terephthalic acid monoisopropyl ester | 20576-81-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: terephthalic acid monoisopropyl ester
• 英文别名: Terephthalsaeure-monoisopropylester；Terephthalisopropylestersaeure；4-[(Propan-2-yloxy)carbonyl]benzoic acid；4-propan-2-yloxycarbonylbenzoic acid
• CAS: 20576-81-2
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: RIEGOSCYEGIECP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  terephthalic acid monoisopropyl ester 在 palladium dichloride 异喹啉 、 三乙胺 、 lithium chloride 作用下， 以 二氯甲烷 为溶剂， 生成 4-(1-Phenyl-vinyl)-benzoic acid isopropyl ester
  参考文献：
  名称：

  Pd-Catalyzed Decarbonylative Olefination of Aryl Esters: Towards a Waste-Free Heck Reaction

  摘要：

  DOI：

  10.1002/1521-3773(20020402)41:7<1237::aid-anie1237>3.0.co;2-f
• 作为产物：
  描述：

  丙-2-基4-甲基苯甲酸酯 在 air 、 chromium-salts 作用下， 生成 terephthalic acid monoisopropyl ester
  参考文献：
  名称：

  Kobayashi et al., Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1956, vol. 59, p. 449,453

  摘要：

  DOI：

文献信息

• Ionic liquids as solvent for efficient esterification of carboxylic acids with alkyl halides
  作者：YETKİN GÖK、BÜLENT ALICI、ENGİN ÇETİNKAYA、İSMAİL ÖZDEMİR、ÖZLEM ÖZEROĞLU

  DOI：10.3906/kim-0904-39

  日期：——

  The selective esterification of carboxylic acid derivatives with a variety of alkyl halides was carried out using ionic liquid as solvent in the presence of triethylamine. The reaction was found to proceed under relatively mild conditions with excellent conversions (up to 99%) and selectivities. The ionic liquid was recycled and reused.

  选择性酯化羧酸衍生物与多种烷基卤化物在三乙胺存在下使用离子液体作为溶剂进行。该反应在相对温和的条件下进行，具有极佳的转化率（高达99%）和选择性。离子液体可以回收并重复使用。
• MEXILETINE PRODRUGS
  申请人：Franklin Richard

  公开号：US20120196933A1

  公开（公告）日：2012-08-02

  The present invention concerns prodrugs of mexiletine (and mexiletine's active metabolite) pharmaceutical compositions containing such prodrugs. Methods for treating myotonic conditions, while reducing the inherent adverse GI side effects associated with mexiletine, increasing the bioavailability of mexiletine, and improving the pharmacokinetic reproducibility of mexiletine with the aforementioned prodrugs are also provided.

  本发明涉及美西律定（以及美西律定的活性代谢物）的前药以及含有这些前药的药物组合物。还提供了治疗肌张力不良症的方法，同时减少与美西律定相关的固有不良胃肠副作用，增加美西律定的生物利用度，并改善美西律定的药代动力学可重复性。
• Process for producing butene-1 polymer
  申请人：IDEMITSU PETROCHEMICAL CO. LTD.

  公开号：EP0249984A2

  公开（公告）日：1987-12-23

  This invention provides a process for producing a butene-1 polymer in the presence of a catalyst obtained from a solid catalyst component (A) prepared from a magnesium compound, an electron donating compound and a titanium compound, an organoaluminum compound (B) and an electron donating compound (C), said electron donating compound (C) being at least one compound selected from the group consisting of organophosphorus compound of the following general formula(1) and heterocyclic compound of the follwoing qeneral formula(2): . (wherein R1 and R2 each represents an alkyl, cycloalkyl or aryl group of 1-10 carbon atoms, X represents a halogen atom and m and n are real numbers which satisfy 0

  本发明提供了一种在催化剂存在下生产丁烯-1聚合物的工艺，催化剂由镁化合物、电子供体化合物和钛化合物制备的固体催化剂组分(A)、有机铝化合物(B)和电子供体化合物(C)组成，所述电子供体化合物(C)是至少一种选自以下通式(1)的有机磷化合物和以下通式(2)的杂环化合物组成的化合物： .(其中 R1 和 R2 分别代表 1-10 个碳原子的烷基、环烷基或芳基，X 代表卤素原子，m 和 n 是实数，满足 0
• Polyetherimide-liquid crystal polymer blends
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0278066A2

  公开（公告）日：1988-08-17

  Disclosed are blends of (a) a polyetherimide and (b) a liquid crystal polymer. The liquid crystal polymer is an aromatic copolyester which exhibits melt anisotropy. The blends exhibit a higher heat distortion temperature higher flexural modulus and specific gravity over the polyetherimide component alone and have a higher tensile strength than that associated with the liquid crystal polymer alone.

  公开了 (a) 聚醚酰亚胺和 (b) 液晶聚合物的混合物。液晶聚合物是一种芳香族共聚聚酯，具有熔体各向异性。与单独的聚醚酰亚胺成分相比，混合物具有更高的热变形温度、更高的弯曲模量和比重，其拉伸强度也高于单独的液晶聚合物。
• Process for producing polybutene-1
  申请人：IDEMITSU PETROCHEMICAL CO. LTD.

  公开号：EP0294767A1

  公开（公告）日：1988-12-14

  Disclosed is a process for producing polybutene-1 suitable to be molded into pipes and the like by vapor phase polymerization in the presence of a catalyst obtained from (A) a solid catalyst component obtained from a magnesium compound, an electron donating compound and a halide of tetravalent titanium (B) an organoaluminum compound and (C) an electron donor wherein said solid catalyst component (A) has an average particle size of 5-200µm, a geometrical standard deviation (σ g) of particle size distribution of less than 2.1 and a molar ratio of electron donating compound/magnesium of 0.01 or more and said electron donor (C) is at least one compound selected from the group consisting of a heterocyclic compound represented by the formula: (wherein R¹, R², R³, R⁴ and R⁵ are as defined before), an ether compound represented by the formula:     R6nC(OR⁷)4-n      (2) (wherein R⁶ and R⁷ and n are as defined before) and an organic peroxide represented by the formula: (wherein R⁸, R⁹, R¹⁰ and R¹¹ are as defined), and the vapor phase polymerization is carried out at a molar ratio of hydrogen/butene-1 of 0.001-0.1.

  本发明公开了一种通过气相聚合生产聚丁烯-1 的工艺，该聚丁烯-1 适合在以下催化剂的存在下模塑成管道或类似物：(A) 由镁化合物、电子供体化合物和四价钛的卤化物组成的固体催化剂组分 (B) 有机铝化合物和 (C) 电子供体，其中所述固体催化剂组分 (A) 的平均粒径为 5-200µm，粒径分布的几何标准偏差 (σg)小于 2.1 且电子供体化合物/镁的摩尔比为 0.01 或更高，且所述电子供体 (C) 至少是一种选自以下组别的化合物：由式表示的杂环化合物： (其中 R¹、R²、R³、R⁴ 和 R⁵ 如前定义）、 由以下式子表示的醚化合物 R6nC(OR⁷)4-n (2) (其中 R⁶、R⁷ 和 n 如前定义）和由式表示的有机过氧化物： (其中 R⁸、R⁹、R¹⁰ 和 R¹¹ 如前定义），以及 气相聚合在氢/丁烯-1 的摩尔比为 0.001-0.1 的条件下进行。