N-(4-methoxyphenyl)-N-(1-phenylbut-3-enyl)formamide | 1190108-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-methoxyphenyl)-N-(1-phenylbut-3-enyl)formamide
• CAS: 1190108-20-3
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.354
• InChiKey: IPNAFPXBLFHFRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-methoxyphenyl)-N-(1-phenylbut-3-enyl)formamide 在 titanium(IV) isopropylate 、 环戊基溴化镁 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以15%的产率得到
  参考文献：
  名称：

  Diastereoselective Ti-mediated preparation of bicyclic aminocyclopropanes from N-alkenyl amides

  摘要：

  Intramolecular Ti-mediated alkene-amide couplings of a range of N-alk-3-enyl amides fitted with a substituent at the homoallylic position are described. CF3-substituted compounds are suitable substrates and bicyclic aminocyclopropanes bearing a CF3 group can be prepared in this way. Good diastereoselectivities can be observed depending on the substitution pattern, and best results are obtained in diethyl ether rather than in THF. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.031
• 作为产物：
  描述：

  4-methoxy-N-(1-phenylbut-3-enyl)aniline 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N-(4-methoxyphenyl)-N-(1-phenylbut-3-enyl)formamide
  参考文献：
  名称：

  Diastereoselective Ti-mediated preparation of bicyclic aminocyclopropanes from N-alkenyl amides

  摘要：

  Intramolecular Ti-mediated alkene-amide couplings of a range of N-alk-3-enyl amides fitted with a substituent at the homoallylic position are described. CF3-substituted compounds are suitable substrates and bicyclic aminocyclopropanes bearing a CF3 group can be prepared in this way. Good diastereoselectivities can be observed depending on the substitution pattern, and best results are obtained in diethyl ether rather than in THF. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.031

文献信息

• Diastereoselective Ti-mediated preparation of bicyclic aminocyclopropanes from N-alkenyl amides
  作者：Claire Madelaine、Andrea K. Buzas、Justyna A. Kowalska-Six、Yvan Six、Benoît Crousse

  DOI：10.1016/j.tetlet.2009.07.031

  日期：2009.9

  Intramolecular Ti-mediated alkene-amide couplings of a range of N-alk-3-enyl amides fitted with a substituent at the homoallylic position are described. CF3-substituted compounds are suitable substrates and bicyclic aminocyclopropanes bearing a CF3 group can be prepared in this way. Good diastereoselectivities can be observed depending on the substitution pattern, and best results are obtained in diethyl ether rather than in THF. (C) 2009 Elsevier Ltd. All rights reserved.