(4-tert-butyl-phenyl)-tert-butylmine | 36209-85-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-tert-butyl-phenyl)-tert-butylmine
• 英文别名: N,4-di-tert-butylaniline；4,N-di-tert-butyl-aniline；4,N-Di-tert-butyl-anilin；N-t-Butyl-p-t-butylanilin；Aniline, N-tert-butyl-4-tert-butyl-；N,4-ditert-butylaniline
• CAS: 36209-85-5
• 化学式: C₁₄H₂₃N
• 分子量: 205.343
• InChiKey: YKQQYQHMSGJYTG-UHFFFAOYSA-N

物化性质

• 沸点：
  286.7±19.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-tert-butyl-phenyl)-tert-butylmine 、 乙酰氯 生成 acetic acid-(4,N-di-tert-butyl-anilide)
  参考文献：
  名称：

  Studer, Chemische Berichte, 1881, vol. 14, p. 1474

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-t-butylphenyl)-N-t-butylhydroxylamine 在 二溴亚砜 、 叔丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 34.75h， 生成 (4-tert-butyl-phenyl)-tert-butylmine
  参考文献：
  名称：

  Hetero-Cope rearrangement for the synthesis of potassium 5-tert-butyl-2-(tert-butyl-aminoxy)-benzoate, a highly water-soluble stable free radical

  摘要：

  The hetero-Cope rearrangement of 4-tert-butyl-phenyl-tert-butylhydroxylamine provides an easy access to the corresponding ortho-bromoaniline, converted to the new highly water-soluble nitroxide, potassium 5-tert-butyl-2-(tert-butyl-aminoxy)benzoate. The parent carboxylic acid was found to be very persistent in water at pH 1. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00311-8

文献信息

• (DiMeIHept^Cl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination
  作者：Volodymyr Semeniuchenko、Sepideh Sharif、Jonathan Day、Nalin Chandrasoma、William J. Pietro、Jeffrey Manthorpe、Wilfried M. Braje、Michael G. Organ

  DOI：10.1021/acs.joc.1c01057

  日期：2021.8.6

  (DiMeIHeptCl)Pd, a hyper-branched N-aryl Pd NHC catalyst, has been shown to be efficient at performing amine arylation reactions in solvent-free (“melt”) conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center serves as lubricant to allow the complex to navigate through the paste-like environment of these mixtures. The protocol can be used on a multi-gram scale to make

  (DiMeIHept Cl )Pd是一种超支化 N-芳基 Pd NHC 催化剂，已被证明在无溶剂（“熔融”）条件下可有效地进行胺芳基化反应。Pd 中心侧翼烷基链的高度亲油环境充当润滑剂，使复合物能够通过这些混合物的糊状环境。该协议可用于多克规模，以制造各种苯胺衍生物，包括含有醇部分的底物。
• NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20170217970A1

  公开（公告）日：2017-08-03

  To provide a novel compound having a HER2 inhibitory effect and having a cytostatic effect. It is also intended to provide a medicament useful in the prevention and/or treatment of a disease involving HER2, particularly, cancer, on the basis of the HER2 inhibitory effect. The present invention provides a compound of formula (I) wherein X, Y, Z 1 , Z 2 , Z 3 , Z 4 , W, n, R 1 , R 2 , and R 3 have meanings as defined in the present specification, or a salt thereof.

  提供一种具有HER2抑制作用和细胞静止作用的新化合物。还旨在提供一种药物，基于HER2抑制作用，可用于预防和/或治疗涉及HER2的疾病，特别是癌症。本发明提供一种具有以下结构的化合物（I），其中X、Y、Z1、Z2、Z3、Z4、W、n、R1、R2和R3的含义如本说明书中定义，或其盐。
• PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS
  申请人：Fink Brian E.

  公开号：US20090048244A1

  公开（公告）日：2009-02-19

  The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明提供公式I化合物及其药学上可接受的盐。公式I化合物抑制生长因子受体的酪氨酸激酶活性，如HER1、HER2和HER4，因此使它们有用作抗增殖剂。公式I化合物也适用于治疗与通过生长因子受体进行信号转导途径相关的其他疾病。
• AURISTATIN DRUG LINKER CONJUGATES
  申请人：Senter Peter

  公开号：US20110020343A1

  公开（公告）日：2011-01-27

  Drug Linker compounds and Drug Linker Ligand conjugates are provided that have auristatins linked via the C-terminus. The conjugates show efficacy without the need for a self-immolative group to release the drug.

  提供了药物连接剂化合物和药物连接剂配体偶联物，其通过C-末端连接有奥利司他。这些偶联物在无需自解离基团释放药物的情况下表现出有效性。
• Long persistent luminescence emitter and long persistent luminescent element
  申请人：KYUSHU UNIVERSITY, NATIIONAL UNIVERSITY CORPORATION

  公开号：US10301540B2

  公开（公告）日：2019-05-28

  The invention discloses a long persistent luminescence emitter which has an electron-donating molecule that is stable in the radical cation state and an electron-accepting molecule that is stable in the radical anion state and from which luminescence is observed at 10 K after photo-irradiation of the long persistent luminescence emitter stops. According to the disclosed invention, persistent luminescence can be exhibited for a long time with only organic compounds without the use of any rare-earth elements.

  本发明公开了一种长持续发光发射体，该发射体具有在自由基阳离子状态下稳定的供电子分子和在自由基阴离子状态下稳定的受电子分子，在停止对长持续发光发射体进行光照射后，可在 10 K 温度下观察到该发射体发光。根据本发明，只需使用有机化合物，而无需使用任何稀土元素，就能长时间发出持久性发光。

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