methyl 4-[5-(4-chlorophenyl)-3-isoxazolyl]benzoate | 480390-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 4-[5-(4-chlorophenyl)-3-isoxazolyl]benzoate
• 英文别名: methyl 4-[5-(4-chlorophenyl)-1,2-oxazol-3-yl]benzoate
• CAS: 480390-74-7
• 化学式: C₁₇H₁₂ClNO₃
• 分子量: 313.74
• InChiKey: MAPHRYIRGJLHBQ-UHFFFAOYSA-N

物化性质

• 沸点：
  483.7±40.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 4-[5-(4-chlorophenyl)-3-isoxazolyl]benzoate 在 aqueous sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以92%的产率得到4-[5-(4-chlorophenyl)-3-isoxazolyl]benzoic acid
  参考文献：
  名称：

  EP1405636

  摘要：

  公开号：
• 作为产物：
  描述：

  methyl 4-[chloro(hydroxyimino)methyl]benzoate 、 2-氯乙炔基苯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以91%的产率得到methyl 4-[5-(4-chlorophenyl)-3-isoxazolyl]benzoate
  参考文献：
  名称：

  EP1405636

  摘要：

  公开号：

文献信息

• Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
  申请人：——

  公开号：US20020049213A1

  公开（公告）日：2002-04-25

  The invention relates to isoxazole and oxadiazole compounds of Formulae I and II, 1 pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of IL-8 and are thus useful as anti-inflammatory agents for a variety of diseases.

  该发明涉及具有I和II式的异噁唑和氧代噁唑化合物，含有这些化合物的药物组合物，以及它们的生产和使用方法。这些化合物有效地抑制IL-8的作用，因此可用作多种疾病的抗炎药物。
• Function regulator for retinoid relative receptor
  申请人：——

  公开号：US20040157881A1

  公开（公告）日：2004-08-12

  The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulating agent comprising a compound represented by the formula: 1 wherein one of R 1 and R 2 is an optionally substituted monocyclic aromatic hydrocarbon group or an optionally substituted monocyclic aromatic heterocyclic group containing one heteroatom, and the other is a hydrogen atom and the like; B is a 5- or 6-membered heterocycle (except 1,3-azole); A is an optionally substituted aromatic hydrocarbon group or an optionally substituted aromatic heterocyclic group; and R 3 is a hydrogen atom and the like, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of diabetes mellitus, hyperlipidemia, impaired glucose tolerance or the like.

  本发明提供了一种调节视黄醛相关受体（除视黄酸受体外）功能的药剂，其包括以下式子所示的化合物：1其中R1和R2中的一个是可选的取代的单环芳烃基或含有一个杂原子的可选取代的单环芳杂环基，另一个是氢原子等；B是一个5-或6-成员杂环（除了1,3-唑）；A是一个可选取代的芳香烃基或可选取代的芳香杂环基；R3是氢原子等，或其盐，可用作预防或治疗糖尿病、高脂血症、糖耐量受损等的药剂。
• Compounds for Nonsense Suppression, and Methods for Their Use
  申请人：Almstead Neil G.

  公开号：US20090253699A1

  公开（公告）日：2009-10-08

  The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

  本发明涉及使用本发明的化合物或组合物治疗或预防与mRNA中无意义突变相关的疾病的方法、化合物和组合物。更具体地，本发明涉及用于抑制与mRNA中无意义突变相关的早期翻译终止的方法、化合物和组合物。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH
  申请人：Almstead Neil G.

  公开号：US20110046136A1

  公开（公告）日：2011-02-24

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由核酸序列编码的功能性蛋白质，其中包括一个无意义突变。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能性蛋白质的方法，以及利用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH
  申请人：PTC THERAPEUTICS, INC

  公开号：US20160199357A1

  公开（公告）日：2016-07-14

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由包含无意义突变的核酸序列编码的功能蛋白质。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能蛋白质的方法，并使用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。