4'-bromo-2-methoxybiphenyl | 169691-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-bromo-2-methoxybiphenyl
• 英文别名: 4'-bromo-2-methoxy-1,1'-biphenyl；4-Bromo-2'-methoxybiphenyl；1-bromo-4-(2-methoxyphenyl)benzene
• CAS: 169691-87-6
• 化学式: C₁₃H₁₁BrO
• 分子量: 263.134
• InChiKey: DVFZTLPDJYSVOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4'-bromo-2-methoxybiphenyl 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以82%的产率得到2-(4-溴苯基)苯酚
  参考文献：
  名称：

  Cu-Catalyzed Oxidative C(sp²)–H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans

  摘要：

  A new process involving copper-catalyzed aerobic C(sp(2))-H activation, followed by cycloetherification, has been developed. This reaction serves as a direct method for the preparation of multisubstituted dibenzofurans starting with o-arylphenols. The presence of a strong para-electron-withdrawing group (e.g., NO2) on the phenol is essential for the success of the reaction.

  DOI：

  10.1021/ol203442a
• 作为产物：
  描述：

  2-甲氧基联苯 在 N-溴代丁二酰亚胺(NBS) 、 碘苯二乙酸 、 [NiBr(C₅H₃N(C₃H₂N₂Me)2)]Br 作用下， 以 重水 为溶剂， 反应 24.0h， 以56.5%的产率得到4'-bromo-2-methoxybiphenyl
  参考文献：
  名称：

  Ni(II) catalyzed bromination of aryl C–H bonds

  摘要：

  Bromination of unactivated aromatic C-H bonds without directing and/or chelating groups was achieved by employing an air stable N-heterocyclic Ni(II) complex. PhI(OAC)(2) and N-bromosuccinimide have been used as the oxidizing agent and the bromine source, respectively. Yields for bromination are as high as >99%, especially in presence of electron-withdrawing groups like -NO2 and -CF3. This is a rare report on C-H bond activation with Ni(II) where, instead of homo C-C coupling, reductive elimination to form C-halogen could be achieved. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.08.012

文献信息

• [EN] SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY<br/>[FR] DÉRIVÉS D'OXINDOLE SPIRO-SUBSTITUÉS AYANT UNE ACTIVITÉ SUR AMPK
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014202580A1

  公开（公告）日：2014-12-24

  The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  本发明涉及具有有价值的药理特性的式(I)化合物，特别是AMPK激活剂，因此在治疗某些可以通过激活该受体预防或治疗的疾病方面具有用处。这些化合物适用于治疗和预防可以受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
• Magnetite@MCM‐41 nanoparticles as support material for Pd‐ <i>N</i> ‐heterocyclic carbene complex: A magnetically separable catalyst for Suzuki–Miyaura reaction
  作者：Mitat Akkoç、Nesrin Buğday、Serdar Altın、Sedat Yaşar

  DOI：10.1002/aoc.6233

  日期：2021.6

  coupled plasma–optical emission spectroscopy (ICP‐OES) analysis. The catalytic activity of Magnetite@MCM‐41@NHC@Pd heterogeneous catalyst done on Suzuki–Miyaura reactions of aryl halides with different substituted arylboronic acid derivatives. All coupling reactions afforded excellent yields and up to 408404 Turnover Frequency (TOF) h−1 in the presence of 2 mg of Magnetite@MCM‐41@NHC@Pd catalyst (0.0564 mmol g−1

  磁铁矿@ MCM-41 @ NHC @ Pd催化剂是通过将与NHC配体结合的Pd金属锚定在Fe 3 O 4的表面上而制得的@ MCM‐41。它的特征在于傅立叶变换红外（FTIR）光谱，透射电子显微镜（TEM），X射线衍射（XRD），X射线光电子能谱（XPS），能量色散X射线分析（EDX），热重分析（TGA） ），差热分析（​​DTA）和扫描电子显微镜（SEM）。Magnetite @ MCM-41 @ NHC @ Pd中的Pd含量通过电感耦合等离子体发射光谱法（ICP-OES）分析。磁铁矿@ MCM-41 @ NHC @ Pd的非均相催化剂对芳基卤化物与不同取代的芳基硼酸衍生物的Suzuki-Miyaura反应的催化活性。所有偶联反应均具有出色的收率，最高可达408404的周转频率（TOF）h -1在2毫克磁铁矿的存在@ MCM-41 @ NHC @的Pd催化剂（0.0564毫摩尔克-1，0
• [EN] OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY<br/>[FR] OXINDOLES SUBSTITUÉS PAR OLÉFINE AYANT UNE ACTIVITÉ SUR AMPK
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014202528A1

  公开（公告）日：2014-12-24

  The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  本发明涉及具有有价值的药理特性的式(I)化合物，特别是AMPK激活剂，因此在治疗某些可以通过激活该受体预防或治疗的疾病方面具有用处。这些化合物适用于治疗和预防可以受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
• Highly Active Fe3O4@SBA-15@NHC-Pd Catalyst for Suzuki–Miyaura Cross-Coupling Reaction
  作者：Mitat Akkoç、Nesrin Buğday、Serdar Altın、İsmail Özdemir、Sedat Yaşar

  DOI：10.1007/s10562-021-03755-w

  日期：2022.6

  Fe3O4@SBA-15@NHC-Pd. The TEM images of the catalyst showed the existence of palladium nanoparticles immobilized in the catalyst's structure, while no reducing agent was used. The NHC moieties in the catalyst structure could be stabilize Pd(0) nanoparticles prevents agglomeration. The magnetic catalyst was effectively used in the Suzuki–Miyaura cross-coupling reaction of substituted phenylboronic acid derivatives

  合成了一种新型 Pd-NHC 功能化磁性 Fe 3 O 4 @SBA-15@NHC-Pd，并将其用作 Suzuki-Miyaura C-C 键形成反应中的高效非均相催化剂。Fe 3 O 4 @SBA-15@NHC-Pd 通过 X 射线衍射 (XRD)、X 射线光电子能谱 (XPS)、傅里叶变换红外 (FTIR) 光谱、扫描电子显微镜 (SEM)、透射电子显微镜进行表征(TEM)、能量色散 X 射线分析 (EDX)、热重分析 (TGA)、差热分析 (DTA)。电感耦合等离子体发射光谱 (ICP-OES) 分析用于确定 Fe 3 O 4中 Pd (0.33 wt%) 的准确量@SBA-15@NHC-PD。催化剂的 TEM 图像显示存在固定在催化剂结构中的钯纳米颗粒，而没有使用还原剂。催化剂结构中的 NHC 部分可以稳定 Pd(0) 纳米颗粒，防止聚集。磁性催化剂有效地用于取代苯基硼酸衍生物与（杂）芳基溴化物的
• 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND
  申请人：Kuribayashi Takeshi

  公开号：US20110112103A1

  公开（公告）日：2011-05-12

  The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: [wherein, R 1 represents a group —X-Q 1 , X-Q 1 -Y-Q 2 or X-Q 1 -Y-Q 2 -Z-Q 3 , X represents a single bond, —CH 2 — or the like, Q 1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, —CH 2 —, or the like, Q 2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, —CR 11 R 12 — or the like, R 11 and R 12 each independently represents a hydrogen atom, a halogen atom or the like, Q 3 represents a phenyl group which may have substituent(s), a C 3 -C 7 cycloalkyl group which may have substituent(s), a C 3 -C 7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R 2 represents a C 1 -C 3 alkyl group or the like, and R 3 represents a hydrogen atom or a methyl group].

  本发明提供促进促红细胞生成素产生的化合物。提供以下一般式（1）表示的化合物或其药理学上可接受的盐： [其中，R 1 表示一个基团-X-Q 1 ，X-Q 1 -Y-Q 2 或X-Q 1 -Y-Q 2 -Z-Q 3 ，X表示一个单键，-CH 2 -或类似物，Q 1 表示可能具有取代基的单环或双环杂环基团，Y表示一个单键，-CH 2 -或类似物，Q 2 表示可能具有取代基的单环或双环碳氢环基团或可能具有取代基的单环或双环杂环基团，Z表示一个单键，-CR 11 R 12 -或类似物，R 11 和R 12 各自独立地表示氢原子、卤素原子或类似物，Q 3 表示可能具有取代基的苯基团，可能具有取代基的C 3 -C 7 环烷基团，可能具有取代基的C 3 -C 7 环烯基团或可能具有取代基的单环或双环杂环基团，R 2 表示C 1 -C 3 烷基团或类似物，R 3 表示氢原子或甲基基团]。