Selenium-cystine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Selenium-cystine
• 化学式: C3H6NO2Se
• 分子量: 167.06
• InChiKey: FDKWRPBBCBCIGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.01
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

ADMET

毒理性

• 相互作用

镉、汞（Hg）和三种不同化学形式的硒（亚硒酸盐、硒代胱氨酸和硒代蛋氨酸）对公羊精子运动能力和体外耗氧量的影响进行了为期4个月的研究。浓度为10(-6)至10(-2) M的镉和汞对精子有害，表现为运动能力下降和耗氧量减少。等摩尔浓度的亚硒酸盐、硒代胱氨酸或硒代蛋氨酸能抵消低浓度（10(-5)和10(-6) M）镉和汞的毒性，但在较高浓度（10(-4)至10(-2) M）时则不能。/硒代胱氨酸/

The effects of cadmium, mercury (Hg), and three different chemicals forms of selenium (selenite, selenocystine, and selenomethionine) on ram spermatozoal motility and oxygen consumption in vitro were studied over a 4 mo period. Concentrations of 10(-6) to 10(-2) M cadmium and mercury were injurious to spermatozoa as indicated by depressed motility and reduced oxygen uptake. Equimolar concentrations of selenium as selenite, selenocystine, or selenomethionine counteracted the toxicity of cadmium and mercury at low concentrations (10(-5) and 10(-6) M) but not at higher concentrations (10(-4) to 10(-2) M). /Selenocystine/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

亚硒酸盐、硒化物、二氧化硒、硒代甲硫氨酸和硒胱氨酸在大鼠7,12-二甲基苯并(a)蒽诱导乳腺癌模型中的致癌促进阶段的化学预防效果进行了检测。每种试剂以最终浓度为3 ppm的硒添加到饮食中。总的来说，这五种硒化合物在抑制乳腺肿瘤发展方面的效力没有显著差异。在第二个致癌研究中进一步表征了维生素E（500 ppm）与硒化物或硒代甲硫氨酸的相互作用。实验结果表明，维生素E增强了硒化物的保护作用，但并未增强硒代甲硫氨酸的。为了探索硒和维生素E的协同机制，还研究了这两种试剂对有丝分裂原诱导的细胞增殖和自然杀伤细胞毒活性的影响。在体外免疫功能的检测中，并未发现超营养喂养硒化物或维生素E或两者都有时会导致这些功能的一致性变化。... /胱氨酸/

The chemopreventive efficacies of selenate, selenite, selenium dioxide, selenomethionine and selenocystine were examined during the promotion phase of carcinogenesis in the 7,12-dimethylbenz(a)anthracene-induced mammary tumor model in rats. Each agent was added to the diet of a final concentration of 3 ppm selenium. In general, there was no significant difference in the potency of these five selenium compounds in inhibiting the development of mammary tumors. The interaction of vitamin E (500 ppm) with either selenite or selenomethionine was further characterized in a second carcinogenesis study. Results of this experiment suggested that vitamin E enhanced the protective effect of selenite but not that of selenomethionine. In an attempt to explore the synergistic mechanism of selenium and vitamin E, the effects of these two agents on mitogen induced blastogenesis and natural killer cytotoxic activity were also investigated. No consistent changes in these in vitro immune functions were detected resulting from supranutritional feeding of either selenite or vitamin E or both. ... /Cystine/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

硒无论是以无机形式还是有机形式，都能从人体肠道中被迅速吸收，其总生物利用度分别为84%至97%。/硒/

Selenium, either as inorganic or organic forms, is rapidly absorbed from the human gut, with total bioavailability of 84% to 97%, respectively. /Selenium/

来源:Hazardous Substances Data Bank (HSDB)