4-methyl-1-(ethoxymethoxy)methyl benzene | 93306-62-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-1-(ethoxymethoxy)methyl benzene
• 英文别名: Ethoxymethyl-<4-methyl-benzyl>-ether；Ethoxymethyl-(4-methyl-benzyl)-ether；1-(Ethoxymethoxymethyl)-4-methylbenzene
• CAS: 93306-62-8
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: AJPRBIHHSJAVET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methyl-1-(ethoxymethoxy)methyl benzene 在 四丁基溴化铵 、 1-n-butyl-3-methylimidazolium tetrachloroindate 作用下， 反应 0.07h， 以84%的产率得到4-甲基苄溴
  参考文献：
  名称：

  Microwave-promoted, one-pot conversion of alkoxymethylated protected alcohols into their corresponding nitriles, bromides, and iodides using [bmim][InCl4] as a green catalyst

  摘要：

  The Lewis acid room temperature ionic liquid, [bmim][InCl4], was found to be an efficient and green catalyst for the highly chemoselective and one-pot conversion of MOM- or EOM-ethers into their corresponding nitriles, bromides, and iodides under microwave irradiation. The procedures are simple, rapid, and high yielding. The catalyst exhibited a remarkable reactivity and is reusable. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.056

文献信息

• Microwave-promoted, one-pot conversion of alkoxymethylated protected alcohols into their corresponding nitriles, bromides, and iodides using [bmim][InCl4] as a green catalyst
  作者：Arsalan Mirjafari、Iraj Mohammadpoor-Baltork、Majid Moghadam、Shahram Tangestaninejad、Valiollah Mirkhani、Ahmad Reza Khosropour

  DOI：10.1016/j.tetlet.2010.04.056

  日期：2010.6

  The Lewis acid room temperature ionic liquid, [bmim][InCl4], was found to be an efficient and green catalyst for the highly chemoselective and one-pot conversion of MOM- or EOM-ethers into their corresponding nitriles, bromides, and iodides under microwave irradiation. The procedures are simple, rapid, and high yielding. The catalyst exhibited a remarkable reactivity and is reusable. (C) 2010 Elsevier Ltd. All rights reserved.