ethyl 2-(furan-2-carbonyl)-4-oxo-4-phenylbut-2-enoate | 1220125-89-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-(furan-2-carbonyl)-4-oxo-4-phenylbut-2-enoate
• 英文别名: ethyl (E)-2-(furan-2-carbonyl)-4-oxo-4-phenylbut-2-enoate
• CAS: 1220125-89-2
• 化学式: C₁₇H₁₄O₅
• 分子量: 298.295
• InChiKey: VBYCCGHRFFONQI-ACCUITESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  73.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯乙酮 在 copper(l) iodide 、 碘 、 copper(II) oxide 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 生成 ethyl 2-(furan-2-carbonyl)-4-oxo-4-phenylbut-2-enoate 、 ethyl 2-(furan-2-carbonyl)-4-oxo-4-phenylbut-2-enoate
  参考文献：
  名称：

  Target-oriented synthesis: miscellaneous synthetic routes to access 1,4-enediones through the coupling of 1,3-dicarbonyl compounds with multiform substrates

  摘要：

  Target-oriented synthetic protocol was presented for the synthesis of 1,4-enediones. The approach can efficiently construct 1,4-enediones through different reaction pathways from multiform substrates alpha-halo aromatic ketones, 2-hydroxy-aromatic ketones and methyl carbinols. In this reaction, CuI was found to be the most efficient catalyst. Multiform substrates were also found to perform well to afford the products in a one-pot fashion. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.106

文献信息

• Formation of Unsymmetrical 1,4-Enediones via A Focusing Domino Strategy: Cross-Coupling of 1,3-Dicarbonyl Compounds and Methyl Ketones or Terminal Aryl Alkenes
  作者：Meng Gao、Yan Yang、Yan-Dong Wu、Cong Deng、Li-Ping Cao、Xiang-Gao Meng、An-Xin Wu

  DOI：10.1021/ol100473f

  日期：2010.4.16

  A highly efficient synthesis of unsymmetrical 1,4-enediones from 1,3-dicarbonyl compounds and methyl ketones or terminal aryl alkenes has been developed via a focusing domino strategy. Simple and readily available starting materials, mild reaction conditions, and a very simple operation are advantages of the reaction, which allow straightforward synthesis of a variety of unsymmetrical 1,4-enediones

  通过聚焦多米诺骨牌战略已开发出一种由1,3-二羰基化合物和甲基酮或末端芳基烯烃高效合成不对称1,4-二烯键的方法。简单且容易获得的起始原料，温和的反应条件和非常简单的操作是反应的优势，可以直接合成各种不对称的1,4-二烯酮。
• Target-oriented synthesis: miscellaneous synthetic routes to access 1,4-enediones through the coupling of 1,3-dicarbonyl compounds with multiform substrates
  作者：Yan-ping Zhu、Qun Cai、Qing-he Gao、Feng-cheng Jia、Mei-cai Liu、Meng Gao、An-xin Wu

  DOI：10.1016/j.tet.2013.05.106

  日期：2013.8

  Target-oriented synthetic protocol was presented for the synthesis of 1,4-enediones. The approach can efficiently construct 1,4-enediones through different reaction pathways from multiform substrates alpha-halo aromatic ketones, 2-hydroxy-aromatic ketones and methyl carbinols. In this reaction, CuI was found to be the most efficient catalyst. Multiform substrates were also found to perform well to afford the products in a one-pot fashion. (C) 2013 Elsevier Ltd. All rights reserved.