Antibacterial activity is exhibited by 3-acylamino-2-azeti- jinones having in the 1-position a group of the formula
3- 乙酰氨基-2-氮杂环丁酮具有抗菌活性,其 1 位上的基团式如下
Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues
作者:Arnaud LeTiran、James P Stables、Harold Kohn
DOI:10.1016/s0968-0896(01)00204-8
日期:2001.10
Proven conformationallyrestricted analogues of anticonvulsant functionalized aminoacids (FAAs) were prepared using short-range cyclizations and evaluated in pharmacological assays providing new information concerning the structural requirements for FAA function.