Z-Gly-Gly-Arg-betana hydrochloride | 1442-79-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Gly-Gly-Arg-betana hydrochloride
• 英文别名: benzyl N-[2-[[2-[[(2S)-5-(diaminomethylideneamino)-1-(naphthalen-2-ylamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate;hydrochloride
• CAS: 1442-79-1
• 化学式: C28H34ClN7O5
• mdl: MFCD00038939
• 分子量: 584.1
• InChiKey: BVFJVGPYUPGGDO-BQAIUKQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.49
• 重原子数：
  41
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  190
• 氢给体数：
  7
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S36
• 危险类别码：
  R40

文献信息

• Process for determining inhibitor-enzyme complexes
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP0048989A2

  公开（公告）日：1982-04-07

  This invention relates to methods for detecting, identifying and quantifying enzymes, for example, human proteolytic enzymes. The method broadly comprises forming an immobilized or insoluble complex comprising enzyme, enzyme inhibitor and enzyme inhibitor-antibody reactive site and then detecting and identifying, preferably quantitatively, one or more enzymes bound to the complex. In a preferrend embodiment, a matrix, e.g. solid or semisolid surface or permeable matrix, has affixed thereto enzyme inhibitor-antibody or an immunologically active (inhibitor binding) fragment of such an antibody. This insoluble enzyme inhibitor interacting matrix is then contacted with biological fluid, e.g. body fluid, to bind one or more predetermined enzyme inhibitor-enzyme complexes, if present in the biological fluid. The bound enzyme is then detected, identified and preferably quantified.

  本发明涉及检测、鉴定和定量酶的方法，例如人类蛋白水解酶。该方法大致包括形成由酶、酶抑制剂和酶抑制剂-抗体反应位点组成的固定化或不溶性复合物，然后检测和鉴定（最好是定量检测和鉴定）与该复合物结合的一种或多种酶。 在一个优选的实施方案中，基质（例如固体或半固体表面或可渗透基质）上贴有酶抑制剂-抗体或这种抗体的免疫活性（抑制剂结合）片段。然后将这种不溶性酶抑制剂相互作用基质与生物液体（如体液）接触，以结合生物液体中存在的一种或多种预定的酶抑制剂-酶复合物。然后对结合的酶进行检测、鉴定和优选定量。
• Detection of Bacteroides gingivalis
  申请人：THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

  公开号：EP0292708A2

  公开（公告）日：1988-11-30

  The present invention relates to the detection of B. gingivalis by the specific ability of B. gingivalis to hydrolyze N-carbobenzoxy-glycyl-glycyl-L-arginine-B-napthylamide deriva­tives. The present invention also relates to the use of assay systems which inhibit serum amino peptidase and enhance the detection of the B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system inhibits the serum enzyme by the use of a serum aminopeptidase inhibitor which inhibits the activity of serum aminopeptidase to a greater extent than it inhibits the activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase. The assay system also increases the reliability of detection of the B. gingivalis enzyme by the use of enhancing materials which enhance the enzyme activity of B. gingivalis N-CBz-Gly-Gly-Arg peptidase to a greater extent than such materials enhance the enzyme activity of serum aminopeptidase.

  本发明涉及通过牙龈杆菌水解 N-羧基苯氧基-甘氨酰-甘氨酰-L-精氨酰-B-萘酰胺衍生物的特异性能力来检测牙龈杆菌。本发明还涉及抑制血清氨基肽酶并提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶检测能力的检测系统的使用。该检测系统通过使用血清氨基肽酶抑制剂来抑制血清酶，该抑制剂对血清氨基肽酶活性的抑制程度大于对牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶活性的抑制程度。该检测系统还通过使用增强材料提高牙龈杆菌 N-CBz-Gly-Gly-Arg 肽酶的酶活性，其增强程度大于此类材料对血清氨肽酶酶活性的增强程度，从而提高检测牙龈杆菌酶的可靠性。
• US4994376A
  申请人：——

  公开号：US4994376A

  公开（公告）日：1991-02-19