N-(2-methylbenzyl)ethylenediamine | 622373-91-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methylbenzyl)ethylenediamine
• 英文别名: N¹-(2-methylbenzyl)ethane-1,2-diamine；N-(2-aminoethyl)-N-(2-methylbenzyl)amine；N'-[(2-methylphenyl)methyl]ethane-1,2-diamine
• CAS: 622373-91-5
• 化学式: C₁₀H₁₆N₂
• mdl: MFCD04357832
• 分子量: 164.25
• InChiKey: WJKMFHVWDDNEQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2921590090

反应信息

• 作为反应物：
  描述：

  N-(2-methylbenzyl)ethylenediamine 在 sodium methylate 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 8.0h， 生成 7-(4-fluorobenzyl)-3-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
  参考文献：
  名称：

  Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo

  摘要：

  DOI：

  10.1021/acs.jmedchem.1c02071
• 作为产物：
  描述：

  乙二胺 、 2-甲基苯甲醛 在 sodium tetrahydroborate 作用下， 以 甲苯 、 乙醇 为溶剂， 反应 9.0h， 以23%的产率得到N-(2-methylbenzyl)ethylenediamine
  参考文献：
  名称：

  新型取代萘二酰亚胺作为抗癌剂的构效关系

  摘要：

  合成了新型的1,4,5,8-萘四甲酸二酰亚胺（NDI）衍生物，并评估了它们在多种不同肿瘤细胞系中的抗增殖活性。本系列的原型是衍生物1和2，其特征在于有趣的生物学特性作为抗癌剂。本研究扩展了原型1和原型2的结构与活性关系的研究，即苯环的不同取代基对生物活性的影响。衍生工具3 – 22以芳香环上不同的取代基和/或从两个碳原子单元到三个碳原子单元的不同链长为特征的α，β-环糊精被合成，并对其细胞抑制活性和细胞毒性活性进行了评估。最有趣的化合物是20，其特征在于三个亚甲基单元和两个芳环上的2,3,4-三甲氧基取代基的连接基。它显示出在亚微摩尔范围内的抗增殖活性，尤其是针对某些不同的细胞系，具有抑制Taq聚合酶和端粒酶，通过可能的氧化机制触发caspase活化，下调ERK 2蛋白和抑制ERKs磷酸化的能力，而没有直接作用于微管和微管。它对双链和四链DNA结构的理论认识已与实验热力学测量结果进行了比较

  DOI：

  10.1016/j.ejmech.2012.06.045

文献信息

• Design, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues
  作者：Xiao Zhang、Yiping Wang、Zhiping Xu、Xusheng Shao、Zewen Liu、Xiaoyong Xu、Peter Maienfisch、Zhong Li

  DOI：10.1021/acs.jafc.0c04786

  日期：2021.3.17

  cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogues of IPPA08 by converting the pyridyl moiety of IPPA08 into phenyl groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found

  由于杀虫剂增效剂具有通过减少剂量的活性成分来提高杀虫剂控制功效的潜力，因此受到人们的追捧。我们先前曾报道，顺式构型的新烟碱类（IPPA08）对新烟碱类杀虫剂表现出特定的协同活性。在这项研究中，我们通过硝基亚甲基化合物与戊二醛之间的便捷双曼尼希缩合反应，将IPPA08的吡啶基部分转化为苯基，从而合成了IPPA08的一系列结构类似物。发现所有的羰桥新烟碱类化合物均可增强吡虫啉对蚜虫的毒性。值得注意的是，浓度为0.75 mg / L的化合物25降低了吡虫啉对Cr。craccivora的LC 50值IPPA08的LC 50值降低了6.54倍，而LC 50值降低了3.50倍。蜂毒性试验的结果表明，化合物25关于对蜜蜂吡虫啉毒性（在它的影响显示选择性蜜蜂L.）。总之，用苯环取代吡啶环是获得新烟碱类杀虫剂具有氧桥缩合部分的新型增效剂的可行方法。
• Crosslinkers for improving stability of polyurethane foams
  申请人：Vedage Gamini Ananda

  公开号：US20080090922A1

  公开（公告）日：2008-04-17

  A composition for making a polyurethane foam includes a non-fugitive tertiary amine urethane catalyst and an alkylated polyamine crosslinking additives. Foams prepared from the reaction of a polyol and an organic isocyanate in the presence of these ingredients show improved resistance to deterioration of physical properties upon humid aging.

  一种制备聚氨酯泡沫的配方包括非挥发性三级胺脲催化剂和烷基化聚胺交联添加剂。在这些成分的存在下，聚醚和有机异氰酸酯反应制备的泡沫在湿度老化时显示出改善的物理性能耐久性。
• Design, Synthesis, and Synergistic Activities of Eight‐Membered Carbon Bridged Neonicotinoid Derivatives
  作者：Du Tan、Xiaoyong Xu、Zhong Li、Zhiping Xu、Xusheng Shao

  DOI：10.1002/cbdv.202301412

  日期：2024.2

  Insecticide synergists are an effective approach to increase the control efficacy and reduce active ingredient usage. In order to explore neonicotinoid-specific synergists with novel scaffolds and higher potency, a series of eight-membered carbon bridged neonicotinoid derivatives were designed and synthesized in accordance with our previous research. The synergistic effects of the target compounds

  杀虫增效剂是提高防治效果和减少活性成分使用量的有效方法。为了探索具有新颖支架和更高效力的新烟碱类特异性增效剂，根据我们前期的研究，设计并合成了一系列八元碳桥新烟碱类衍生物。评价了目标化合物对蚜虫新烟碱类杀虫剂的协同作用，并总结了构效关系。结果表明，大多数目标化合物在低浓度下对羊螈中的吡虫啉表现出显着的协同作用。特别地，浓度为1mg/L的化合物1将吡虫啉的LC 50值从0.856mg/L降低至0.170mg/L。同时，化合物1还提高了属于杀虫剂抗性行动委员会 (IRAC) 4 A 亚组的大多数新烟碱类杀虫剂对A. craccivora 的杀虫活性。本研究对于指导新烟碱类特异性增效剂的设计可能有意义。
• Encapsulation
  申请人：The Procter & Gamble Company

  公开号：US10864167B2

  公开（公告）日：2020-12-15

  An improved process of making a benefit agent delivery particle and consumer products incorporating such particles are disclosed. The process comprises the steps of providing a first composition of water phase 1, water phase 2 and water phase 3. Water phase 1 comprises water and an initiator; water phase 2 comprises water, a water-soluble or dispersible amine(meth)acrylate or hydroxyl(meth)acrylate and a multifunctional (meth)acrylate. Water phase 3 comprises water, and carboxyalkyl(meth)acrylate and a base or quaternary ammonium acrylate. The first two water phases are combined to prereact the hydroxy- or amine(meth)acrylate and the multifunctional (meth)acrylate to form a multifunctional hydroxyl-amine(meth)acrylate pre-polymer. The pre-polymer is combined with water phase 3; then an emulsion is formed by emulsifying under high shear agitation a second composition into said first composition; said second composition comprising an oil phase comprising an isocyanate and a benefit agent core material thereby forming a wall surrounding the benefit agent core material.

  本发明公开了一种改进的益处剂输送颗粒制造工艺和含有这种颗粒的消费品。该工艺包括以下步骤：提供由水相 1、水相 2 和水相 3 组成的第一种组合物。水相 1 由水和引发剂组成；水相 2 由水、水溶性或分散性甲基丙烯酸胺或甲基丙烯酸羟基酯和多功能（甲基）丙烯酸酯组成。水相 3 包括水、羧基烷基（甲基）丙烯酸酯和碱或丙烯酸季铵。将前两相水合并，使羟基或胺（甲基）丙烯酸酯和多功能（甲基）丙烯酸酯发生预反应，形成多功能羟基-胺（甲基）丙烯酸酯预聚物。将预聚物与水相 3 结合；然后在高剪切搅拌下将第二种组合物乳化到所述第一种组合物中，形成乳液；所述第二种组合物包括由异氰酸酯组成的油相和益处剂芯材，从而形成围绕益处剂芯材的壁。
• Binding activity of substituted benzyl derivatives of chloronicotinyl insecticides to housefly-head membranes, and its relationship to insecticidal activity against the houseflyMusca domestica
  作者：Hisashi Nishiwaki、Yoshiaki Nakagawa、David Y Takeda、Atsushi Okazawa、Miki Akamatsu、Hisashi Miyagawa、Tamio Ueno、Keiichiro Nishimura

  DOI：10.1002/1526-4998(200010)56:10<875::aid-ps220>3.0.co;2-a

  日期：2000.10

  Variously substituted benzyl derivatives of chloronicotinyl insecticides were synthesized with a wide range of substituents including halogens, NO2, CN, CF, and small alkyl and alkoxy groups at the ortho, meta and para positions, as well as multiple-substituted benzyl analogues. Their binding activity to the alpha-bungarotoxin binding site in housefly (Musca domestica) head membrane preparations was measured. Among the compounds tested, the activity of the meta-CN derivative was the highest, being 20-100 times higher than those of imidacloprid, acetamiprid and nitenpyram. The synergized insecticidal activity against houseflies was also measured for selected compounds with the metabolic inhibitor, NIA16388 (propargyl propyl phenylphosphonate). For the nitromethylene analogues, including both benzyl and pyridylmethyl analogues, higher binding activity usually resulted in higher insecticidal activity. (C) 2000 Society of Chemical Industry.