3-(Furan-3-yl)-1H-pyrrole | 97586-49-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(Furan-3-yl)-1H-pyrrole
• CAS: 97586-49-7
• 化学式: C₈H₇NO
• 分子量: 133.15
• InChiKey: NBAOKSVTMJKLOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.9
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS
  申请人：BIAL - PORTELA & Cª, S.A.

  公开号：EP3515433A1

  公开（公告）日：2019-07-31
• [EN] BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS<br/>[FR] INHIBITEURS DE DOPAMINE-β-HYDROXYLASE PÉNÉTRANT DANS LA BARRIÈRE HÉMATO-ENCÉPHALIQUE
  申请人：BIAL PORTELA & Cª S A

  公开号：WO2018056854A1

  公开（公告）日：2018-03-29

  This invention relates to: (a) compounds of formula (I) (with R1 to R5, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.