4-[(2-hydroxy-3-phenoxypropyl)amino]benzonitrile | 1179978-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[(2-hydroxy-3-phenoxypropyl)amino]benzonitrile
• CAS: 1179978-74-5
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: GGNQKXTYZLZEKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  65.28
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  苯基缩水甘油醚 、 对氨基苯腈 在 magnesium(II) perchlorate 作用下， 反应 7.0h， 以96%的产率得到4-[(2-hydroxy-3-phenoxypropyl)amino]benzonitrile
  参考文献：
  名称：

  Mg(ClO₄)₂, an Efficient Catalyst for Synthesis of β-Amino Alcohols by Ring Opening of Epoxides with Amines under Solvent-Free Conditions

  摘要：

  [image omitted] Commercially available magnesium perchlorate is reported as an extremely efficient catalyst for the ring-opening reaction of epoxide with various primary and secondary amines, especially diphenyl amine, under solvent-free conditions at room temperature.

  DOI：

  10.1080/00397911003629473

文献信息

• Mg(ClO₄)₂, an Efficient Catalyst for Synthesis of β-Amino Alcohols by Ring Opening of Epoxides with Amines under Solvent-Free Conditions
  作者：Abbas Ali Jafari、Moradgholi

  DOI：10.1080/00397911003629473

  日期：2011.1.31

  [image omitted] Commercially available magnesium perchlorate is reported as an extremely efficient catalyst for the ring-opening reaction of epoxide with various primary and secondary amines, especially diphenyl amine, under solvent-free conditions at room temperature.