dichloromaleic anhydride | 42595-14-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dichloromaleic anhydride
• 英文别名: 3,4-dichlorotetrahydrofurane-2,5-dione；d,l-1.2-dichlorosuccinic-anhydrid；meso-2,3-Dichlor-succinanhydrid；rac.-Dichlorbernsteinsaeureanhydrid；racem-2,3-Dichlor-bernsteinsaeureanhydrid；(2R*,3R*)-2,3-Dichlorosuccinic anhydride；2,3-Dichlor-bernsteinsaeure-anhydrid；2,3-dichloro-succinic acid anhydride；2,3-Dichlorosuccinic anhydride；3,4-Dichloro-dihydrofuran-2,5-dione；3,4-dichlorooxolane-2,5-dione
• CAS: 42595-14-2
• 化学式: C₄H₂Cl₂O₃
• 分子量: 168.964
• InChiKey: BCYJPLWSTIDSOV-UHFFFAOYSA-N

物化性质

• 熔点：
  118.3 °C
• 沸点：
  327.0±42.0 °C(Predicted)
• 密度：
  1.66±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dichloromaleic anhydride 在 甲烷 、 barium(II) chloride 作用下， 以151.8 g的产率得到3,4-二氟氯苯
  参考文献：
  名称：

  一种制备2-氯马来酸酐的方法

  摘要：

  本发明涉及有机合成技术领域，具体涉及一种制备2‑氯马来酸酐的方法，包括如下步骤：在反应瓶中加入马来酸酐，加热到固体融化后，加入三氯化铁，用泵将反应液打入混合模块；将氯气通入混合模块，将微通道反应模块加热后，混合模块中的反应液以一定流速通过微通道反应模块；后接一个装有固定床的微反应器，将微反应器温度加热，并采用氯化钡和活性炭组成的混合催化剂，通过微通道反应器的反应液进入固定床微反应器反应，同时以一定速率通入氮气，带走反应生成的氯化氢气体，收集反应液，蒸馏得到2‑氯马来酸酐。本发明采用氯化钡和活性炭组成的混合催化剂，反应速度快，产品收率和纯度均较高，降低了对设备的要求。

  公开号：

  CN112321548A
• 作为产物：
  描述：

  马来酸酐 在 iron(III) chloride 、 氯 作用下， 生成 dichloromaleic anhydride
  参考文献：
  名称：

  一种制备2-氯马来酸酐的方法

  摘要：

  本发明涉及有机合成技术领域，具体涉及一种制备2‑氯马来酸酐的方法，包括如下步骤：在反应瓶中加入马来酸酐，加热到固体融化后，加入三氯化铁，用泵将反应液打入混合模块；将氯气通入混合模块，将微通道反应模块加热后，混合模块中的反应液以一定流速通过微通道反应模块；后接一个装有固定床的微反应器，将微反应器温度加热，并采用氯化钡和活性炭组成的混合催化剂，通过微通道反应器的反应液进入固定床微反应器反应，同时以一定速率通入氮气，带走反应生成的氯化氢气体，收集反应液，蒸馏得到2‑氯马来酸酐。本发明采用氯化钡和活性炭组成的混合催化剂，反应速度快，产品收率和纯度均较高，降低了对设备的要求。

  公开号：

  CN112321548A

文献信息

• [EN] REVERSIBLE NONDEPOLARIZING NEUROMUSCULAR BLOCKADE AGENTS AND METHODS FOR THEIR USE<br/>[FR] AGENTS DE BLOCAGE NEUROMUSCULAIRES NON DÉPOLARISANTS RÉVERSIBLES ET LEUR MÉTHODE
  申请人：UNIV CORNELL

  公开号：WO2010107488A1

  公开（公告）日：2010-09-23

  The invention provides neuromuscular blockade agents of the non-depolarizing type with few if any circulatory effects. Compounds of the invention include bis(isoquinolylalkanol) diesters of fumaric, maleic, succinic, and acetylenedicarboxylic acids; compositions suitable for parenteral administration of these compounds as a surgical adjunct to anesthesia, and methods of preparation of the compounds. Compounds of the invention can produce neuromuscular blockade of short or intermediate duration, which for various compounds can be reversed by administration of a thiol compound such as L-cysteine, D-cysteine or glutathione. For various compounds of the invention, the neuromuscular blockade effect can be reversed quickly, efficiently, and without notable side-effects.

  该发明提供了一种非去极化型神经肌肉阻滞剂，几乎没有任何循环效应。该发明的化合物包括富马酸、马来酸、琥珀酸和乙炔二羧酸的双(异喹啉基烷醇)二酯；适用于这些化合物作为手术辅助麻醉剂的静脉给药组合物，以及这些化合物的制备方法。该发明的化合物可以产生短暂或中等持续时间的神经肌肉阻滞，对于各种化合物，可以通过给予硫醇化合物如L-半胱氨酸、D-半胱氨酸或谷胱甘肽来逆转。对于该发明的各种化合物，神经肌肉阻滞效应可以迅速、高效地逆转，而且没有明显的副作用。
• Substituted isoquinolines as ultra short acting neuromuscular blockers
  申请人：Glaxo Wellcome Inc.

  公开号：US06177445B1

  公开（公告）日：2001-01-23

  Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein q and t are independently from 0 to 4; X1 and X2 are independently halogen; ha and hb are independenity from 0 to 2; Z1 and Z2 are indepentdently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl with the proviso that Z1 and Z2 are not both hydrogen; Y1, Y2, and Y3 and Y4 are independently hydrogen, halogen or C1-3 alkoxy; m and p are independently 1 to 6; n and r are independently 0 to 4; with the proviso the if ha and hb are both 0, then r is 0 and n is 0 to 2; R1 to R14 are independently hydrogen, halogen, C1-3 alkoxy, or R2 and R3 together with the carbon atoms to which they are bonded, R5 and R6 together with the carbon atoms to which they are bonded, R9 and R10 together with the carbon atoms to which they are bonded, R12 and R13 together with the carbon atoms to which they are bonded, may independently form a methylenedioxy or ethylenedioxy moiety contained in five- or six-membered ring; W1 and W2 are carbon; and A is a pharmaceutically acceptable anion.

  本发明涉及公式（I）的超短作用神经肌肉松弛剂，其在紧急插管、常规手术和术后情况下作为骨骼肌松弛剂非常有用，其中q和t独立地为0到4；X1和X2独立地为卤素；ha和hb独立地为0到2；Z1和Z2独立地为氢、C1-6烷基、C2-6烯基或C2-6炔基，但须满足Z1和Z2不同时为氢；Y1、Y2、Y3和Y4独立地为氢、卤素或C1-3烷氧基；m和p独立地为1到6；n和r独立地为0到4；但须满足如果ha和hb都为0，则r为0且n为0到2；R1到R14独立地为氢、卤素、C1-3烷氧基，或者R2和R3与它们所结合的碳原子、R5和R6与它们所结合的碳原子、R9和R10与它们所结合的碳原子、R12和R13与它们所结合的碳原子可以独立地形成包含在五元或六元环中的亚甲二氧基或乙撑二氧基基团；W1和W2为碳；A是一种药学上可接受的阴离子。
• REVERSIBLE NONDEPOLARIZING NEUROMUSCULAR BLOCKADE AGENTS AND METHODS FOR THEIR USE
  申请人：Savarese John J.

  公开号：US20120095041A1

  公开（公告）日：2012-04-19

  The invention provides neuromuscular blockade agents of the non-depolarizing type with few if any circulatory effects. Compounds of the invention include bis(isoquinolylalkanol) diesters of fumaric, maleic, succinic, and acetylenedicarboxylic acids; compositions suitable for parenteral administration of these compounds as a surgical adjunct to anesthesia, and methods of preparation of the compounds. Compounds of the invention can produce neuromuscular blockade of short or intermediate duration, which for various compounds can be reversed by administration of a thiol compound such as L-cysteine, D-cysteine or glutathione. For various compounds of the invention, the neuromuscular blockade effect can be reversed quickly, efficiently, and without notable side-effects.

  本发明提供了一种非去极化型的神经肌肉阻滞剂，其循环效应很少或没有。该发明的化合物包括富马酸、马来酸、琥珀酸和乙炔二羧酸的双(异喹啉基烷醇)二酯；适用于这些化合物的静脉注射制剂作为麻醉手术辅助剂，以及制备这些化合物的方法。该发明的化合物可以产生短期或中等期的神经肌肉阻滞效果，对于各种化合物，可以通过给予巯基化合物如L-半胱氨酸、D-半胱氨酸或谷胱甘肽来逆转。对于该发明的各种化合物，神经肌肉阻滞效果可以快速、有效地逆转，且没有明显的副作用。
• One liquid type epoxy resin composition
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0193068A1

  公开（公告）日：1986-09-03

  @ The present invention provides a one-liquid type epoxy resin composition which is useful especially as a coating material and adhesive for a wide range of applications. The resin composition comprises (1) an epoxy resin (A) containing at least an average of two epoxy groups per molecular unit; and (2) a curing agent (B) consisting essentially of a powdery amine compound (C) having a softening point of 50 to 150°C, the particles of said powdery amine compound being coated with at least one of the following layers: (i) a layer formed by adhesion to the surface of said particles of at least one compound selected from the group consisting of an isocyanate (D), a carboxylic acid (E), a carboxylic acid anhydride (F), an acid halogenated compound (G) and an epoxy compound (H); and (ii) a layer formed by covalent bonding of the powdery amine compound (C) with at least one compound selected from the group consisting of an isocyanate (D), a carboxylic acid (E), a carboxylic acid anhydride (F), an acid halogenated compound (G) and an epoxy compound (H); the softening temperature of said curing agent (B) being 5 to 50°C higher than the softening temperature of said powdery amine compound (C).

  本发明提供了一种单液型环氧树脂组合物，该组合物尤其可用作应用广泛的涂层材料和粘合剂。该树脂组合物包括 (1) 环氧树脂（A），平均每个分子单位至少含有两个环氧基团；以及 (2) 固化剂 (B) 主要由粉末状胺化合物 (C) 组成，其软化点为 50 至 150°C，所述粉末状胺化合物的颗粒上至少涂有以下一层： (i) 至少一种选自异氰酸酯 (D)、羧酸 (E)、羧酸酐 (F)、酸性卤化化合物 (G) 和环氧化合物 (H) 的化合物粘附在所述颗粒表面而形成的层；以及 (ii) 由粉状胺化合物（C）与至少一种选自异氰酸酯（D）、羧酸（E）、羧酸酐 （F）、酸卤化合物（G）和环氧化合物（H）的化合物共价键合而形成的层； 所述固化剂（B）的软化温度比所述粉状胺化合物（C）的软化温度高 5 至 50°C。
• Process for producing chlorophenylhydrazine compounds
  申请人：KONICA CORPORATION

  公开号：EP0208477A1

  公开（公告）日：1987-01-14

  A process for producing a chlorophenylhydrazine compound is disclosed, which comprises chlorinating at least one hydrogen atom on the phenyl nucleus in a beta-imidated phenylhydrazine compound and subsequently hydrolyzing the chlorinated compound. Said chlorophenylhydrazine compound is useful as starting material for the production of herbicide, insecticide and photographic coupler is produced in high yield and low cost.

  本发明公开了一种氯苯肼化合物的生产工艺，该工艺包括对β-亚胺化苯肼化合物中苯基核上的至少一个氢原子进行氯化，然后对氯化化合物进行水解。所述氯苯肼化合物可用作生产除草剂、杀虫剂和感光耦合剂的起始原料，产量高且成本低。