2,2'-bis(6-chloro-1H-benzimidazole)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2,2'-bis(6-chloro-1H-benzimidazole)
• 英文别名: 6-chloro-2-(6-chloro-1H-benzimidazol-2-yl)-1H-benzimidazole
• 化学式: C₁₄H₈Cl₂N₄
• 分子量: 303.15
• InChiKey: KTBFPAZIOQPCOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2'-bis(6-chloro-1H-benzimidazole) 、 碘甲烷 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 49.0h， 以18%的产率得到1,1'-dimethyl-6,6'-dichloro-2,2'-bisbenzimidazole
  参考文献：
  名称：

  2,2'-双苯并咪唑体系的合成与反应

  摘要：

  两个2,2'-双苯并咪唑系统的亲核反应，即双（2 H-苯并咪唑-2-亚基）2和双螺[2 H-苯并咪唑-2,1'-环己烷-4'，2″ -2″报道了[ H-苯并咪唑] 3以及新的2,2'-双苯并咪唑的合成，并描述了它们向其他杂环的转化。

  DOI：

  10.1002/jhet.5570360429
• 作为产物：
  描述：

  六氯丙酮 、 4-氯-1,2-苯二胺 以 乙二醇 为溶剂， 反应 5.0h， 以50%的产率得到2,2'-bis(6-chloro-1H-benzimidazole)
  参考文献：
  名称：

  AN ALTERNATIVE PREPARATION OF BISBENZIMIDAZOLES

  摘要：

  The reaction of hexachloroacetone (HCA) with o-phenylene-diamines substituted with electron-donating groups leads to the formation of substituted bisbenzimidazoles in good yields.

  DOI：

  10.1081/scc-100000589

文献信息

• ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
  申请人：Dai Dongcheng

  公开号：US20110027227A1

  公开（公告）日：2011-02-03

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family is disclosed.
• Antiviral Drugs for Treatment of Arenvirus Infection
  申请人：SIGA TECHNOLOGIES, INC.

  公开号：US20140100245A1

  公开（公告）日：2014-04-10

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family is disclosed.
• US8623347B2
  申请人：——

  公开号：US8623347B2

  公开（公告）日：2014-01-07
• [EN] ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION<br/>[FR] MÉDICAMENTS ANTIVIRAUX POUR LE TRAITEMENT D'UNE INFECTION PAR UN ARÉNAVIRUS
  申请人：SIGA TECHNOLOGIES INC

  公开号：WO2009123776A2

  公开（公告）日：2009-10-08

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family is disclosed.
• Syntheses and reactions of 2,2′-bisbenzimidazole systems
  作者：Benita Von Glahn、Walter Kramer、Richard Neidlein、Hans Suschitzky

  DOI：10.1002/jhet.5570360429

  日期：1999.7

  Nucleophilic reactions of two 2,2′-bisbenzimidazole systems, namely the bis(2H-benzimidazole-2-ylidene) 2 and the dispiro[2H-benzimidazole-2,1′-cyclohexane-4′,2″-2″H-benzimidazole] 3, as well as the syntheses of new 2,2′-bisbenzimidazoles are reported and their conversion into other heterocycles is described.

  两个2,2'-双苯并咪唑系统的亲核反应，即双（2 H-苯并咪唑-2-亚基）2和双螺[2 H-苯并咪唑-2,1'-环己烷-4'，2″ -2″报道了[ H-苯并咪唑] 3以及新的2,2'-双苯并咪唑的合成，并描述了它们向其他杂环的转化。