N-(cyclopropylmethyl)-N-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine p-toluenesulfonate | 1151663-97-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(cyclopropylmethyl)-N-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine p-toluenesulfonate
• 英文别名: N-(cyclopropylmethyl)-N-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine;4-methylbenzenesulfonic acid
• CAS: 1151663-97-6
• 化学式: C₇H₈O₃S*C₁₃H₁₉N₃
• 分子量: 389.519
• InChiKey: JKJJXHUUYLPEOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.82
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  90.9
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-benzyl-N-(cyclopropylmethyl)-N-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine 、 对甲苯磺酸 在 20 % Pd(OH)2/C 氢气 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以40%的产率得到N-(cyclopropylmethyl)-N-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine p-toluenesulfonate
  参考文献：
  名称：

  EP2216023

  摘要：

  公开号：

文献信息

• CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
  申请人：Matsumoto Takahiro

  公开号：US20100266504A1

  公开（公告）日：2010-10-21

  Provided are a condensed pyridine derivative having a serotonin 5-HT 2C receptor activation action, a prophylactic or therapeutic agent for a lower urinary tract symptom, obesity and/or organ prolapse and the like containing the condensed pyridine derivative, a screening method for a substance that increases leak point pressure upon a rise in the intravesical pressure or a prophylactic or therapeutic drug for stress urinary incontinence, a prophylactic or therapeutic drug for cystoceles or enteroceles, containing a substance that activates serotonin 5-HT 2C receptor, and a method of screening for a therapeutic drug for cystoceles or enteroceles, including increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and measuring a closure response in the urethra, the rectum or the vagina observed at that time. A serotonin 5-HT 2c receptor activator containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.

  提供了一种具有血清素5-HT2C受体激活作用的缩合吡啶衍生物，以及包含该缩合吡啶衍生物的预防或治疗下尿路症状、肥胖和/或器官脱垂等药物，以及增加膀胱内压力时增加泄漏点压力或预防或治疗压力性尿失禁的药物筛选方法，包含激活血清素5-HT2C受体的物质的预防或治疗膀胱脱垂或肠脱垂的药物，以及通过双侧切断动物的会阴神经和耻骨神经后增加膀胱内压力并测量尿道、直肠或阴道在此时观察到的闭合反应的膀胱脱垂或肠脱垂的治疗药物筛选方法。其中包含式的化合物的血清素5-HT2C受体激活剂：式中每个符号如规范中定义的那样，或其盐。
• Condensed pyridine derivate and use thereof
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2789338A2

  公开（公告）日：2014-10-15

  Described is a method of screening for a drug for the prophylaxis or treatment of cystoceles or enteroceles, comprising increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and measuring a closure response in the urethra, the rectum or the vagina observed at that time.

  描述了一种筛选预防或治疗膀胱或肠瘘药物的方法，包括在双侧切断动物的下腹神经和阴部神经后增加膀胱内压，并测量当时观察到的尿道、直肠或阴道的闭合反应。
• EP2216023
  申请人：——

  公开号：——

  公开（公告）日：——