N-(5-(methylthio)-4-phenylthiazol-2-yl)-2-oxo-2-phenylacetamide | 1619964-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-(methylthio)-4-phenylthiazol-2-yl)-2-oxo-2-phenylacetamide
• 英文别名: N-(5-methylsulfanyl-4-phenyl-1,3-thiazol-2-yl)-2-oxo-2-phenylacetamide
• CAS: 1619964-32-7
• 化学式: C₁₈H₁₄N₂O₂S₂
• 分子量: 354.453
• InChiKey: AHEXYUUTQIOSJV-UHFFFAOYSA-N

物化性质

• 密度：
  1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯乙酮 在 碘 、 对甲苯磺酸 、 copper(II) oxide 作用下， 以 甲醇 为溶剂， 生成 N-(5-(methylthio)-4-phenylthiazol-2-yl)-2-oxo-2-phenylacetamide
  参考文献：
  名称：

  Iodine-promoted selective synthesis of substituted aminothiazole via a self-sorting reaction network

  摘要：

  An iodine-promoted selective synthesis has been developed for the construction of substituted aminothiazole from easily available aryl methyl ketones and thiourea under metal free conditions. This domino process involves the cleavage of C-H, C-O, C-S bonds and the formation of C-N, C-O, C-S bonds. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.05.101

文献信息

• Iodine-promoted selective synthesis of substituted aminothiazole via a self-sorting reaction network
  作者：Wei-jian Xue、Kai-lu Zheng、Hong-zheng Li、Fang-fang Gao、An-xin Wu

  DOI：10.1016/j.tetlet.2014.05.101

  日期：2014.7

  An iodine-promoted selective synthesis has been developed for the construction of substituted aminothiazole from easily available aryl methyl ketones and thiourea under metal free conditions. This domino process involves the cleavage of C-H, C-O, C-S bonds and the formation of C-N, C-O, C-S bonds. (C) 2014 Elsevier Ltd. All rights reserved.