2-chloro-4-phenoxyphenol | 54582-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-4-phenoxyphenol
• CAS: 54582-59-1
• 化学式: C₁₂H₉ClO₂
• 分子量: 220.655
• InChiKey: OEHWUFIZHYKWIG-UHFFFAOYSA-N

物化性质

• 沸点：
  324.0±32.0 °C(Predicted)
• 密度：
  1.294±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-4-phenoxyphenol 在 sodium hydroxide 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 异丙醇 为溶剂， 反应 5.0h， 生成 7-(3-(2-Chloro-4-phenoxyphenoxy)propoxy)-2-ethylchromane-2-carboxylic acid
  参考文献：
  名称：

  (2R)-2-Ethylchromane-2-carboxylic Acids:  Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents

  摘要：

  A series of chromane-2-carboxylic acid derivatives was synthesized and evaluated for PPAR agonist activities. A structure-activity relationship was developed toward PPARalpha/gamma dual agonism. As a result, (2R)-7-{3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy}-2-ethylchromane-2-carboxylic acid (48) was identified as a potent, structurally novel, selective PPARalpha/gamma dual agonist. Compound 48 exhibited substantial antihyperglycemic and hypolipidemic activities when orally administered in three different animal models: the db/db mouse type 2 diabetes model, a Syrian hamster lipid model, and a dog lipid model.

  DOI：

  10.1021/jm030621d
• 作为产物：
  描述：

  4-苯氧基苯酚 在 磺酰氯 作用下， 生成 2-chloro-4-phenoxyphenol
  参考文献：
  名称：

  Synthesis of mono- and bisphthalocyanine complexes using microwave irradiation

  摘要：

  Starting with phthalic and 4-tert-butylphthalic acid derivatives, the bisphthalocyanines of rare earth elements and hafnium and zirconium were prepared using microwave irradiation.

  DOI：

  10.1070/mc2002v012n02abeh001558

文献信息

• Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
  申请人：——

  公开号：US20020082292A1

  公开（公告）日：2002-06-27

  A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.

  苯并吡喃羧酸衍生物类别包括强效PPARα和/或γ激动剂化合物，因此在治疗、控制或预防非胰岛素依赖型糖尿病（NIDDM）、高血糖、血脂异常、高血脂症、高胆固醇血症、高甘油三酯血症、动脉粥样硬化、肥胖、血管再狭窄、炎症和其他PPARα和/或γ介导的疾病、紊乱和状况中具有用处。
• Pyridine derivatives and their compositions for the control of insect
  申请人：——

  公开号：US05151428A1

  公开（公告）日：1992-09-29

  A pyridine derivative of the formula: ##STR1## wherein R.sup.1 is, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 haloalkyl group, a C.sub.1 -C.sub.3 alkoxy gorup, a C.sub.1 -C.sub.3 haloalkoxy group, a cyano group or a nitro group; R.sup.2 is, the same or different, each a hydrogen atom, a halogen atom or a methyl group; R.sup.3 is a halogen atom or a C.sub.1 -C.sub.3 alkyl group; R.sub.4 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; R.sup.5 is, the same or different, each a halogen atom, a C.sub.1 -C.sub.3 alkyl group, a C.sub.1 -C.sub.3 haloalkyl group, a C.sub.1 -C.sub.3 alkoxy group or a C.sub.1 -C.sub.3 haloalkoxy group; X is an oxygen atom, a sulfur atom, a carbonyl group, a sulfinyl group, a sulfonyl group, an imino group or a methylene group; Y is an oxygen atom or a sulfur atom; l is an integer of 1 to 5; m is an integer of 1 to 3; and n is an integer of 1 to 4, which is useful for control of insect pest.

  一种吡啶衍生物，其化学式为：##STR1## 其中R.sup.1是氢原子，卤素原子，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4卤代烷基，C.sub.1-C.sub.3烷氧基，C.sub.1-C.sub.3卤代烷氧基，氰基或硝基，可以相同或不同；R.sup.2是氢原子，卤素原子或甲基，可以相同或不同；R.sup.3是卤素原子或C.sub.1-C.sub.3烷基；R.sub.4是氢原子或C.sub.1-C.sub.3烷基；R.sup.5是氢原子，卤素原子，C.sub.1-C.sub.3烷基，C.sub.1-C.sub.3卤代烷基，C.sub.1-C.sub.3烷氧基或C.sub.1-C.sub.3卤代烷氧基，可以相同或不同；X是氧原子，硫原子，羰基，烷基硫醇基，烷基磺酰基，亚胺基或亚甲基基；Y是氧原子或硫原子；l是1到5的整数；m是1到3的整数；n是1到4的整数。该化合物对于控制昆虫害虫具有益处。
• Dioxolane derivatives
  申请人：Ciba-Geiby Corporation

  公开号：US05663453A1

  公开（公告）日：1997-09-02

  Compounds of the formula ##STR1## in which: n is 0, 1 or 2, and, if n is 2, the two radicals R.sub.3 are identical or different; R.sub.2 is methyl, fluorine, chlorine or bromine; R.sub.3 is C.sub.1 -C.sub.3 -alkyl, halo-C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halo-C.sub.1 -C.sub.3 alkoxy, fluorine, chlorine or bromine: R.sub.5 is hydrogen or C.sub.1 -C.sub.9 alkyl and X is methylene, O, S or C(.dbd.O): can be used as intermediates for agrochemical active ingredients.

  式为##STR1##的化合物，其中：n为0、1或2，若n为2，则两个基团R.sub.3相同或不同；R.sub.2为甲基、氟、氯或溴；R.sub.3为C.sub.1-C.sub.3-烷基、卤代C.sub.1-C.sub.3-烷基、C.sub.1-C.sub.3-烷氧基、卤代C.sub.1-C.sub.3-烷氧基、氟、氯或溴；R.sub.5为氢或C.sub.1-C.sub.9-烷基，X为亚甲基、氧、硫或C(.dbd.O)：可用作农药活性成分的中间体。
• Pyridine derivatives, their production processes and their compositions
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05243087A1

  公开（公告）日：1993-09-07

  A pyridine derivative of the formula: ##STR1## wherein R.sup.1 is, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 haloalkyl group, a C.sub.1 -C.sub.3 alkoxy group, a C.sub.1 -C.sub.3 haloalkoxy group, a cyano group or a nitro group; R.sup.2 is, the same or different, each a hydrogen atom, a halogen atom or a methyl group; R.sup.3 is a halogen atom or a C.sub.1 -C.sub.3 alkyl group; R.sup.4 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; R.sup.5 is, the same or different, each a halogen atom, a C.sub.1 -C.sub.3 alkyl group, a C.sub.1 -C.sub.3 haloalkyl group, a C.sub.1 -C.sub.3 alkoxy group or a C.sub.1 -C.sub.3 haloalkoxy group; X is an oxygen atom, a sulfur atom, a carbonyl group, a sulfinyl group, a sulfonyl group, an imino group or a methylene group; Y is an oxygen atom or a sulfur atom; l is an integer of 1 to 5; m is an integer of 1 to 3; and n is an integer of 1 to 4, which is useful for control of insect pest.

  一种吡啶衍生物，其化学式为：##STR1## 其中R.sup.1，相同或不同，每个是氢原子、卤素原子、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4卤代烷基、C.sub.1-C.sub.3烷氧基、C.sub.1-C.sub.3卤代烷氧基、氰基或硝基；R.sup.2，相同或不同，每个是氢原子、卤素原子或甲基基团；R.sup.3是卤素原子或C.sub.1-C.sub.3烷基；R.sup.4是氢原子或C.sub.1-C.sub.3烷基；R.sup.5，相同或不同，每个是卤素原子、C.sub.1-C.sub.3烷基、C.sub.1-C.sub.3卤代烷基、C.sub.1-C.sub.3烷氧基或C.sub.1-C.sub.3卤代烷氧基；X是氧原子、硫原子、羰基、亚磺酰基、磺酰基、亚胺基或亚甲基基团；Y是氧原子或硫原子；l是1到5的整数；m是1到3的整数；n是1到4的整数，该化合物对昆虫害虫的控制具有用途。
• Procédé de préparation de phénols métachlorés
  申请人：RHONE-POULENC SPECIALITES CHIMIQUES

  公开号：EP0055196A1

  公开（公告）日：1982-06-30

  Procédé de préparation de phénols métachlorés à partir de polychlorophénols comportant des atomes de chlore à la fois en position méta et ortho et/ou para par déchloration sélective par hydrogénation en phase aqueuse acide contenant des ions halogénures et en présence d'un catalyseur à base d'un métal noble. Les phénols métachlorés sont utilisés comme intermédiaires en synthèse organique.

  在含有卤化离子的酸性水相中，在以贵金属为基础的催化剂存在下，通过氢化选择性脱氯，从在元位、正位和/或对位均含有氯原子的多氯酚制备偏氯苯酚的工艺。 偏氯苯酚可用作有机合成的中间体。