5-(4-Nitrophenyl)-2-phenyl-6H-1,3,4-oxadiazin-6-on | 86997-04-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-Nitrophenyl)-2-phenyl-6H-1,3,4-oxadiazin-6-on
• 英文别名: 2-Phenyl-5-(4-nitrophenyl)-oxadiazinon；5-(4-Nitrophenyl)-2-phenyl-1,3,4-oxadiazin-6-one
• CAS: 86997-04-8
• 化学式: C₁₅H₉N₃O₄
• 分子量: 295.254
• InChiKey: XHCIVMSFMMRVCL-UHFFFAOYSA-N

物化性质

• 熔点：
  208-210 °C
• 沸点：
  450.3±47.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  cyclopropene 、 5-(4-Nitrophenyl)-2-phenyl-6H-1,3,4-oxadiazin-6-on 以 四氢呋喃 为溶剂， 以70%的产率得到3-(4-Nitrophenyl)-7-phenyl-2(5H)-oxepinon
  参考文献：
  名称：

  Christl, Manfred; Lanzendoerfer, Ulrike; Hegmann, Joachim, Chemische Berichte, 1985, vol. 118, # 7, p. 2940 - 2973

  摘要：

  DOI：
• 作为产物：
  描述：

  4-硝基苯乙醛酸 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.0h， 生成 5-(4-Nitrophenyl)-2-phenyl-6H-1,3,4-oxadiazin-6-on
  参考文献：
  名称：

  Christl, Manfred; Lanzendoerfer, Ulrike; Hegmann, Joachim, Chemische Berichte, 1985, vol. 118, # 7, p. 2940 - 2973

  摘要：

  DOI：

文献信息

• Cycloadditionen von 6H-1,3,4-Oxadiazin-6-onen (4,5-Diaza-?-Pyronen). 14. Nicht katalysierte und durch Trifluoressigs�ure katalysierte Reaktionen von 6H-1,3,4-Oxadiazin-6-onen mit Norbornen
  作者：Manfred Christl、Gabriele Bodenschatz、Erich Feineis、Joachim Hegmann、Gerhard H�ttner、Stefan Mertelmeyer、Klaus Sch�tzlein、Hartmut Schwarz

  DOI：10.1002/prac.199533701140

  日期：——

  In 11 out of 13 non-catalysed reactions of oxadiazinones 1 with norbornene, gamma-oxoketenes 4 were observed and could be isolated in three cases (4b,d,m). Except for 4m, all gamma-oxoketenes isomerised to enollactones of type 5 on thermolysis. However, 4b furnished the cyclobutene derivative 10 as the major product. No gamma-oxoketenes were detected in the reactions of Ik and 11, which gave rise to the formation of 5k and the enollactone 19, respectively. The latter was converted into 51 on treatment with trifluoroacetic acid (TFA). Four oxadiazinones 1 were allowed to react with norbornene in the presence of TFA. Three of them (1a,b,l) afforded mixtures of enollactones of type 5 and their diastereomers 12. Heating of 4 in the presence of norbornene led to the formation of the symmetrical delta-lactones 6. This process was observed to be efficient only where the conversion 4 --> 5 is slow (4b) or inoperative (4m). In five cases, the treatment of the components with boron trifluoride etherate proved to be a useful preparative alternative (6a,d,g,h,m). On treatment of 4a with methanol, the pseudoester 7a was formed, whereas 4b gave mixtures of 7b and the esters 8b and 15. Hydrogen chloride converted 4b into the pseudochloride 14, which furnished pseudoester 7b on methanolysis. Reaction of 4b,m with formic acid gave rise to pseudoanhydrides of type 13. From 4b and TFA a mixture of the enollactones 5b and 12b was obtained. Boron trifluoride etherate transformed 4i to enollactone 12i; analogously, 12m resulted on treatment of 4m with trifluoromethanesulfonic acid.
• Christl, Manfred; Bodenschatz, Gabriele; Feineis, Erich, Liebigs Annalen, 1996, # 5, p. 853 - 861
  作者：Christl, Manfred、Bodenschatz, Gabriele、Feineis, Erich、Hegmann, Joachim、Huettner, Gerhard、Mertelmeyer, Stefan、Schaetzlein, Klaus

  DOI：——

  日期：——
• Reaktivität von stickstoff-heterocyclen genenüber cyclooctin als dienophil
  作者：J. Balcar、G. Chrisam、F.X. Huber、J. Sauer

  DOI：10.1016/s0040-4039(00)81687-1

  日期：——
• BALCAR, J.;CHRISAM, G.;HUBER, F. X.;SAUER, J., TETRAHEDRON LETT., 1983, 24, N 14, 1481-1484
  作者：BALCAR, J.、CHRISAM, G.、HUBER, F. X.、SAUER, J.

  DOI：——

  日期：——
• CHRISTL, M.;LANZENDOERFER, U.;HEGMANN, J.;PETERS, K.;PETERS, E. -M.;SCHNE+, CHEM. BER., 1985, 118, N 7, 2940-2973
  作者：CHRISTL, M.、LANZENDOERFER, U.、HEGMANN, J.、PETERS, K.、PETERS, E. -M.、SCHNE+

  DOI：——

  日期：——