1-(Butylamino)-2-phenoxyethanol | 412959-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(Butylamino)-2-phenoxyethanol
• CAS: 412959-79-6
• 化学式: C₁₂H₁₉NO₂
• mdl: MFCD00449485
• 分子量: 209.288
• InChiKey: OTURUNIUJSKFDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基缩水甘油醚 、 正丁胺 在 Zn(ClO₄)2/Al₂O₃ 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以85%的产率得到1-(Butylamino)-2-phenoxyethanol
  参考文献：
  名称：

  Regioselective ring-opening of epoxides with amines using Zn(ClO4)2–Al2O3 as a heterogeneous and recyclable catalyst

  摘要：

  A simple and efficient method has been developed for the synthesis of P-amino alcohols by regioselective ring-opening of epoxides with amines in the presence of zinc perchlorate-neutral alumina as a heterogeneous recyclable catalyst at room temperature in high yields. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.044

文献信息

• Regioselective ring-opening of epoxides with amines using Zn(ClO4)2–Al2O3 as a heterogeneous and recyclable catalyst
  作者：Muchchintala Maheswara、Kummari Subba Venkata Krishna Rao、Jung Yun Do

  DOI：10.1016/j.tetlet.2008.01.044

  日期：2008.3

  A simple and efficient method has been developed for the synthesis of P-amino alcohols by regioselective ring-opening of epoxides with amines in the presence of zinc perchlorate-neutral alumina as a heterogeneous recyclable catalyst at room temperature in high yields. (c) 2008 Elsevier Ltd. All rights reserved.