3,5,3',5'-tetraiodo-thyronine methyl ester; hydrochloride | 86154-70-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,5,3',5'-tetraiodo-thyronine methyl ester; hydrochloride
• 英文别名: 3,5,3',5'-Tetrajod-thyronin-methylester; Hydrochlorid；Methyl 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate;hydrochloride
• CAS: 86154-70-3
• 化学式: C₁₆H₁₃I₄NO₄*ClH
• 分子量: 827.362
• InChiKey: MLBBKTFJGPTWFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  81.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,5,3',5'-tetraiodo-thyronine methyl ester; hydrochloride 、 七氟丁酸酐 以 乙腈 为溶剂， 反应 1.5h， 生成 2,2,3,3,4,4,4-Heptafluoro-butyric acid 4-{4-[2-(2,2,3,3,4,4,4-heptafluoro-butyrylamino)-2-methoxycarbonyl-ethyl]-2,6-diiodo-phenoxy}-2,6-diiodo-phenyl ester
  参考文献：
  名称：

  Attogram-level detection and relative sensitivity of strong electrophores by gas chromatography with electron capture detection

  摘要：

  DOI：

  10.1021/ac00240a029
• 作为产物：
  描述：

  甲醇 、 甲状腺素 在 盐酸 作用下， 反应 1.5h， 生成 3,5,3',5'-tetraiodo-thyronine methyl ester; hydrochloride
  参考文献：
  名称：

  Attogram-level detection and relative sensitivity of strong electrophores by gas chromatography with electron capture detection

  摘要：

  DOI：

  10.1021/ac00240a029

文献信息

• Multilayer analysis element utilizing specific binding reaction
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0066648A1

  公开（公告）日：1982-12-15

  A dry type multilayer analysis element for assaying a concentration of a specific component utilizing a competitive immune reaction comprises a detection element comprising a detection layer which receives a labelled complex formed as a result of the competitive immune reaction or an optically detectable change formed dependant upon an amount of the labelled complex of the specific component and having further provided thereon the detection layer a reaction layer comprising a fibrous porous medium. The multilayer analysis element absorbs an amount of a sample solution necessary for the competitive immune reaction so that the multilayer analysis element has high sensitivity and high reproducibility.

  一种利用竞争性免疫反应测定特定成分浓度的干式多层分析元件包括一个检测元件，该检测元件由一个检测层组成，该检测层接收竞争性免疫反应形成的标记复合物或根据特定成分标记复合物的量形成的可光学检测的变化，检测层上还设有一个由纤维多孔介质组成的反应层。多层分析元件吸收竞争性免疫反应所需的一定量的样品溶液，从而使多层分析元件具有高灵敏度和高再现性。
• Method for quantitative analysis of low molecular weight components contained in protein-containing liquid sample
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0100543A1

  公开（公告）日：1984-02-15

  A method for quantitative analysis of low molecular weight components which are contained in a protein-containing liquid sample originating from body fluids and are capable of binding to said protein, characterized by incorporating into the liquid sample a compound having the formula (I): In which M is hydrogen ion, an alkali metal ion, or ammonium ion; X is a straight or branched alkyl, alkanyl, fluorinated alkyl, or fluorinated alkenyl group containing at least 6 carbon atoms, Y is a divalent organic residue: and p is 0 or 1.

  一种定量分析低分子量组分的方法，这些组分包含在来自体液的含蛋白质液体样品中，并能与所述蛋白质结合，其特征是在液体样品中加入具有式(I)的化合物： 其中 M 是氢离子、碱金属离子或铵离子；X 是直链或支链烷基、烷基、氟化烷基或氟化烯基，至少含有 6 个碳原子；Y 是二价有机残基；p 是 0 或 1。
• Multilayer analytical element for non-isotopic assay
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0119623A2

  公开（公告）日：1984-09-26

  A multilayer analytical element for non-isotopic assay of an analyte contained in an aqueous liquid sample, utilizing a competitive binding reaction to a protein between the analyte and a non-isotopically labeled analyte substance or analogue thereof, which comprises: a light-transmissive water-impermeable support; a sheet provided on the support, which comprises a continuous binder matrix containing the non-isotopically labeled analyte substance or analogue thereof; a porous reaction sheet provided on the binder matrix sheet, which contains a predetermined amount of the protein fixed therein, the protein being specifically bindable to the analyte; and a porous sharing sheet provided on the reaction sheet, in which the substantial separation of the bound non-isotopically labeled complex (B) from the free non-isotopically labeled analyte substance or analogue thereof (F) is accomplished by the presence of said porous sharing sheet. A slide enclosing the multilayer analytical element and a non-isotopic assay employing the multilayer analytical element are also disclosed.

  一种多层分析元件，利用分析物与非同位素标记的分析物或其类似物之间与蛋白质的竞争性结合反应，对水性液体样品中所含的分析物进行非同位素检测，该元件包括： 透光不透水的支架； 在支架上设置的薄片，包括连续的粘合剂基质，其中含有非同位素标记的被分析物质或其类似物； 在粘合剂基质薄片上设置的多孔反应薄片，其中固定有预定量的蛋白质，蛋白质可与分析物特异性结合；以及 反应片上的多孔共享片、 其中，结合的非同位素标记复合物（B）与游离的非同位素标记分析物质或其类似物（F）的实质性分离是通过所述多孔共享片的存在来实现的。 此外，还公开了封装多层分析元件的载玻片和采用多层分析元件的非同位素检测方法。
• Binding assay with amplified read-out and gas-phase detection
  申请人：ALLIED CORPORATION

  公开号：EP0173055A2

  公开（公告）日：1986-03-05

  At the conclusion of a selective binding assay (e.g., immunological or nucleic acid), an enzyme is present in modulated concentration and/or activity to moderate a chemical reaction such as the cleavage of o-nitrophenyl-β-D-galactopyranoside. After a controlled period, the enzymatic product is transferred to the gas phase and concentrated relative to other components in the enzymatic reaction mixture, such as by extraction into ethyl ether, injection into a gas chromatography column and detection by flame ionization or electron capture. Kits for such assays are also disclosed.

  在选择性结合试验（如免疫学或核酸）结束时，酶以调节的浓度和/或活性存在，以缓和化学反应，如邻硝基苯基-β-D-吡喃半乳糖苷的裂解。 经过一段控制时间后，酶产物被转移到气相中，并相对于酶反应混合物中的其他成分浓缩，如通过萃取到乙醚中，注入气相色谱柱，并通过火焰电离或电子捕获进行检测。 还公开了用于此类试验的试剂盒。
• Fluorescent labels and labeled species and their use in analytical elements and determinations
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0195624A2

  公开（公告）日：1986-09-24

  Fluorescent labels comprise a polysaccharide bound to a polymeric particle which contains a fluorescent rare earth chelate. These labels can be attached to any of a variety of physiologically reactive species to provide labeled species which have improved stability in aqueous solutions. The labeled species are particularly useful in specific binding assays to determine an immunologically reactive ligand, e.g. a hapten, in either solution or dry analytical techniques.

  荧光标签由与含有荧光稀土螯合物的聚合物颗粒结合的多糖组成。 这些标签可附着在各种生理活性物质上，以提供在水溶液中稳定性更好的标记物质。 标记物质特别适用于特异性结合测定，以确定溶液或干分析技术中的免疫活性配体（如合体）。