tert-butyl (tert-butoxycarbonyl)oxy[2-(3-nitrophenyl)prop-2-enyl]carbamate | 1369515-99-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (tert-butoxycarbonyl)oxy[2-(3-nitrophenyl)prop-2-enyl]carbamate
• CAS: 1369515-99-0
• 化学式: C₁₉H₂₆N₂O₇
• 分子量: 394.425
• InChiKey: ITAHJJLCNSUCQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.71
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  108.21
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  1-碘-3-硝基苯 、 丙二烯 、 N,O-二叔丁氧羰基-羟胺 在 tris-(dibenzylideneacetone)dipalladium(0) 、 三(2-呋喃基)膦 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 80.0 ℃ 、101.33 kPa 条件下， 反应 16.0h， 以67%的产率得到tert-butyl (tert-butoxycarbonyl)oxy[2-(3-nitrophenyl)prop-2-enyl]carbamate
  参考文献：
  名称：

  Skeletal diversity via Pd(0) catalysed three-component cascades of allene and halides or triflates with protected hydroxylamines and formamide

  摘要：

  The reactions of allene gas (1 atm) and of 1,1-dimethylallene with a range protected hydroxylamines and formamide with aryl/heteroaryl iodides, bromides and triflates under Pd(0) catalysis lead to a skeletally diverse range of products in good yield. The cascades tolerate both electron withdrawing and electron donating substrates and 1,1-dimethylallene reacts regioselectively in all cases. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.099

文献信息

• Skeletal diversity via Pd(0) catalysed three-component cascades of allene and halides or triflates with protected hydroxylamines and formamide
  作者：Elghareeb E. Elboray、Chuanjun Gao、Ronald Grigg

  DOI：10.1016/j.tet.2012.01.099

  日期：2012.4

  The reactions of allene gas (1 atm) and of 1,1-dimethylallene with a range protected hydroxylamines and formamide with aryl/heteroaryl iodides, bromides and triflates under Pd(0) catalysis lead to a skeletally diverse range of products in good yield. The cascades tolerate both electron withdrawing and electron donating substrates and 1,1-dimethylallene reacts regioselectively in all cases. (C) 2012 Elsevier Ltd. All rights reserved.