1-(2-hydroxy-3-methoxypropyl)-2-nitrobenzimidazole | 83166-99-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(2-hydroxy-3-methoxypropyl)-2-nitrobenzimidazole
• 英文别名: 1-Methoxy-3-(2-nitrobenzimidazol-1-yl)propan-2-ol
• CAS: 83166-99-8
• 化学式: C₁₁H₁₃N₃O₄
• 分子量: 251.242
• InChiKey: ZIXIBWIEMYNHLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (甲氧基甲基)环氧乙烷 、 2-硝基-1H-苯并咪唑 以45%的产率得到
  参考文献：
  名称：

  GUPTA, R. P.;LARROQUETTE, C. A.;AGRAWAL, K. C., J. MED. CHEM., 1982, 25, N 11, 1342-1346

  摘要：

  DOI：

文献信息

• Potential radiosensitizing agents. 5. 2-Substituted benzimidazole derivatives
  作者：Rajender P. Gupta、Cynthia A. Larroquette、Krishna C. Agrawal

  DOI：10.1021/jm00353a014

  日期：1982.11

  A series of 2-substituted benzimidazoles and their derivatives have been synthesized and tested for their ability to selectively sensitize hypoxic Chinese hamster cells (V-79) toward the lethal effect of ionizing radiation. These compounds were prepared by reacting the 2-substituted benzimidazoles with 1,2-epoxy-3-methoxypropane in the presence of potassium carbonate. Reaction of the 2-nitro and 2-methylfonyl analogue with the epoxide also yielded a cyclized material, which was confirmed to be a benzimidazo[2,1-b]oxazole. In an attempt to increase the electron affinity, 5- or 6-nitro-2-substituted-benzimidazoles were also synthesized and then reacted with the epoxide to yield the corresponding 1-substituted derivatives. The results of the biological tests for the radiosensitizing activity of these agents against Chinese hamster cells (V-79) in culture indicated that the 2-nitro-substituted analogues were the most effective sensitizers in this series.
• GUPTA, R. P.;LARROQUETTE, C. A.;AGRAWAL, K. C., J. MED. CHEM., 1982, 25, N 11, 1342-1346
  作者：GUPTA, R. P.、LARROQUETTE, C. A.、AGRAWAL, K. C.

  DOI：——

  日期：——