(2-chlorophenyl)-(2,4,6-trimethylphenyl)methanone | 71783-50-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-chlorophenyl)-(2,4,6-trimethylphenyl)methanone
• 英文别名: 2-chloro-2',4',6'-trimethylbenzophenone；2'-Chloro-2,4,6-trimethylbenzophenone；2,4,6-trimethylbenzophenone；2'-chloro-2,4,6-trimethyl-benzophenone；2'-Chlor-2,4,6-trimethyl-benzophenon；2-Chlor-2',4',6'-trimethyl-benzophenon；(2-Chlorophenyl)(2,4,6-trimethylphenyl)methanone
• CAS: 71783-50-1
• 化学式: C₁₆H₁₅ClO
• mdl: MFCD01850971
• 分子量: 258.748
• InChiKey: FKMWZVIVMLJAEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.187
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  邻氯苯甲酰氯 、 均三甲苯 在 三氯化铝 作用下， 以 various solvent(s) 为溶剂， 反应 5.0h， 生成 (2-chlorophenyl)-(2,4,6-trimethylphenyl)methanone
  参考文献：
  名称：

  通过克尔效应和偶极矩方法研究二苯甲酮的构象

  摘要：

  摘要 报告了不同取代的二苯甲酮（例如 (4-FC 6 H 4 ) 2 CO、(4-ClC 6 H 4 )(C 6 H 5 )CO、(4-MeC 6 H 4 )(C 6 H 5 )CO、(4-MeOC 6 H 4 )(C 6 H 5 )CO、(2-ClC 6 H 4 )(C 6 H 5 )CO、(2-MeC 6 H 4 ) (C 6 H 5 )CO, (4-ClC 6 H 4 )(2',4',6'-Me 3 C 6 H 2 )CO, (2-ClC 6 H 4 )(2',4', 6'-Me 3 C 6 H 2 )CO 和 (C 4 H 3 S)(4'-MeOC 6 H 4 )CO) 作为溶质在 298 K 的二恶烷溶液中。根据优选构象分析数据解决方案中采用。在大多数情况下，这些数据与不对称 (gauche) 构象异构体在二恶烷中的存在一致，即两个芳环相对于 C Ar -C(0)-C Ar 分子

  DOI：

  10.1016/0022-2860(94)08360-6

文献信息

• Erbium trifluoromethanesulfonate catalyzed Friedel–Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation
  作者：Phuong Hoang Tran、Poul Erik Hansen、Hai Truong Nguyen、Thach Ngoc Le

  DOI：10.1016/j.tetlet.2014.12.038

  日期：2015.1

  Erbium trifluoromethanesulfonate is found to be a good catalyst for the Friedel–Crafts acylation of arenes containing electron-donating substituents using aromatic carboxylic acids as the acylating agents under microwave irradiation. An effective, rapid and waste-free method allows the preparation of a wide range of aryl ketones in good yields and in short reaction times with minimum amounts of waste

  发现三氟甲烷磺酸b是在微波辐射下，使用芳族羧酸作为酰化剂，对含给电子取代基的芳烃进行弗瑞德-克拉夫茨酰化的良好催化剂。一种有效，快速且无浪费的方法可以在不浪费最少的情况下以良好的收率和较短的反应时间制备各种芳基酮。
• Tunable Aryl Imidazolium Recyclable Ionic Liquid with Dual Brønsted–Lewis Acid as Green Catalyst for Friedel–Crafts Acylation and Thioesterification
  作者：Yi-Jyun Lin、Yao-Peng Wu、Mayur Thul、Ming-Wei Hung、Shih-Huan Chou、Wen-Tin Chen、Wesley Lin、Michelle Lin、Daggula Mallikarjuna Reddy、Hsin-Ru Wu、Wen-Yueh Ho、Shun-Yuan Luo

  DOI：10.3390/molecules25020352

  日期：——

  Unique tunable aryl imidazolium ionic liquids successfully catalyzed Friedel–Crafts acylation and thioesterification in sealed tubes. These reactions can form a C−C bond and a C−S bond with high atom economy. Ionic liquids exhibited high activity and catalyzed essential reactions with good to excellent yields while retaining their catalytic activities for recycling.

  独特可调节的芳基咪唑离子液体成功地催化了密封管中的Friedel-Crafts酰化和硫酯化反应。这些反应可以以高原子经济性形成C−C键和C−S键。离子液体表现出高活性，催化了必要的反应，产率良好至优良，同时保持其催化活性以进行循环利用。
• Remarkably stable ortho-halophenylcopper reagents
  作者：Greg W. Ebert、Deborah R. Pfennig、Scott D. Suchan、Thomas A. Donovan

  DOI：10.1016/s0040-4039(00)77593-9

  日期：1993.4

  We wish to report the generation of remarkably stable o-halophenlycopper reagents at room temperature by the direct oxidative addition of activated copper to o-flouro-and o-choloriodobenzene. The reagents will undergo substitution reactions with suitable organic halides at 25°C.

  我们希望报告在室温下通过将氧化活性铜直接氧化成邻氟和邻氯代邻苯二甲生成稳定的邻卤代铜试剂。试剂将在25°C与合适的有机卤化物进行取代反应。
• The Behavior of 3-Chlorophthalic Anhydride in Friedel-Crafts and Grignard Condensations
  作者：Melvin S. Newman、Paul G. Scheurer

  DOI：10.1021/ja01600a054

  日期：1956.10
• Direct Formation of (Haloaryl)copper Nucleophiles from Haloiodobenzenes and Active Copper
  作者：Greg W. Ebert、Deborah R. Pfennig、Scott D. Suchan、Thomas A. Donovan、Emmanuel Aouad、Safa S. Tehrani、James N. Gunnersen、Liming Dong

  DOI：10.1021/jo00113a013

  日期：1995.4

  (o-Halophenyl)-; (m-halophenyl)-, and (p-halophenyl)copper reagents have been formed in moderate to high yields at room temperature from active copper and the corresponding haloiodobenzenes. These reagents have been cross-coupled with a variety of alkyl and acyl halides to produce the respective haloarenes and haloaryl ketones. Remarkably, (o-fluorophenyl)- and (o-chlorophenyl)copper are produced in good yields by this procedure without undergoing elimination to form benzyne making this approach a convenient method for generating o-halophenyl nucleophiles.