N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide;sulfuric acid | 4420-78-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide;sulfuric acid
• CAS: 4420-78-4
• 化学式: C13H18N2O7S
• 分子量: 346.36
• InChiKey: TXSYIENJFACIJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.91
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  157
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• COMPOSITION COMPRISING MELATONIN, PIPERINE AND VITAMIN D, CONTROLLED-RELEASE FORMULATION AND USE THEREOF FOR THE TREATMENT OF SLEEP DISORDERS
  申请人：Uriach Consumer Healthcare, S.L.

  公开号：EP4019017A1

  公开（公告）日：2022-06-29

  The present invention related to a composition comprising at least melatonin, piperine and vitamin D and a controlled-release formulation thereof for the treatment of sleep disorders. The controlled-release formulation of the present invention comprises a fast release composition to promote a rapid sleep onset, a medium release composition that contributes to a restorative sleep, and a prolonged release composition that provides a good quality sleep during the night.

  本发明涉及一种至少包含褪黑素、胡椒碱和维生素D的组合物及其控释制剂，用于治疗睡眠障碍。本发明的控释制剂包括促进快速入睡的快速释放组合物、有助于恢复睡眠的中等释放组合物以及在夜间提供优质睡眠的长效释放组合物。
• Melatonin monoclonal antibody, detection, methods and uses thereof
  申请人：SALIMETRICS, LLC

  公开号：US10787512B2

  公开（公告）日：2020-09-29

  The invention provides monoclonal antibodies and fragments thereof that specifically bind to melatonin. Also provided are heavy chain variable region (VH) and light chain variable region (VL) sequences of such monoclonal antibodies and fragments thereof. Further provided are melatonin conjugates, and methods and uses, for example, determining, detecting, measuring, screening for, analyzing and monitoring an amount of melatonin in a sample.

  本发明提供了与褪黑激素特异性结合的单克隆抗体及其片段。还提供了此类单克隆抗体及其片段的重链可变区（VH）和轻链可变区（VL）序列。本发明还提供了褪黑素共轭物，以及确定、检测、测量、筛选、分析和监测样品中褪黑素含量的方法和用途。
• Method for the treatment of neurological or neuropsychiatric disorders
  申请人：——

  公开号：US20020068692A1

  公开（公告）日：2002-06-06

  A method for the treatment and/or prophylaxis of a neurological or neuropsychiatric disorder associated with altered dopamine function which comprises subjecting a patient in need thereof to therapy which blocks and/or inhibits melatonin, precursors thereof and/or metabolic products thereof

  一种治疗和/或预防与多巴胺功能改变有关的神经或神经精神疾病的方法，包括让有需要的患者接受阻断和/或抑制褪黑激素、其前体和/或其代谢产物的疗法
• Daily melatonin dosing units
  申请人：Schmid W. Hans

  公开号：US20060035924A1

  公开（公告）日：2006-02-16

  The present invention relates to a disposable container for a medicament or cosmetic agent for topical application, containing a single dose of melatonin or of a melatonin derivative which corresponds to a locally effective dose but which does not cause any systemic effect.

  本发明涉及一种用于外用药物或化妆品的一次性容器，其中含有单剂量的褪黑素或褪黑素衍生物，该剂量相当于局部有效剂量，但不会造成任何全身影响。
• EP0964679A4
  申请人：——

  公开号：EP0964679A4

  公开（公告）日：2002-09-11