3-(2-bromophenyl)-2-(2,6-dimethylphenylamino)-4H-furo[3,2-c]chromen-4-one | 1327337-16-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(2-bromophenyl)-2-(2,6-dimethylphenylamino)-4H-furo[3,2-c]chromen-4-one
• 英文别名: 3-(2-Bromophenyl)-2-(2,6-dimethylanilino)furo[3,2-c]chromen-4-one；3-(2-bromophenyl)-2-(2,6-dimethylanilino)furo[3,2-c]chromen-4-one
• CAS: 1327337-16-5
• 化学式: C₂₅H₁₈BrNO₃
• 分子量: 460.327
• InChiKey: ZNJILENPYDKTKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2-bromophenyl)-2-(2,6-dimethylphenylamino)-4H-furo[3,2-c]chromen-4-one 在 copper(l) iodide 、 potassium carbonate 、 L-脯氨酸 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以86%的产率得到11-(2,6-dimethylphenyl)chromeno[3',4':4,5]furo[2,3-b]indol-6(11H)-one
  参考文献：
  名称：

  I-MCR-Ullmann cascade toward furo[2,3-b]indole scaffold

  摘要：

  An efficient method for the construction of furo[2,3-b]indole derivatives 5 via an isocyanide-based multicomponent reaction (I-MCR) and a copper-catalyzed intramolecular Ullmann reaction sequence was described. This two-step sequence can be performed in a one-pot manner to produce the desired product 5 in moderate to good yield (up to 90%). (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2011.05.101
• 作为产物：
  描述：

  4-羟基香豆素 、 2,6-二甲基苯基异腈 、 邻溴苯甲醛 以 甲苯 为溶剂， 反应 24.0h， 以92%的产率得到3-(2-bromophenyl)-2-(2,6-dimethylphenylamino)-4H-furo[3,2-c]chromen-4-one
  参考文献：
  名称：

  I-MCR-Ullmann cascade toward furo[2,3-b]indole scaffold

  摘要：

  An efficient method for the construction of furo[2,3-b]indole derivatives 5 via an isocyanide-based multicomponent reaction (I-MCR) and a copper-catalyzed intramolecular Ullmann reaction sequence was described. This two-step sequence can be performed in a one-pot manner to produce the desired product 5 in moderate to good yield (up to 90%). (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2011.05.101

文献信息

• I-MCR-Ullmann cascade toward furo[2,3-b]indole scaffold
  作者：Xu Zhu、Xiao-Ping Xu、Chang Sun、Tao Chen、Zhi-Liang Shen、Shun-Jun Ji

  DOI：10.1016/j.tet.2011.05.101

  日期：2011.8

  An efficient method for the construction of furo[2,3-b]indole derivatives 5 via an isocyanide-based multicomponent reaction (I-MCR) and a copper-catalyzed intramolecular Ullmann reaction sequence was described. This two-step sequence can be performed in a one-pot manner to produce the desired product 5 in moderate to good yield (up to 90%). (C) 2011 Published by Elsevier Ltd.