3-aminopropyl dodecanoate | 94205-34-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-aminopropyl dodecanoate
• CAS: 94205-34-2
• 化学式: C₁₅H₃₁NO₂
• 分子量: 257.417
• InChiKey: AGSOXXXISCQKRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-((tert-butoxycarbonyl)amino)propyl dodecanoate 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 以71%的产率得到3-aminopropyl dodecanoate
  参考文献：
  名称：

  Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

  摘要：

  N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 mu M), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.03.065

文献信息

• Method for preserving quaternary ammonium salt
  申请人：——

  公开号：US20030153785A1

  公开（公告）日：2003-08-14

  A method of improving the stability of a quaternary ammonium salt and a method of efficiently preparing the quaternary ammonium salt having improved stability.

  一种提高季铵盐稳定性的方法和一种高效制备稳定性提高的季铵盐的方法。
• PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE AND CONDENSING AGENT COMPRISING QUATERNARY AMMONIUM SALT
  申请人：TOKUYAMA CORPORATION

  公开号：EP1085000A1

  公开（公告）日：2001-03-21

  A process for producing a carboxylic acid derivative characterized by mixing a quaternary ammonium salt having a specific triazine ring in the molecule, a carboxylic acid compound, and a compound having a nucleophilic functional group to conduct the condensation reaction of the carboxylic acid compound with the compound having a nucleophilic functional group; and a condensing agent comprising the quaternary ammonium salt. By the process, the condensation reaction can be conducted under mild conditions and a carboxylic acid derivative, especially an amide or ester compound, can be obtained in high yield.

  一种生产羧酸衍生物的工艺，其特征在于将分子中含有特定三嗪环的季铵盐、羧酸化合物和具有亲核官能团的化合物混合，以进行羧酸化合物与具有亲核官能团的化合物的缩合反应；以及由季铵盐组成的缩合剂。通过该工艺，可在温和条件下进行缩合反应，并以高产率获得羧酸衍生物，特别是酰胺或酯类化合物。
• Method for storing quaternary ammonium salt
  申请人：——

  公开号：US20040147740A1

  公开（公告）日：2004-07-29

  A method of improving the stability of a quaternary ammonium salt and a method of efficiently preparing the quaternary ammonium salt having improved stability.

  一种提高季铵盐稳定性的方法和一种高效制备稳定性得到提高的季铵盐的方法。
• METHOD FOR STORING QUATERNARY AMMONIUM SALT
  申请人：TOKUYAMA CORPORATION

  公开号：EP1178043B1

  公开（公告）日：2005-12-28
• Antithrombotic pharmaceutical preparation containing 2,2'-dithiobis benzamide derivatives and new 2,2'-dithiobis benzamide derivatives
  申请人：KYOWA HAKKO KOGYO CO., LTD

  公开号：EP0006227B1

  公开（公告）日：1984-12-27