(+/-)-4-(2,4-dinitrophenyloxy)-1,2-butanediol | 40742-24-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-4-(2,4-dinitrophenyloxy)-1,2-butanediol
• 英文别名: 1,2-dihydroxy-4-(2,4-dinitrophenyloxy)-butane；4-(2,4-Dinitrophenoxy)butane-1,2-diol
• CAS: 40742-24-3
• 化学式: C₁₀H₁₂N₂O₇
• 分子量: 272.214
• InChiKey: OHCOHIIRRMKQNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  141
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (+/-)-4-(2,4-dinitrophenyloxy)-1,2-butanediol 、 月桂酰氯 在 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以54%的产率得到(+/-)-4-(2,4-dinitrophenyloxy)-2-hydroxybut-1-yl dodecanoate
  参考文献：
  名称：

  Universal chromogenic substrates for lipases and esterases

  摘要：

  Chromogenic mono- and diacyl-glycerol analogues were prepared and tested as substrates against lipases and esterases in a microtiter plate setup. Thirty-three enzyme samples were analyzed for activity at 100, 10, and 1 mugmL(-1). The reaction rates observed were visualized by RGB-color coding of activities, and analyzed by cluster analysis. The C8-, C10-, and C12-monoesters of the nitrophenol-derived diol 13 reacted very strongly across all enzyme samples tested, and appear as universal substrates for these enzymes. Such universal chromogenic probes may be used to detect even dilute lipases and esterases in crude cultures. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.07.059
• 作为产物：
  描述：

  (+/-)-1,2-O-isopropylydene-4-(2,4-dinitrophenyloxy)-1,2-butanediol 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以99%的产率得到(+/-)-4-(2,4-dinitrophenyloxy)-1,2-butanediol
  参考文献：
  名称：

  Universal chromogenic substrates for lipases and esterases

  摘要：

  Chromogenic mono- and diacyl-glycerol analogues were prepared and tested as substrates against lipases and esterases in a microtiter plate setup. Thirty-three enzyme samples were analyzed for activity at 100, 10, and 1 mugmL(-1). The reaction rates observed were visualized by RGB-color coding of activities, and analyzed by cluster analysis. The C8-, C10-, and C12-monoesters of the nitrophenol-derived diol 13 reacted very strongly across all enzyme samples tested, and appear as universal substrates for these enzymes. Such universal chromogenic probes may be used to detect even dilute lipases and esterases in crude cultures. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.07.059

文献信息

• US4123614A
  申请人：——

  公开号：US4123614A

  公开（公告）日：1978-10-31
• Universal chromogenic substrates for lipases and esterases
  作者：Johann Grognux、Denis Wahler、Erich Nyfeler、Jean-Louis Reymond

  DOI：10.1016/j.tetasy.2004.07.059

  日期：2004.9

  Chromogenic mono- and diacyl-glycerol analogues were prepared and tested as substrates against lipases and esterases in a microtiter plate setup. Thirty-three enzyme samples were analyzed for activity at 100, 10, and 1 mugmL(-1). The reaction rates observed were visualized by RGB-color coding of activities, and analyzed by cluster analysis. The C8-, C10-, and C12-monoesters of the nitrophenol-derived diol 13 reacted very strongly across all enzyme samples tested, and appear as universal substrates for these enzymes. Such universal chromogenic probes may be used to detect even dilute lipases and esterases in crude cultures. (C) 2004 Elsevier Ltd. All rights reserved.