7,8-dimethoxynaphthalen-1-ol | 97944-71-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7,8-dimethoxynaphthalen-1-ol
• CAS: 97944-71-3
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: YJSUSJFZDKEOAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7,8-dimethoxynaphthalen-1-ol 在 4-二甲氨基吡啶 三乙基硅烷 、 ammonium cerium(IV) nitrate 、 三氟化硼乙醚 、 硝酸 、 三溴化硼 、 三乙胺 、 三氟乙酸 、 silver(l) oxide 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 51.08h， 生成 5-epi-arizonin C1
  参考文献：
  名称：

  Synthe1sis of 5-epi-arizonin B1 and 5-epi-arizonin C1

  摘要：

  The first synthesis of 5-epi-arizonin B1 (19) and 5-epi-arizonin C1 (18) is described in which the key step involves rearrangement of a furo[3,2-b]naphtho[2,1-d]furan (16) to a furo[3,2-b]naphtho[2,3-b]naphtho[2,3-d]pyran (17). Regioselective synthesis of naphthoquinone (15) was crucial to this synthetic strategy.

  DOI：

  10.1016/s0040-4039(00)73868-8
• 作为产物：
  描述：

  5-chloro-7,8-dimethoxy-1-tetralone 在 palladium on activated charcoal 萘 、 氢气 、 sodium acetate 作用下， 生成 7,8-dimethoxynaphthalen-1-ol
  参考文献：
  名称：

  Carvalho, Christopher F.; Russo, Albert V.; Sargent, Melvyn V., Australian Journal of Chemistry, 1985, vol. 38, # 5, p. 777 - 792

  摘要：

  DOI：

文献信息

• Application of directed metallation in synthesis. Part 3: Studies in the synthesis of (±)-semivioxanthin and its analogues
  作者：Sukanta Kamila、Chandrani Mukherjee、Sasanka S Mondal、Asish De

  DOI：10.1016/s0040-4020(02)01599-5

  日期：2003.2

  The synthesis of several analogues of (+/-)-semivioxanthin including five thiophene analogues, using directed metalation are reported. The strategy consisted of the synthesis of functionalized naphthalene or benzo[b]thiophene as building blocks followed by annelation of the pyrone. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Giles, Robin G. F.; Hughes, Andrew B.; Sargent, Melvyn V., Journal of the Chemical Society. Perkin transactions I, 1991, # 6, p. 1581 - 1587
  作者：Giles, Robin G. F.、Hughes, Andrew B.、Sargent, Melvyn V.

  DOI：——

  日期：——
• Brimble, Margaret A.; Phythian, Sara J.; Prabaharan, Hishani, Journal of the Chemical Society. Perkin transactions I, 1995, # 22, p. 2855 - 2860
  作者：Brimble, Margaret A.、Phythian, Sara J.、Prabaharan, Hishani

  DOI：——

  日期：——
• Carvalho, Christopher F.; Russo, Albert V.; Sargent, Melvyn V., Australian Journal of Chemistry, 1985, vol. 38, # 5, p. 777 - 792
  作者：Carvalho, Christopher F.、Russo, Albert V.、Sargent, Melvyn V.

  DOI：——

  日期：——
• Synthe1sis of 5-epi-arizonin B1 and 5-epi-arizonin C1
  作者：Margaret A. Brimble、Sara J. Phythian

  DOI：10.1016/s0040-4039(00)73868-8

  日期：1993.9

  The first synthesis of 5-epi-arizonin B1 (19) and 5-epi-arizonin C1 (18) is described in which the key step involves rearrangement of a furo[3,2-b]naphtho[2,1-d]furan (16) to a furo[3,2-b]naphtho[2,3-b]naphtho[2,3-d]pyran (17). Regioselective synthesis of naphthoquinone (15) was crucial to this synthetic strategy.