2-trimethylstannyl-6-methoxybenzo[b]thiophene | 217660-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-trimethylstannyl-6-methoxybenzo[b]thiophene
• 英文别名: (6-Methoxy-1-benzothiophen-2-yl)-trimethylstannane
• CAS: 217660-37-2
• 化学式: C₁₂H₁₆OSSn
• 分子量: 327.034
• InChiKey: WXJSVNAJNLLBEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.46
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-二甲基溴苯 、 2-trimethylstannyl-6-methoxybenzo[b]thiophene 在 四(三苯基膦)钯 、 copper(II) oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以61%的产率得到2-(2,6-dimethylphenyl)-6-methoxybenzo[b]thiophene
  参考文献：
  名称：

  Synthesis of estradiol backbone mimics via the Stille reaction using copper(II) oxide as co-reagent

  摘要：

  Sterically hindered biaryls and 2-phenylbenzo[b]thiophenes that can serve as templates for mimics of the estradiol backbone were prepared in modest to good yields by the Stille reaction using CuO as a co-reagent. Due to the neutral conditions applied in the Stille reaction, protection strategies were unnecessary for hydroxy containing coupling partners. Ligandless coupling conditions were also evaluated. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.10.144
• 作为产物：
  描述：

  6-甲氧基苯并噻吩 、 三甲基氯化锡 在 正丁基锂 作用下， 以 四氢呋喃 、 环己烷 、 正己烷 为溶剂， 以77%的产率得到2-trimethylstannyl-6-methoxybenzo[b]thiophene
  参考文献：
  名称：

  Synthesis of estradiol backbone mimics via the Stille reaction using copper(II) oxide as co-reagent

  摘要：

  Sterically hindered biaryls and 2-phenylbenzo[b]thiophenes that can serve as templates for mimics of the estradiol backbone were prepared in modest to good yields by the Stille reaction using CuO as a co-reagent. Due to the neutral conditions applied in the Stille reaction, protection strategies were unnecessary for hydroxy containing coupling partners. Ligandless coupling conditions were also evaluated. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.10.144

文献信息

• Synthesis of estradiol backbone mimics via the Stille reaction using copper(II) oxide as co-reagent
  作者：Erik Flöistrup、Patrick Goede、Roger Strömberg、Johan Malm

  DOI：10.1016/j.tetlet.2010.10.144

  日期：2011.1

  Sterically hindered biaryls and 2-phenylbenzo[b]thiophenes that can serve as templates for mimics of the estradiol backbone were prepared in modest to good yields by the Stille reaction using CuO as a co-reagent. Due to the neutral conditions applied in the Stille reaction, protection strategies were unnecessary for hydroxy containing coupling partners. Ligandless coupling conditions were also evaluated. (C) 2010 Published by Elsevier Ltd.