bond.

  7-氧杂双环庚烷咪唑类前列腺素类似物可用于治疗血栓性疾病和血管痉挛性疾病，其结构式为 其中m为1、2或3；n为1、2或3，p为1、2或3；R为C02H、CO2低级烷基、 碱金属、CONHS02 R2（其中R2为低级烷基或芳基）或5-四唑基；A为CHOH、C=O、 (其中 R3 为 H 或低级烷基）或单键；R 为低级烷基、芳基、环烷基或 H，R1 只有在 A 为单键时才可以是 H。
• 7-Oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic diseases
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0447188A2

  公开（公告）日：1991-09-18

  7-Oxabicycoheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula wherein m is 0, 1, 2, 3 or 4; n is 1, 2 or 3; and p is 1, 2 or 3; Z is -CH=CH-, -CH2CH2- or wherein Y is 0 or a single bond ; R is C02H, CO2lower alkyl, C02alkali metal, CONHS02R2 (wherein R2 is lower alkyl or aryl) or -CH2-5-tetrazolyl; A is CHOH, C=O, (wherein R3 is H or lower alkyl), or a single bond ; R1 is lower alkyl, aryl, cycloalkyl or H, R1 can be H only when A is a single bond.

  提供了可用于治疗血栓性和血管痉挛性疾病的 7-氧杂双环庚烷咪唑前列腺素类似物，其结构式为 其中m是0、1、2、3或4；n是1、2或3；p是1、2或3；Z是-CH=CH-、- -或- -。 其中 Y 是 0 或单键；R 是 C02H、CO2lower 烷基、C02 碱金属、CONHS02R2（其中 R2 是低级烷基或芳基）或 -CH2-5-四唑基；A 是 CHOH、C=O、 (其中 R3 为 H 或低级烷基）或单键；R1 为低级烷基、芳基、环烷基或 H，只有当 A 为单键时，R1 才可以是 H。
• 7-Oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0476994A1

  公开（公告）日：1992-03-25

  7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is -(CH₂)₂-, -CH=CH- or wherein Y is O, a single bond or vinyl, with the proviso that when n is O, if Z is then Y cannot be O, and when Z is -CH=CH-, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO₂H, CO₂lower alkyl, CH₂OH, CO₂alkali metal, CONHSOR³, CONHR3a or -CH₂-5-tetrazolyl, X is O, S or NH; and where R¹, R², R³ and R3a are as defined herein.

  可用于治疗血栓性和血管痉挛性疾病的 7-氧杂双环庚烷取代的前列腺素类似物的结构式为 其中 m 是 1、2 或 3；n 是 1、2、3 或 4；Z 是-(CH₂)₂-、-CH=CH- 或-(CH₂)₂-。 其中 Y 是 O、单键或乙烯基，但当 n 是 O 时，如果 Z 是 则 Y 不能为 O，当 Z 为-CH=CH-时，n 为 1、2、3 或 4；当 Y= 乙烯基时，n=0；R 为 CO₂H、CO₂低级烷基、CH₂OH、CO₂碱金属、CONHSOR³、CONHR3a 或-CH₂-5-四唑基，X 为 O、S 或 NH；其中 R¹、R²、R³ 和 R3a 如本文所定义。
• US4977174A
  申请人：——

  公开号：US4977174A

  公开（公告）日：1990-12-11