2-(2-benzoylphenyl)-1H-isoindole-1,3(2H)-dione | 66614-82-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-benzoylphenyl)-1H-isoindole-1,3(2H)-dione
• 英文别名: 2-(2-benzoylphenyl)isoindoline-1,3-dione；2-(2-benzoylphenyl)phthalimide；o-(N-phthalimido)acetophenone；N-(2-benzoyl-phenyl)-phthalimide；N-(2-Benzoyl-phenyl)-phthalimid；N-(o-Benzoylphenyl)phthalimid；N-(2-Benzoylphenyl)phthalimide；2-(2-benzoylphenyl)isoindole-1,3-dione
• CAS: 66614-82-2
• 化学式: C₂₁H₁₃NO₃
• 分子量: 327.339
• InChiKey: QDPCKUWFILIUPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-benzoylphenyl)-1H-isoindole-1,3(2H)-dione 在 盐酸 、 三乙基硅烷 、 sodium tetrahydroborate 、 三氟乙酸 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成 5H-isoindolo[2,1-a]dibenz[c,f]azepin-14(9bH)-one
  参考文献：
  名称：

  Novel Approach to Isoindolo[2,1-a]quinolines

  摘要：

  An N-acyliminium ion approach towards the synthesis of isoindolo [2,1-a]quinolines by an intramolecular process is described.

  DOI：

  10.1080/00397919808004302
• 作为产物：
  描述：

  2-(1,3-dioxoisoindolin-2-yl)benzoyl chloride 在 三氯化铝 、 sodium azide 作用下， 以 水 、 丙酮 、 苯 为溶剂， 反应 0.5h， 生成 2-(2-benzoylphenyl)-1H-isoindole-1,3(2H)-dione
  参考文献：
  名称：

  Fahmy, A. F. M.; Aly, N. F.; Mohamed, M. M., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 308 - 311

  摘要：

  DOI：

文献信息

• Room Temperature Palladium-Catalyzed Decarboxylative Acyl/Aroylation using [Fe(III)(EDTA)(η²-O₂)]³⁻as Oxidant at Biological pH
  作者：Sugandha Sharma、Imran A. Khan、Anil K. Saxena

  DOI：10.1002/adsc.201201085

  日期：2013.3.11

  The purple‐coloured iron peroxo complex [Fe(III)EDTA(η2‐O2)]3− as a novel reagent system for Pd‐catalyzed decarboxylative ortho‐acylation of acetanilides with α‐oxocarboxylic acids at room temperature in aqueous media has been realized. This reaction provides an effective access to ortho‐acylacetanilides under mild conditions.

  紫色着色铁过氧络合物的[Fe（III）EDTA（η 2 -O 2）] 3-作为Pd催化脱羧的新型试剂系统邻在含水介质中在室温下用α-氧代羧酸乙酰苯胺的酰化具有被实现。该反应可在温和条件下有效地获得邻酰基乙酰基苯胺。
• Engels et al., Journal of the Chemical Society, 1959, p. 2694,2699
  作者：Engels et al.

  DOI：——

  日期：——
• Hypolipidemic activity of phthalimide derivatives. 2. N-Phenylphthalimide and derivatives
  作者：James M. Chapman、P. Josee Voorstad、George H. Cocolas、Iris H. Hall

  DOI：10.1021/jm00356a022

  日期：1983.2

  A series of substituted N-phenylphthalimide derivatives was synthesized and examined for their ability to lower serum cholesterol and triglyceride levels in mice at 20 (mg/kg)/day, ip. Of the newly synthesized compounds, the most potent compound, o-(N-phthalimido)acetophenone, lowered serum cholesterol 57% after 16 days and lowered serum triglyceride levels 44% after 14 days. o-(N-Phthalimido)acetophenone was observed to be active in both normogenic (normal blood lipids levels) and hyperlipidemic mice and normogenic rats. In the latter, the reduction of serum lipids was reversible. The mode of this compound appeared to be multiple, including blockage of the de novo synthesis of lipids and acceleration of the excretion of lipids. The lipoprotein fractions of rat blood were reduced significantly in cholesterol, triglyceride, and neutral lipid content after 14 days treatment with o-(N-phthalimido)acetophenone.
• Intramolecular Addition of a Hydroxyl to an N-Acyliminium System. Application to the Synthesis of Isoindolo[2,1-a][3,1]benzoxazine and Isoindolo[1,2-c][2,4]benzoxazepine Derivatives
  作者：Bernard Decroix、Pascal Pigeon、Jana Sikoraiova、Stefan Marchalin

  DOI：10.3987/com-01-s(k)5

  日期：——
• 558. The preparation of some 2-amino- and 2-phthalimido-benzophenones
  作者：M. Lamchen、A. J. Wicken

  DOI：10.1039/jr9590002779

  日期：——