O2CC6H4NH2-m(1-) | 2906-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O2CC6H4NH2-m(1-)
• 英文别名: 3-aminobenzoate；3-amino-benzoic acid; deprotonated form；m-Aminobenzoesaeure-Anion
• CAS: 2906-33-4
• 化学式: C₇H₆NO₂
• 分子量: 136.13
• InChiKey: XFDUHJPVQKIXHO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 O2CC6H4NH2-m(1-) 以 氯仿 为溶剂， 以15%的产率得到2{(C6H5C6H5)2Cr}O2CC6H4NH2-m.*HO2CC6H4NH2-m.
  参考文献：
  名称：

  Hein, F.; Schwartzkopff, O.; Hoyer, K., Berichte der Deutschen Chemischen Gesellschaft, 1928, vol. 61, p. 730 - 753

  摘要：

  DOI：

文献信息

• Immugenic compositions and diagnostic and therapeutic uses thereof
  申请人：Zhang Zaihui

  公开号：US20050272709A1

  公开（公告）日：2005-12-08

  Pharmaceutical compositions and compounds are provided. The compounds of the invention deomonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

  本发明提供了制药组合物和化合物。本发明的化合物表现出抗增殖活性，并可能促进缺乏正常细胞周期和死亡调节的细胞凋亡。在本发明的一种实施例中，提供了化合物与生理可接受载体的制药组合物。这些制药组合物可用于治疗高增殖性疾病，包括肿瘤生长、淋巴增殖性疾病、血管生成等疾病。本发明的化合物是取代的吡唑和吡唑啉。
• Pyrazole compounds
  申请人：——

  公开号：US20020042501A1

  公开（公告）日：2002-04-11

  Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

  本发明提供了药物组合物和化合物。本发明的化合物具有抗增殖活性，并可促进细胞凋亡，特别是对于缺乏正常细胞周期和死亡调节的细胞。在本发明的一种实施例中，提供了与生理可接受载体结合的化合物制剂。这些药物配方对于治疗高增殖性疾病非常有用，这些疾病包括肿瘤生长、淋巴增殖性疾病和血管生成等疾病。本发明的化合物是取代的吡唑和吡唑烷。
• PYRIMIDINYL-THIOPHENE KINASE MODULATORS
  申请人：Arnold D. William

  公开号：US20070117800A1

  公开（公告）日：2007-05-24

  The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.

  本发明提供了新型嘧啶基-噻吩激酶调节剂以及使用这些新型嘧啶基-噻吩激酶调节剂治疗由激酶活性介导的疾病的方法。
• Hydrazonopyrazole derivatives and their use as therapeutics
  申请人：Valocor Therapeutics, Inc.

  公开号：US07875728B2

  公开（公告）日：2011-01-25

  Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

  本发明提供了药物组合物和化合物。本发明的化合物表现出抗增殖活性，并可能促进缺乏正常细胞周期和死亡调节的细胞凋亡。在本发明的一种实施例中，提供了化合物与生理上可接受的载体组合的药物组合物。这些药物组合物在治疗增生性疾病方面是有用的，这些疾病包括肿瘤生长，淋巴增生性疾病和血管生成。本发明的化合物是取代的吡唑和吡唑烷。
• Pyrimidinyl-thiophene kinase modulators
  申请人：SGX Pharmaceuticals, Inc.

  公开号：US07977481B2

  公开（公告）日：2011-07-12

  The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.

  本发明提供了新型嘧啶基-噻吩激酶调节剂及其使用方法，用于治疗由激酶活性介导的疾病。