2-Acetamido-3-(o-tolyl)acrylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Acetamido-3-(o-tolyl)acrylic acid
• 英文别名: (E)-2-acetamido-3-(2-methylphenyl)prop-2-enoic acid
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: CHZDNJUDKTYQAS-YRNVUSSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] 6-(2-ALKYL-PHENYL) - PYRIDO[2,3-D] PYRIMIDINES USEFUL AS PROTEINE KINASE INHIBITORS<br/>[FR] 6-(2-ALKYL-PHÉNYL)-PYRIDO[2,3-D]PYRIMIDINES UTILES COMME INHIBITEURS DE LA PROTÉINE KINASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2006032452A1

  公开（公告）日：2006-03-30

  Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式(I)的化合物、它们的药用可接受盐、对映异构体、非对映异构体和外消旋混合物，上述化合物的制备、含有它们的药物及其制造，以及上述化合物在控制或预防诸如癌症等疾病方面的用途。
• 6-(2-ALKYL-PHENYL)-PYRIDO[2,3-D]PYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Honold Konrad

  公开号：US20090247518A1

  公开（公告）日：2009-10-01

  Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式I的化合物及其药学上可接受的盐、对映体、二对映异构体和外消旋体，上述化合物的制备方法、含有它们的药物以及它们的制造，以及上述化合物在控制或预防癌症等疾病中的应用。
• 6-(2-Alkyl-Phenyl)-Pyrido[2,3-D]Pyrimidines useful as Proteine Kinase Inhibitors
  申请人：Honold Konrad

  公开号：US20070259899A1

  公开（公告）日：2007-11-08

  Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式（I）化合物及其药学上可接受的盐、对映体、二对映异构体和外消旋体，上述化合物的制备，含有它们的药物以及其制造，以及上述化合物在控制或预防癌症等疾病方面的用途。
• 6-(2-ALKYL-PHENYL) - PYRIDO[2,3-D] PYRIMIDINES USEFUL AS PROTEINE KINASE INHIBITORS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1794160A1

  公开（公告）日：2007-06-13
• US7550589B2
  申请人：——

  公开号：US7550589B2

  公开（公告）日：2009-06-23