N-[(1Z)-2-phenyl-1-[[(phenylmethyl)amino]carbonyl]ethenyl]benzamide | 99875-11-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(1Z)-2-phenyl-1-[[(phenylmethyl)amino]carbonyl]ethenyl]benzamide
• 英文别名: N-[(1Z)-3-(benzylamino)-3-oxo-1-phenylprop-1-en-2-yl]benzamide；(Z)-2-(N-benzoylamino)cinnamamide；N-[(Z)-3-(benzylamino)-3-oxo-1-phenylprop-1-en-2-yl]benzamide
• CAS: 99875-11-3
• 化学式: C₂₃H₂₀N₂O₂
• 分子量: 356.424
• InChiKey: ZBTYFIVKRZUEAY-PGMHBOJBSA-N

物化性质

• 沸点：
  661.6±55.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[(1Z)-2-phenyl-1-[[(phenylmethyl)amino]carbonyl]ethenyl]benzamide 在 sodium acetate 、 溶剂黄146 作用下， 反应 4.0h， 生成 3-benzyl-5-benzylidene-2-phenyl-3,5-dihydro-imidazol-4-one
  参考文献：
  名称：

  A Facile Synthesis ofN-Substituted 2-Acylamino-2-alkenamides

  摘要：

  DOI：

  10.1055/s-1985-31179
• 作为产物：
  描述：

  苄胺 、 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 以 苯 为溶剂， 反应 10.0h， 以75%的产率得到N-[(1Z)-2-phenyl-1-[[(phenylmethyl)amino]carbonyl]ethenyl]benzamide
  参考文献：
  名称：

  Abdallah; Zayed; Shawali, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 3, p. 187 - 190

  摘要：

  DOI：

文献信息

• α-amino acrylate microbicide, and preparation method therefor and uses thereof
  申请人：NANKAI UNIVERSITY

  公开号：US11166460B2

  公开（公告）日：2021-11-09

  The present invention relates to a microbicidal α-amino acrylic derivative and its preparation method and applications. Based on the principle of pesticide molecular design, the structural reform of the agricultural anti-plant virus activity is carried on lead compounds having the medical anti-coronavirus activity, and a series of α-amino acrylic derivatives are designed and synthesized, and in particular, α-amino acrylic derivatives containing piperidine rings are synthesized, and the systematic biological activity screening is carried by using known compounds as positive control compounds, which provide many effective anti-virus leading molecules for the preparation of pesticides, and has positive significance to reduce the pesticide application dosage and protect the environment and ecology.

  本发明涉及一种杀微生物的α-氨基丙烯酸衍生物及其制备方法和应用。根据农药分子设计原理，对具有医用抗柯洛病毒活性的先导化合物进行农业抗植物病毒活性的结构改造，设计合成了一系列α-氨基丙烯酸衍生物，特别是合成了含有哌啶环的α-氨基丙烯酸衍生物、并以已知化合物为阳性对照化合物进行了系统的生物活性筛选，为农药制备提供了多种有效的抗病毒先导分子，对减少农药用量、保护环境和生态具有积极意义。
• Synthesis of 4-benzylidene-oxazol-5(4H)-imines, structural analogs of PK11195, under Bischler-Napieralski conditions
  作者：Marco A. Almaraz-Girón、Alfredo Vázquez

  DOI：10.1016/j.tetlet.2017.01.047

  日期：2017.2

  A simple and convenient one-pot procedure to prepare 4-benzylidene-2-aryl-1,3-oxazol-5(4H)-imines from phenyl pyruvic acid and a series of arylamides, under classical Bischler-Napieralski (B-N) conditions and microwave heating (MW) has been developed. The structures of the prepared compounds were unambiguously assigned through single crystal X-ray diffraction studies. The compounds thus prepared can be used to synthesize bioactive compounds with different molecular architectures. (C) 2017 Elsevier Ltd. All rights reserved.
• Phelps, David J.; Godreau, Paul V.; Nicholas, Everton S., Journal of the Chemical Society. Perkin transactions II, 1981, p. 140 - 142
  作者：Phelps, David J.、Godreau, Paul V.、Nicholas, Everton S.

  DOI：——

  日期：——
• a-Amino Acrylate microbicide, and preparation method therefor and uses thereof
  申请人：NANKAI UNIVERSITY

  公开号：US20200236935A1

  公开（公告）日：2020-07-30

  The present invention relates to a microbicidal α-amino acrylic derivative and its preparation method and applications. Based on the principle of pesticide molecular design, the structural reform of the agricultural anti-plant virus activity is carried on lead compounds having the medical anti-coronavirus activity, and a series of α-amino acrylic derivatives are designed and synthesized, and in particular, α-amino acrylic derivatives containing piperidine rings are synthesized, and the systematic biological activity screening is carried by using known compounds as positive control compounds, which provide many effective anti-virus leading molecules for the preparation of pesticides, and has positive significance to reduce the pesticide application dosage and protect the environment and ecology.
• Abdallah; Zayed; Shawali, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 3, p. 187 - 190
  作者：Abdallah、Zayed、Shawali

  DOI：——

  日期：——