3-[3-[3-[Bis(3-hydroxypropyl)amino]propoxy]propyl-(3-hydroxypropyl)amino]propan-1-ol | 644968-66-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-[3-[3-[Bis(3-hydroxypropyl)amino]propoxy]propyl-(3-hydroxypropyl)amino]propan-1-ol
• CAS: 644968-66-1
• 化学式: C₁₈H₄₀N₂O₅
• 分子量: 364.526
• InChiKey: ADNUMCCRAVZYBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  96.6
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-[3-[3-[Bis(3-hydroxypropyl)amino]propoxy]propyl-(3-hydroxypropyl)amino]propan-1-ol 在 三溴化磷 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Covalent assembly-disassembly of poly(ether imine) dendritic macromolecular monomers and megamers

  摘要：

  Poly(ether imine) dendritic macromolecules were undertaken to study the reversible dendrimer monomer-megamer assembly-disassembly in aqueous solutions. Synthesis of thiol functionalized poly(ether imine) (PETIM) dendrimers and their covalent aggregation behavior in the aqueous solution of ethanol/water (2:1) is demonstrated. The dendritic megamers were characterized using microscopic techniques. Kinetics of the aggregation behavior was followed using turbidity measurements, light-scattering and atomic force microscopic techniques. Inherent luminescence behavior of PETIM dendrimer monomers was retained in the dendrimer megamers also, which allowed visualization of the megamers through confocal microscopy. Extent of thiol functionalities that remained after the megamer assembly was estimated through Ellman's assay. Subsequent to megamer assembly, disassembly of megamers to dendrimer monomers was conducted, using dithiothreitol reagent. Water-insoluble sudan I dye was encapsulated in dendrimer megamer and subsequent release profile was assessed during the disassembly in aqueous solutions. The studies were conducted using first, second and third generations, representing 4, 8 and 16 sulfhydryl groups at their peripheries of dendrimers, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2014.08.039
• 作为产物：
  描述：

  氰乙基纤维素 在 Raney Co lithium aluminium tetrahydride 、 水 、 氢气 、 乙酰氯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 70.0 ℃ 、4.05 MPa 条件下， 反应 16.5h， 生成 3-[3-[3-[Bis(3-hydroxypropyl)amino]propoxy]propyl-(3-hydroxypropyl)amino]propan-1-ol
  参考文献：
  名称：

  聚（丙醚亚胺）树状聚合物的合成及其细胞毒性的评价。

  摘要：

  在本文中，我们报告了几种聚（丙醚亚胺）树枝状和树枝状聚合物的合成。这些树枝状和树枝状大分子是通过包含醚作为连接剂组分和亚胺作为支化组分而构建的。借助两个交替的迈克尔加成反应和两个交替的还原反应以四步迭代的合成顺序建立树枝状和树枝状大分子的不同合成。合成了多达三代的树枝状分子，并将某些树枝状分子连接到类苯环核上，从而获得了多达两代的树枝状聚合物，其树枝状聚合物在外围含有12个羧酸。发现以醚为核心的发散合成更容易，在每个单独的步骤中，均获得了良好的收率和优异的收率，并且获得了在外围具有多达16个羧酸的三代树枝状大分子。采用的合成顺序使我们可以在其外围安装醇，胺或羧酸。对羧酸封端的树枝状和树枝状大分子的细胞毒性进行了评估，尽管大多数树枝状和树枝状大分子都没有表现出可测量的细胞毒性，甚至高达100微克/毫升，具有苯并类核的第二代树枝状大分子也显示出轻度的毒性。浓度超过30微克/毫升。

  DOI：

  10.1021/jo035072y

文献信息

• In-plane modulated smectic à vs smectic ‘A’ lamellar structures in poly(ethyl or propyl ether imine) dendrimers
  作者：Prabhat Kumar、D.S. Shankar Rao、S. Krishna Prasad、N. Jayaraman

  DOI：10.1016/j.polymer.2016.01.043

  日期：2016.3

  A pair of first and second generation poly(alkyl ether imine) dendrimers is prepared, having covalently attached cholesteryl moieties at their peripheries. The pairs in each generation differ in the alkyl-linker which constitute the dendritic core moieties, even when the number of cholesteryl moieties remains uniform in each pair. The dendrimer pairs are two first and second generation poly(ethyl ether

  制备一对第一和第二代聚（烷基醚亚胺）树状聚合物，它们在其外围具有共价连接的胆固醇基部分。即使当每一对中的胆固醇基部分的数目保持均匀时，每一代中的对在构成树突状核心部分的烷基连接基上也不同。树枝状大分子对是两个第一和第二代聚（乙基亚胺）和聚（丙基）醚亚胺）树状大分子，分别在每对外围用4和8个胆固醇酯改性。树枝状聚合物对表现出不同的热致中间相性质。显微，热和X射线衍射研究表明，第一代乙基，第一代和第二代丙基接头树状聚合物的层状中间相。而第二代乙基接头树状聚合物表现出具有叠加的面内调制的层状结构，其长度对应于矩形柱的宽度。研究了具有不同接头的树枝状聚合物核心部分在修饰中间相性质中的作用。
• Connector type-controlled mesophase structures in poly(propyl ether imine) dendritic liquid crystals of identical dendrimer generations
  作者：Prabhat Kumar、D. S. Shankar Rao、S. Krishna Prasad、Narayanaswamy Jayaraman

  DOI：10.1002/pola.28709

  日期：2017.11.15

  Poly(propyl ether imine) (PETIM) dendrimers of one to three generations are used as dendritic cores to identify the influence of varying connector types that connect the dendritic core with peripheral mesogens on the emerging liquid crystalline (LC) properties. The LC properties vary in these dendritic liquid crystals, even when the dendrimer generations and thus the number of peripheral mesogenic

  1-3代的聚（丙醚亚胺）（PETIM）树状聚合物被用作树状核，以识别将树状核与外围液晶元相连的不同连接器类型对新兴液晶（LC）性能的影响。在这些树状液晶中，即使当树状聚合物的世代以及因此外围介晶部分的数目保持相同时，LC性质也变化。本文研究了PETIM第一至第三代树状大分子，随琥珀酸酯，邻苯二甲酸酯和琥珀酰胺变化的酯和酰胺连接体。通过上述连接器将胆固醇基部分安装在外围以诱导介晶性质。这些改性的树枝状液晶在大多数酯和酰胺连接基衍生物中显示出层状的中间相结构，而第三代邻苯二甲酸酯树状大分子则倾向于矩形柱状中间相结构。从层状到矩形柱状结构的转变是由于在一个特定的树枝状聚合物世代内，在琥珀酸酯或琥珀酰胺或邻苯二甲酸酯之间变化的连接体的简单变化而没有改变下面的树枝状聚合物核或介晶部分的数量。研究表明，在化学成分基本相同的树枝状液晶中，连接液晶元和树枝状聚合物核的连接体类型的变化足以改变中间相结构。©2017
• Increased Efficacies of an Individual Catalytic Site in Clustered Multivalent Dendritic Catalysts
  作者：Govindasamy Jayamurugan、Narayanaswamy Jayaraman

  DOI：10.1002/adsc.200900377

  日期：2009.10

  as many as 11 catalysts within three generations were synthesized. The CC bond-forming reactions, namely, the Heck and the Suzuki coupling reactions, were then selected to study the catalytic efficiencies of the series of partially and fully phosphine-metal complex functionalized dendrimers. The efficacies of the formation of cinnamate and biphenyl, catalyzed by the dendritic catalysts, were compared

  迄今为止，在有关树状聚合物介导的催化作用的研究报告中，主要研究了催化单元的效率，并比较了各个世代。为了确定单个催化单元相对于给定世代中存在的此类单元的数量的功效，在一代内制备了一系列催化剂。选择与膦金属配合物结合的树枝状聚合物进行研究，并在三代内合成了多达11种催化剂。然后选择CC键形成反应，即Heck和Suzuki偶联反应，以研究一系列部分和完全膦-金属配合物官能化的树枝状聚合物的催化效率。比较了树状催化剂催化肉桂酸酯和联苯形成的效率。比较分析表明，当以多个数量存在时（即在多价树状体系中），单个催化位点的催化活性要比在同一世代（即在一价树状系统中）中的单个单元有效得多。这项研究确定了在树状聚合物世代之内和之间以及树状聚合物世代中催化部分多价呈递的有益作用。
• Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery
  作者：Subheet Jain、Amanpreet Kaur、Richa Puri、Puneet Utreja、Anubhuti Jain、Mahesh Bhide、Rakesh Ratnam、Vinay Singh、A.S. Patil、N. Jayaraman、Gaurav Kaushik、Subodh Yadav、K.L. Khanduja

  DOI：10.1016/j.ejmech.2010.08.006

  日期：2010.11

  In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery. (C) 2010 Elsevier Masson SAS. All rights reserved.
• Synthesis and catalytic activities of PdII–phosphine complexes modified poly(ether imine) dendrimers
  作者：Thatavarathy Rama Krishna、Narayanaswamy Jayaraman

  DOI：10.1016/j.tet.2004.08.067

  日期：2004.11

  In this paper, we report synthesis of new alkyldiphenyl phosphine ligand modified poly(ether imine) dendrimers up to the third generation. The phosphinated dendrimers were obtained by functional group transformations of the alcohols present at the periphery of the dendrimers to chloride, followed by phosphination using LiPPh2. The modification at the peripheries of the dendrimers was performed successfully to obtain up to 16 alkyl diphenylphosphines in the case of a third generation dendrimer, in good yields for each individual step. After phosphination, dendritic ligands were complexed with Pd(COD)Cl-2 to give dendritic phosphine-Pd-11 complexes. Both the ligands and the metal complexes were characterized by spectroscopic and spectrometric techniques including high-resolution mass spectral analysis for the lower generations. Evaluation of the catalytic efficacies of the dendrimer-Pd-11 metal complexes in mediating a prototypical C-C bond forming reaction, namely the Heck reaction, was performed using various olefin substrates. While the substrate conversion lowered with catalyst in the order from monomer to third generation dendrimer, the second and third generation dendrimers themselves were found to exhibit significantly better catalytic activities than the monomer and the first generation dendrimer. (C) 2004 Elsevier Ltd. All rights reserved.