N,N’-(1-butylene)dibenzamide | 157944-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N’-(1-butylene)dibenzamide
• 英文别名: N,N'-(n-propylmethylene)dibenzamide；N-(1-benzamidobutyl)benzamide
• CAS: 157944-93-9
• 化学式: C₁₈H₂₀N₂O₂
• 分子量: 296.369
• InChiKey: BNPOLFURWHJCSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲酰胺 、 正丁醛 在 1-己炔 作用下， 反应 0.17h， 以76%的产率得到N,N’-(1-butylene)dibenzamide
  参考文献：
  名称：

  Silica-supported barium chloride (SiO₂–BaCl₂) — Efficient and heterogeneous catalyst for the environmentally friendly preparation of N,N′-alkylidene bisamides under solvent-free conditions

  摘要：

  一系列N,N'-烷基亚胺双酰胺通过绿色环保的合成方法制备而成，其反应物为苯乙炔或己-1-炔、芳香醛和苯甲酰胺或乙酰胺。硅胶负载的氯化钡（SiO₂-BaCl₂）催化反应过程。所制备的催化剂经过X射线衍射表征，产物的转化率和收率均较高。

  DOI：

  10.1139/v11-007

文献信息

• ONE POT PREPARATIONS N,N'-ALKYLIDENE BISAMIDE DERIVATIVES CATALYZED BY NANO-TiCL4.SiO2 WITH ANTIMICROBIAL STUDIES OF SOME PRODUCTS
  作者：SOGHRA KHABNADIDEH、KAMIAR ZOMORODIAN、BI BI FATEMEH MIRJALILI、ELHAM IZADI、LEILA ZAMANI

  DOI：10.4067/s0717-97072016000300005

  日期：——

  2 has been introduced to be an extremely efficient catalyst for the preparation of N,N’ -alkylidene bisamides from various aldehydes and amides under mild conditions. We synthesized this solid Lewis acid catalyst by the reaction of nano-SiO 2 and TiCl 4 . The processor was simple and environmentally benign with high to excellent yields. Our method has the advantages of high yields, simple methodology

  摘要纳米TiCl 4 .SiO 2是一种非常有效的催化剂，用于在温和条件下由各种醛和酰胺制备N，N'-亚烷基双酰胺。我们通过纳米SiO 2和TiCl 4的反应合成了这种固体路易斯酸催化剂。该处理器简单易用，对环境无害，良率极高。我们的方法的优点是产量高，方法简单，后处理容易。根据临床实验室标准协会的建议，通过肉汤微量稀释法确定某些合成化合物的抗微生物和抗真菌活性。关键词：纳米-TiCl 4 .SiO 2，非均相催化剂，N，N'-亚烷基双酰胺，抗真菌，抗菌。电子邮件：
• Tandem synthesis of N,N′-alkylidenebisamides promoted by nano-SnCl4.SiO2
  作者：BIBI FATEMEH MIRJALILI、MOHAMMAD ALI MIRHOSEINI

  DOI：10.1007/s12039-013-0519-2

  日期：2013.11

  A highly efficient procedure for the preparation of N,N ′-alkylidenebisamides in the presence of nano-SnCl4.SiO2 as a catalysis described. N,N ′-alkylidenebisamides have been prepared via condensation reaction of various aldehydes and amides. All of the reactions proceeded in high yields and in moderately short reaction times.

  描述了一种高效的制备N,N' -烯丙基双酰胺的程序，该过程在纳米SnCl4.SiO2催化剂的存在下进行。N,N' -烯丙基双酰胺是通过各种醛和酰胺的缩合反应制备的。所有反应均以高产率和适中的短反应时间进行。
• One-Pot Preparation of N,N'-Alkylidene Bisamide Derivatives Catalyzed by Silica Supported Magnesium Chloride (SiO2-MgCl2)
  作者：Mohammad R.M. Shafiee

  DOI：10.2174/157017811797249344

  日期：2011.10.1

  A highly efficient and simple procedure for the preparation of N,N'-alkylidene bisamides via one-pot threecomponent condensation reaction of phenyl acetylene/1-Hexyne, aromatic aldehyde and benzamide/acetamide in the presence of catalytic amount of silica supported magnesium chloride (SiO2-MgCl2) under thermal solvent-free conditions is described. All of the reactions proceeded in high yields and in relatively short reaction times.

  介绍了在热无溶剂条件下，在二氧化硅支撑的氯化镁（SiO2-MgCl2）催化下，通过苯乙炔/1-己炔、芳香醛和苯甲酰胺/乙酰胺的一锅三组份缩合反应制备 N,N'-亚烷基双酰胺的高效而简单的过程。所有反应的产率都很高，反应时间也相对较短。
• Mild, efficient, and environmentally friendly synthesis of symmetrical N,N′-alkylidenebisamides under solvent-free conditions catalyzed by H₇[(P₂W₁₇O₆₁)Fe^III(H₂O)]
  作者：R. Tayebee、B. Maleki、F. M. Zonoz、R. M. Kakhki、T. Kunani

  DOI：10.1039/c6ra01811d

  日期：——

  synthesized via a one-pot three-component green and environmentally friendly condensation of aliphatic and/or aromatic aldehydes with benzamide by the mediation of 2.5 mol% H7[(P2W17O61)FeIII(H2O)] as a Lewis/Bronsted acid catalyst with good to excellent yields in moderately short reaction times. This developed methodology is effective for diverse substituted aldehydes; thus, it constitutes a general synthetic

  一系列的对称Ñ，Ñ '-alkylidenebisamides成功地合成通过与苯甲酰胺的脂族和/或芳族醛的一锅三组分绿色环保缩合的2.5摩尔％H调解7 [（P 2 w ^ 17 O 61）Fe III（H 2 O）]，路易斯/布朗斯台德酸催化剂，在短短的反应时间内具有良好或优异的收率。这种发达的方法对于各种取代的醛均有效。因此，它构成了制备对称亚烷基双酰胺的一般合成途径。研究结果表明，含有吸电子基团的芳香醛比其给电子对应的醛更有效。
• Silica-supported barium chloride (SiO₂–BaCl₂) — Efficient and heterogeneous catalyst for the environmentally friendly preparation of <i>N</i>,<i>N</i>′-alkylidene bisamides under solvent-free conditions
  作者：Mohammad Reza Mohammad Shafiee

  DOI：10.1139/v11-007

  日期：2011.5

  A series of N,N′-alkylidene bisamides were prepared via a green and environmentally friendly synthetic protocol from the reaction of phenyl acetylene or hex-1-yne, aromatic aldehyde, and benzamide or acetamide. Silica-supported barium chloride (SiO₂–BaCl₂) catalyzes the process of the reaction. The prepared catalysts were characterized by X-ray diffraction, and the products were obtained with high conversions and yields.

  一系列N,N'-烷基亚胺双酰胺通过绿色环保的合成方法制备而成，其反应物为苯乙炔或己-1-炔、芳香醛和苯甲酰胺或乙酰胺。硅胶负载的氯化钡（SiO₂-BaCl₂）催化反应过程。所制备的催化剂经过X射线衍射表征，产物的转化率和收率均较高。