1,1,2-trifluoro-3-(4-fluoro-3-phenoxyphenyl)-1-propene | 312521-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,2-trifluoro-3-(4-fluoro-3-phenoxyphenyl)-1-propene
• 英文别名: 1-fluoro-2-phenoxy-4-(2,3,3-trifluoroprop-2-enyl)benzene
• CAS: 312521-62-3
• 化学式: C₁₅H₁₀F₄O
• 分子量: 282.237
• InChiKey: QTQGFMNOYVUTBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,1,2-trifluoro-3-(4-fluoro-3-phenoxyphenyl)-1-propene 在 sodium bis(2-methoxyethoxy)aluminum dihydride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 以97%的产率得到1,2-Difluoro-3-(4-fluoro-3-phenoxyphen-yl)-1-propene
  参考文献：
  名称：

  Process and intermediate compounds for the preparation of difluorovinylsilane insecticidal and acaricidal agents

  摘要：

  本发明提供了一种改进的过程和中间化合物，用于制备式I的二氟乙烯基硅烷杀虫剂和杀螨剂，其中Ar为苯基，1-或2-萘基或5-或6-成员杂芳环，每个可选地由任意组合的1至3个卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基，C（O）R2或S（O）nR3基取代；R和R1分别是C1-C4烷基或C3-C5环烷基；Ar1是苯氧苯基，苯基，联苯基；苯氧吡啶基，苄基吡啶基，苄基苯基，1-或2-萘基或5-或6-成员杂芳环，每个可选地由任意组合的1至5个卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基或C（O）R4基取代；n是0、1或2的整数；R2和R4各自独立地是C1-C4烷基，苄基或苯基；R3是C114 C4烷基或C1-C4卤代烷基；以及附加到双键的氟原子相对于彼此是反式的。

  公开号：

  US06207846B1
• 作为产物：
  描述：

  溴代三氟代乙烯 、 4-fluoro-3-phenoxybenzyl bromide 在 四(三苯基膦)钯 锌 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以14%的产率得到1,1,2-trifluoro-3-(4-fluoro-3-phenoxyphenyl)-1-propene
  参考文献：
  名称：

  Process and intermediate compounds for the preparation of

  摘要：

  本发明提供了一种改进的过程和中间化合物，用于制备式I的二氟乙烯基硅烷杀虫剂和杀螨剂：其中Ar是苯基，1-或2-萘基或5-或6-成员杂环芳基环，每个可选择地由任意组合的1至3个卤素，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4卤代烷基，C.sub.1-C.sub.4烷氧基，卤代烷氧基，C(O)R.sub.2或S(O).sub.nR.sub.3基取代；R和R.sub.1各自独立地是C.sub.1-C.sub.4烷基或C.sub.3-C.sub.5环烷基；Ar.sub.1是苯氧基苯基，苯基，联苯基，苯氧基吡啶基，苄基吡啶基，苄基苯基，1-或2-萘基或5-或6-成员杂环芳基环，每个可选择地由任意组合的1至5个卤素，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4卤代烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4卤代烷氧基或C(O)R.sub.4基取代；n是0、1或2的整数；R.sub.2和R.sub.4各自独立地是C.sub.1-C.sub.4烷基、苄基或苯基；R.sub.3是C.sub.1-C.sub.4烷基或C.sub.1-C.sub.4卤代烷基；且连接双键的氟原子相对于彼此是反式的。

  公开号：

  US06159956A1

文献信息

• US6159956A
  申请人：——

  公开号：US6159956A

  公开（公告）日：2000-12-12
• US6207846B1
  申请人：——

  公开号：US6207846B1

  公开（公告）日：2001-03-27
• Process and intermediate compounds for the preparation of
  申请人：American Cyanamid Co.

  公开号：US06159956A1

  公开（公告）日：2000-12-12

  The present invention provides an improved process and intermediate compounds for the preparation of difluorovinylsilane insecticide and acaricidal agents of the formula I ##STR1## wherein Ar is phenyl, 1- or 2-napthyl or a 5- or 6-membered heteroaromatic ring, each of which may be optionally substituted by any combination of from one to three halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, haloalkoxy, C(O)R.sub.2 or S(O).sub.n R.sub.3 groups, R and R.sub.1 are each independently C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.5 cycloalkyl; Ar.sub.1 is phenoxyphenyl, phenyl, biphenyl, phenoxypyridyl, benzylpyridyl, benzylphenyl, 1- or 2-napthyl or a 5- or 6-membered heteroaromatic ring, each of which may be optionally substituted by any combination of from one to five halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy or C(O)R.sub.4 groups, n is an integer of 0, 1 or 2; R.sub.2 and R.sub.4 are each independently C.sub.1 -C.sub.4 alkyl, benzyl or phenyl; R.sub.3 is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 haloalkyl; and the fluorine atoms attached to the double bond are trans with respect to each other.

  本发明提供了一种改进的过程和中间化合物，用于制备式I的二氟乙烯基硅烷杀虫剂和杀螨剂：其中Ar是苯基，1-或2-萘基或5-或6-成员杂环芳基环，每个可选择地由任意组合的1至3个卤素，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4卤代烷基，C.sub.1-C.sub.4烷氧基，卤代烷氧基，C(O)R.sub.2或S(O).sub.nR.sub.3基取代；R和R.sub.1各自独立地是C.sub.1-C.sub.4烷基或C.sub.3-C.sub.5环烷基；Ar.sub.1是苯氧基苯基，苯基，联苯基，苯氧基吡啶基，苄基吡啶基，苄基苯基，1-或2-萘基或5-或6-成员杂环芳基环，每个可选择地由任意组合的1至5个卤素，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4卤代烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4卤代烷氧基或C(O)R.sub.4基取代；n是0、1或2的整数；R.sub.2和R.sub.4各自独立地是C.sub.1-C.sub.4烷基、苄基或苯基；R.sub.3是C.sub.1-C.sub.4烷基或C.sub.1-C.sub.4卤代烷基；且连接双键的氟原子相对于彼此是反式的。
• Process and intermediate compounds for the preparation of difluorovinylsilane insecticidal and acaricidal agents
  申请人：American Cyanamid Co.

  公开号：US06207846B1

  公开（公告）日：2001-03-27

  The present invention provides an improved process and intermediate compounds for the preparation of di-fluorovinylsilane insecticidal and acaricidal agents of the formula I wherein Ar is phenyl, 1- or 2-napthyl or a 5- or 6-membered heteroaromatic ring, each of which may be optionally substituted by any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, C(O)R2 or S(O)nR3 groups, R and R1 are each independently C1-C4 alkyl or C3-C5 cycloalkyl; Ar1 is phenoxyphenyl, phenyl, biphenyl; phenoxypyridyl, benzylpyridyl, benzylphenyl, 1- or 2- napthyl or a 5- or 6-membered heteroaromatic ring, each of which may be optionally substituted by any combination of from one to five halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy or C(O)R4 groups, n is an integer of 0, 1 or 2; R2 and R4 are each independently C1-C4alkyl, benzyl or phenyl; R3 is C114 C4alkyl or C1 -C4haloalkyl; and the fluorine atoms attached to the double bond are trans with respect to each other.

  本发明提供了一种改进的过程和中间化合物，用于制备式I的二氟乙烯基硅烷杀虫剂和杀螨剂，其中Ar为苯基，1-或2-萘基或5-或6-成员杂芳环，每个可选地由任意组合的1至3个卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基，C（O）R2或S（O）nR3基取代；R和R1分别是C1-C4烷基或C3-C5环烷基；Ar1是苯氧苯基，苯基，联苯基；苯氧吡啶基，苄基吡啶基，苄基苯基，1-或2-萘基或5-或6-成员杂芳环，每个可选地由任意组合的1至5个卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基或C（O）R4基取代；n是0、1或2的整数；R2和R4各自独立地是C1-C4烷基，苄基或苯基；R3是C114 C4烷基或C1-C4卤代烷基；以及附加到双键的氟原子相对于彼此是反式的。